Enhanced CCL26 production by IL-4 through IFN-γ-induced upregulation of type 1 IL-4 receptor in keratinocytes

Nishi, Natsuko; Yamamoto, Shuichi; Wei-lin, OU; Muro, Eriko; Inada, Yukiko; Hamasaki, Yuhei

doi:10.1016/j.bbrc.2008.08.136

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…These results suggest that dermal fibroblasts in lesional skin, stimulated with IL-4 expressed by tumor cells, contribute to the elevation of eotaxin-3 and eotaxin-1 in patients with CTCL. Immunohistochemistry showed that epidermal KCs and endothelial cells as well as dermal fibroblasts expressed eotaxin-3, consistent with previous reports (Hoeck and Woisetschläger, 2001;Kleinhans et al, 2003;Nishi et al, 2008). However, we could not confirm eotaxin-1 expression in the skin by immunohistochemistry, probably because of sensitivity issues.…”

Section: Discussionsupporting

confidence: 81%

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Eotaxins and CCR3 Interaction Regulates the Th2 Environment of Cutaneous T-Cell Lymphoma

Miyagaki

Sugaya

Fujita

et al. 2010

Journal of Investigative Dermatology

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CC chemokine receptor 3 (CCR3), the sole receptor for eotaxins, is expressed on eosinophils and T helper type 2 (Th2) cells. In Hodgkin's disease, eotaxin-1 secreted by fibroblasts collects Th2 cells and eosinophils within the tissue. Similarly, many Th2 cells infiltrate the lesional skin of cutaneous T-cell lymphoma (CTCL). In this study, we investigated the role of eotaxins in the development of the Th2 environment of CTCL. We revealed that fibroblasts from lesional skin of CTCL expressed higher amounts of eotaxin-3 messenger RNA (mRNA) compared with those from normal skin. Lesional skin of CTCL at advanced stages contained significantly higher levels of eotaxin-3 and CCR3 mRNA, compared with early stages of CTCL. IL-4 mRNA was expressed in some cases at advanced stages. Immunohistochemistry revealed that keratinocytes, endothelial cells, and dermal fibroblasts in lesional skin of CTCL showed a stronger expression of eotaxin-3 than did normal skin. CCR3(+) lymphocytes and IL-4 expression were observed in some cases of advanced CTCL. Furthermore, both serum eotaxin-3 and eotaxin-1 levels of CTCL patients at advanced stages were significantly higher than those of healthy individuals. The concentrations of these chemokines correlated with serum soluble IL-2 receptor levels. These results suggest that interaction of eotaxins and CCR3 regulates the Th2-dominant tumor environment, which is closely related to the development of CTCL.

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Section: Discussionsupporting

confidence: 81%

“…Eotaxin-3 is reported to be expressed by epidermal KCs (Nishi et al, 2008), dermal fibroblasts (Hoeck and Woisetschläger, 2001), and endothelial cells (Shinkai et al, 1999). Eotaxin-1 is expressed by dermal fibroblasts (Miyamasu et al, 1999), endothelial cells (Rothenberg et al, 1995), and dermal dendritic cells (Beaulieu et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Eotaxins and CCR3 Interaction Regulates the Th2 Environment of Cutaneous T-Cell Lymphoma

Miyagaki

Sugaya

Fujita

et al. 2010

Journal of Investigative Dermatology

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“…Normal human epidermal keratinocytes treated with IL-4 show increased expression of CCL26 (eotaxin-3), a key chemokine for eosinophil recruitment [95]. Dermal fibroblasts isolated from patients with acute AD skin lesions were far more responsive to IL-4 in their ability to express CCL11 (eotaxin-1), another critical cytokine for eosinophil recruitment [96].…”

Section: Th2 Cytokinesmentioning

confidence: 99%

Th2 Cytokines and Atopic Dermatitis

Brandt

Sivaprasad

2011

J Clin Cell Immunol

533

433

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Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in prevalence around the world. Intensive research is ongoing to understand the mechanisms involved in the development of AD and offer new treatment options for patients suffering from AD. In this review, we highlight the importance of allergic Th2 responses in the development of the disease and summarize relevant literature, including genetic studies, studies of human skin and mechanistic studies on keratinocytes and mouse models of AD. We discuss the importance of the skin barrier and review recent findings on the pro-Th2 cytokines TSLP, IL-25, and IL-33, notably their ability to polarize dendritic cells and promote Th2 responses. After a brief update on the contribution of different T-cell subsets to AD, we focus on Th2 cells and the respective contributions of each of the Th2 cytokines (IL-4, IL-13, IL-5, IL-31, and IL-10) to AD. We conclude with a brief discussion of the current gaps in our knowledge and technical limitations.

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“…They also produce chemokines, including MCP-1/CCL2, MIP-1a/CCL3, MIP-1b/CCL4, RANTES/CCL5, TARC/ CCL17, MIP-3a/CCL20, MDC/CCL22, eotaxin-3/CCL26, CTACK/ CCL27, Gro-a/CXCL1, Mig/CXCL9, IP-10/CXCL10, I-TAC/CXCL11, CXCL16, and fractalkine/CX3CL1 [75,[92][93][94][95][96][97][98][99][100]. These keratinocytederived cytokines and chemokines regulate the inflammatory and immune responses of resident Langerhans cells, dermal fibroblasts, and endothelial cells, as well as infiltrating cells.…”

Section: Growth Factors and Cytokines Produced By Epidermal Keratinocmentioning

confidence: 99%

Regulation of epidermal keratinocytes by growth factors

Shirakata

2010

Journal of Dermatological Science

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Enhanced CCL26 production by IL-4 through IFN-γ-induced upregulation of type 1 IL-4 receptor in keratinocytes

Cited by 10 publications

References 31 publications

Eotaxins and CCR3 Interaction Regulates the Th2 Environment of Cutaneous T-Cell Lymphoma

Eotaxins and CCR3 Interaction Regulates the Th2 Environment of Cutaneous T-Cell Lymphoma

Th2 Cytokines and Atopic Dermatitis

Regulation of epidermal keratinocytes by growth factors

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