Enhanced cell survival of pH-sensitive bioenergetic nucleotide nanoparticles in energy/oxygen-depleted cells and their intranasal delivery for reduced brain infarction

Improved Brain Delivery of Pueraria Flavones Via Intranasal Administration Of Borneol-Modified Solid Lipid Nanoparticles

“…Intranasal delivery allows noninvasive and direct delivery of drug to the brain and offers enhanced patient compliance for future clinical applications. Also, this nose-to-brain route bypasses the BBB and may avoid drug elimination by the liver and gastrointestinal tract and filtration through the kidney [47]. Intranasal administration has the superiority of rapid absorption into blood and brain over oral administration, and has similar bioavailability compared with intravenous administration which could play a quick emergency role; thus it may become a promising administration route for brain disease treatment.…”

pH-Responsive Multifunctional Theranostic Rapamycin-Loaded Nanoparticles for Imaging and Treatment of Acute Ischemic Stroke

“…Choi et al demonstrated that pH-sensitive bioenergetic nucleotide (NT) nanoparticles showed higher delivery efficiency than free NT, faster release of NT under acidic conditions, and greater resistance to hypothermia, serum deprivation, and hypoxia environments. Notably, the nanoparticles improved neurological function and decreased infarct volume in transient middle cerebral artery occlusion (tMCAO) models (ischemia for 90 min) . In two recent studies, pH-triggered nanomedicines were given simultaneously with reperfusion 2 h after ischemia and 2 h after reperfusion (ischemia for 45min), and the protective effect of these smart NDDS against I/R injury was demonstrated. , Thus, selective delivery of promising neuroprotective drugs to ischemic tissue is feasible through pH-responsive smart nanosystems, where pH-targeted delivery is expected to enrich drugs at the site of injury and reduce the risk of untargeted side effects.…”