Enhanced bone formation in electrospun poly(l-lactic-co-glycolic acid)–tussah silk fibroin ultrafine nanofiber scaffolds incorporated with graphene oxide

Shao, Weili; He, Jianxin; Feng, Suying; Wang, Qin; Chen, Li; Cui, Shizhong; Ding, Bin

doi:10.1016/j.msec.2016.01.078

Cited by 106 publications

(96 citation statements)

References 56 publications

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“…The incorporation of cell‐recognition domains such as RGD tripeptides onto biomaterials have been carried out to enhance cell‐scaffold interactions . ASF contains inherent RGD sequences, which may function as a biological recognition signal and promote cell adhesion . Indeed, previous studies have demonstrated that wild SF containing inherent RGD supported better adhesion and proliferation of various cells than BSF .…”

Section: Results and Dicsussionmentioning

confidence: 99%

“…Antheraea pernyi silk is one of the most familiar species among wild non‐mulberry silks. Antheraea pernyi silk fibroin (ASF) contains inherent arginyl‐glycyl‐aspartic (RGD) tripeptide sequences . These RGD sequences are known to be the receptors of cell integrins and may function as a biological recognition signal and promote cell adhesion .…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and characterization of electrospun PCL/Antheraea pernyisilk fibroin nanofibrous scaffolds

Zhang

et al. 2016

Polym Eng Sci

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To engineer tissue restoration, it is necessary to provide a bioactive, mechanically robust scaffold. Electrospun poly(ε‐caprolactone) (PCL) nanofiber is a promising biomaterial candidate with excellent mechanical properties, but PCL scaffolds are inert and lack natural cell recognition sites. To overcome this problem we investigated the incorporation of Antheraea pernyi silk fibroin (ASF) containing inherent RGD tripeptides with PCL in electrospinning process. The mixing ratios showed remarkable impact on the properties of hybrid nanofibers. Increasing PCL content significantly enhanced the mechanical properties of nanofibers. In particular, the mechanical properties were remarkably enhanced when PCL content increased from 50 wt% to 70 wt%. Moreover, the biological assays based on endothelial cells showed promoted cell viability when ASF content reached to 30 wt%. The data demonstrated that the nanofiber containing 70% of PCL and 30% of ASF achieved the most balanced performances for integrating the mechanical properties of PCL and the bioactivity of ASF. Furthermore, biomimetic alignment of 70PCL/30ASF nanofibers was achieved, which could support PC12 neuron‐like cell growth and guide neurite outgrowth, providing a potentially useful option for the engineering of oriented tissues. The results show that the PCL/ASF hybrid nanofibers can be considered as a promising candidate for tissue engineering scaffolds. POLYM. ENG. SCI., 57:206–213, 2017. © 2016 Society of Plastics Engineers

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Section: Results and Dicsussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of electrospun PCL/Antheraea pernyisilk fibroin nanofibrous scaffolds

Zhang

et al. 2016

Polym Eng Sci

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“…It is generally regarded that materials with a higher modulus drive osteogenesis; second, similar in the case for graphene, the exceptional noncovalent binding abilities of GO with biomolecules enable it to accelerate the differentiation of hMSCs into osteogenic cells by acting as a pre‐concentration platform for osteogenic inducers; last, the abundant hydroxyl and carboxyl groups on GO could upregulate osteogenic expression and enhance osteogenesis . For these reasons, GO has also been used simultaneously in conjunction with more than one type of polymers to improve the mechanical performance and biological activities (i.e., cell adhesion, proliferation, and differentiation ability) of polymers …”

Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

131

106

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Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

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“…A C C E P T E D M A N U S C R I P T 20 nHAp/CNT [67], polymeric nanofibers/nHAp [68] and polymeric nanofibers/carbon nanomaterials [69,70]. However, in all of these published papers, the researchers only explored either nHAp alone or its combination with carbon nanomaterials isolated and/or inside polymeric ultrathin fibers, not outside and aligned as demonstrated here using a 3D scaffold.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

On the design and properties of scaffolds based on vertically aligned carbon nanotubes transferred onto electrospun poly (lactic acid) fibers

et al. 2017

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Enhanced bone formation in electrospun poly(l-lactic-co-glycolic acid)–tussah silk fibroin ultrafine nanofiber scaffolds incorporated with graphene oxide

Cited by 106 publications

References 56 publications

Fabrication and characterization of electrospun PCL/Antheraea pernyisilk fibroin nanofibrous scaffolds

Fabrication and characterization of electrospun PCL/Antheraea pernyisilk fibroin nanofibrous scaffolds

Bone Tissue Engineering via Carbon‐Based Nanomaterials

On the design and properties of scaffolds based on vertically aligned carbon nanotubes transferred onto electrospun poly (lactic acid) fibers

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