Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

Zhang, Kai; Meng, Xiangdan; Yang, Zhou; Dong, Haifeng; Zhang, Xueji

doi:10.1016/j.biomaterials.2020.120278

Cited by 161 publications

(105 citation statements)

References 35 publications

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“…Bio-distribution, which is the pattern of MOFs accumulation in different organs in the body, is also crucial for the overall assessment of the delivery system. MOFs usually tend to accumulate in liver 94,95 and kidney 96 , as they are the main organs responsible for NPs clearance. Few have reported high accumulations of MOFs in lungs 97 and spleen 98 .…”

Section: In-vivomentioning

confidence: 99%

Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

2021

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Section: In-vivomentioning

confidence: 99%

Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

2021

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“…This significantly enhances the penetration depth of the nanoparticles within the tumor and offers a novel approach for the design and development of hypoxia‐responsive nanoplatforms for diagnosis and treatment. [ 162 ]…”

Section: Stimulus‐responsive Nanocarrier Delivery Systemsmentioning

confidence: 99%

Recent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy

Cheng

et al. 2021

Advanced Science

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Gene therapy provides a promising strategy for curing monogenetic disorders and complex diseases. However, there are challenges associated with the use of viral delivery vectors. The advent of nanomedicine represents a quantum leap in the application of gene therapy. Recent advances in stimulus-responsive nonviral nanocarriers indicate that they are efficient delivery systems for loading and unloading of therapeutic nucleic acids. Some nanocarriers are responsive to cues derived from the internal environment, such as changes in pH, redox potential, enzyme activity, reactive oxygen species, adenosine triphosphate, and hypoxia. Others are responsive to external stimulations, including temperature gradients, light irradiation, ultrasonic energy, and magnetic field. Multiple stimuli-responsive strategies have also been investigated recently for experimental gene therapy.

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“…[ 4 ] For example, as explained in reported literature, CuS nanoparticles (NPs) have been developed for lymph node metastasis, [ 5 ] carbon dots have been utilized for gastric cancer therapy, [ 6 ] and metal–organic frameworks (MOF) have been applied for controlled drug delivery. [ 7 ] Due to the sensitive response activity, some new therapeutic modalities based on nanomaterials have been developed, such as photothermal therapy (PTT), [ 8 ] photodynamic therapy (PDT), [ 9 ] sonodynamic therapy (SDT), [ 10 ] starvation therapy (ST), [ 11 ] and so on. These strategies achieve therapeutic effects by amplifying intracellular oxidative stress under the stimulation of light, ultrasound (US), and others.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Jiang

et al. 2021

Adv Funct Materials

264

158

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Triggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non-exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H 2 O 2 ) into the lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor-specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H 2 O 2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo-, ultrasound-, magnetic-, and other stimuli-response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti-cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial-based chemodynamic cancer therapy. In this review, the various nanomaterials-based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better-quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications.

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Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

Cited by 161 publications

References 35 publications

Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

Recent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

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