Enhanced biosensing strategies using electrogenerated chemiluminescence: recent progress and future prospects

Husain, Rashaad A.; Barman, Snigdha Roy; Chatterjee, Subhodeep; Khan, Imran; Lin, Zong‐Hong

doi:10.1039/c9tb02578b

Cited by 28 publications

(19 citation statements)

References 155 publications

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“…Electrochemiluminescence or electrogenerated chemi‐luminescence (ECL) is a type of luminescence that occurs at the electrolyte/electrode interface. Electrochemical reactions lead in fine to the generation of the excited state of a luminophore, which emits light upon relaxation [93–95] . It differs from chemiluminescence and photoluminescence, since it is not a bulk process and does not require a light source.…”

Section: (Electro)chemiluminescent Dynamic Systemsmentioning

confidence: 99%

“…It differs from chemiluminescence and photoluminescence, since it is not a bulk process and does not require a light source. Commonly, ECL reactions can occur via an annihilation or coreactant mechanism [94–96] by using different kinds of luminophores, typically ruthenium, osmium and iridium complexes, organic molecules or even quantum dots and nanoparticles [97,98] . This light emitting phenomenon has been extensively used for different analytical applications, attracting wide interest in immunoassays, DNA probe assays and biosensors [96–98] .…”

Section: (Electro)chemiluminescent Dynamic Systemsmentioning

confidence: 99%

“…In this section we summarize the recent findings on the design and applications of different dynamic ECL and chemiluminescent systems. For a more detailed molecular description of the ECL mechanisms the reader is invited to consult more specialized publications [94–98] …”

Section: (Electro)chemiluminescent Dynamic Systemsmentioning

confidence: 99%

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Electrochemistry‐Based Light‐Emitting Mobile Systems

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Light‐emitting mobile systems are presented as an important concept for direct visualization and tracking of active objects. Motion or light emission can be achieved by different electrochemical mechanisms. Various devices, that generate light by fluorescence, (electro)chemiluminescence or via light emitting diodes are shown to be an interesting alternative for the detection or release of target molecules, providing straightforward optical imaging. This review summarizes and discusses the recent advances with respect to the design and the potential applications of such original systems.

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Section: (Electro)chemiluminescent Dynamic Systemsmentioning

confidence: 99%

Section: (Electro)chemiluminescent Dynamic Systemsmentioning

confidence: 99%

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Electrochemistry‐Based Light‐Emitting Mobile Systems

et al. 2020

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“…Electrogenerated chemiluminescence (electrochemiluminescence, ECL) is a kind of luminescence that occurs at or near the surface of an electrode as a result of electrochemical and chemiluminescence reactions. − ECL is superior to photoluminescence in many respects, as it has an extremely low background, high sensitivity, and temporal and spatial control of the reaction, along with requiring instruments that are inexpensive. The ECL method has received considerable attention in the clinical diagnosis, pharmaceutical analysis, and so on. − …”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Aggregation-Induced Enhanced Electrochemiluminescence of Cyanophenyl-Functionalized Tetraphenylethene and Its Application in Biothiols Analysis

et al. 2022

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Exploring new electrochemiluminescence (ECL) luminophores with high ECL efficiency and good stability in aqueous solution is in great demand for biological sensing. In this work, highly efficient aggregation-induced enhanced ECL of cyanophenyl-functionalized tetraphenylethene (tetra[4-(4cyanophenyl)phenyl]ethene, TCPPE) and its application in biothiols analysis were reported. TCPPE contains four 4cyanophenyl groups covalently attached to the tetraphenylethene (TPE) core, generating a nonplanar three-dimensional twisted conformation structure. TCPPE nanoparticles (NPs) with an average size of 15.84 nm were prepared by a precipitation method. High ECL efficiency (593%, CdS as standard) and stable ECL emission (over one month) were obtained for TCPPE NPs in aqueous solution. The unique properties of TCPPE NPs could be ascribed to the efficient suppression of nonradiative transition, the decrease of the energy gap, and the increase of anionic radical stability, which were proved by theoretical calculation and electrochemical and fluorescence methods. Contrasting aggregation-induced ECL chromic emission was first observed for TCPPE NPs. As a proof-of-methodology, an ECL method was developed for three biothiol assays with detection limits of 6, 7, and 300 nM for cysteine, homocysteine, and glutathione, respectively. This work demonstrates that TCPPE NPs are promising ECL luminophores, and the incorporation of appropriate substituents into luminophores can improve ECL efficiency and radical stability.

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“…Several high-quality reviews have provided detailed summaries of the principles and characteristics of the ECL systems [ 14 , 15 , 16 , 17 ]. However, this study focuses on the most recent developments in ECL systems in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Electrochemiluminescence Systems for the Detection of Biomarkers: Strategical and Technological Advances

2022

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Electrochemiluminescence (ECL)-based sensing systems rely on light emissions from luminophores, which are generated by high-energy electron transfer reactions between electrogenerated species on an electrode. ECL systems have been widely used in the detection and monitoring of diverse, disease-related biomarkers due to their high selectivity and fast response times, as well as their spatial and temporal control of luminance, high controllability, and a wide detection range. This review focuses on the recent strategic and technological advances in ECL-based biomarker detection systems. We introduce several sensing systems for medical applications that are classified according to the reactions that drive ECL signal emissions. We also provide recent examples of sensing strategies and technologies based on factors that enhance sensitivity and multiplexing abilities as well as simplify sensing procedures. This review also discusses the potential strategies and technologies for the development of ECL systems with an enhanced detection ability.

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Enhanced biosensing strategies using electrogenerated chemiluminescence: recent progress and future prospects

Abstract: An overview of enhancement strategies for highly sensitive ECL-based sensing of bioanalytes enabling early detection of cancer.

Cited by 28 publications

References 155 publications

Electrochemistry‐Based Light‐Emitting Mobile Systems

Electrochemistry‐Based Light‐Emitting Mobile Systems

Highly Efficient Aggregation-Induced Enhanced Electrochemiluminescence of Cyanophenyl-Functionalized Tetraphenylethene and Its Application in Biothiols Analysis

Electrochemiluminescence Systems for the Detection of Biomarkers: Strategical and Technological Advances

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