Enhanced Biological Activity of a Novel Preparation of Lavandula angustifolia Essential Oil

Abstract

Lavandula angustifolia, one of the most popular medicinal plants, is the source of a bioactive essential oil characterized by a wide spectrum of biological activity, e.g., antiseptic, analgesic, and anticancer effects. In dermatology, the oil helps to relieve skin inflammation and exhibit wound healing potential. However, the mechanism of action of the lavender oil depends on its composition, which in turn is dependent on the origin and growing conditions. Our study aimed to compare the composition and proregenerative properties of the commercially-available narrow-leaved lavender oil produced in Provence, France, with the oil obtained from the narrow-leaved lavender cultivated locally in Poland. GC/MS analysis showed that self-manufactured essential oil had lower linalool content than commercial oil (23.2 vs. 40.2%), comparable linalyl acetate content (40.6 vs. 44%), while the proportion of lavandulyl acetate was significantly higher (23.2 vs. 5.5%). To determine the influence of lavender oil on the production of proinflammatory cytokines and proregenerative growth factors, gene expression of the selected signaling molecules by HaCaT cells was investigated using real-time PCR. Results showed a concentration-dependent effect of lavender oils on the production of IL-6, IL-8, and VEGF by the keratinocyte cell line. Finally, the potential of the lavender oil to increase the production of VEGF, the most important angiogenic factor, with the in-house preparation performing significantly better in the in vitro cell models was identified.

Exploitation of Marginal Hilly Land in Tuscany through the Cultivation of Lavandula angustifolia Mill.: Characterization of Its Essential Oil and Antibacterial Activity

“…The cited standards confirmed that low levels of camphor and eucalyptol are important in lavender essential oil to differentiate it from lavandin oil. Previous works showed a broad spectrum of the biological activities of this EO, which is used for its sedative, anti-inflammatory, antioxidant, antimicrobial, and antifungal properties, in addition to its use as an insecticide and larvicides, and as an anticancer remedy and food additive [ 6 , 7 , 8 ].…”

Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey

“…The cytotoxicity (IC50) of lavender oil was reported to be 0.28 µg/mL on HEL 12469 human embryo lung cells by Puškárová et al [5]. In another study, Miastkowska et al compared commercial and harvested Lavender essential oils and reported 0.20 v/v and 0.36 v/v for the HaCaT cell line, respectively [15]. In addition, Cardia et al reported that lavender essential oil showed low cytotoxicity on mice leukocytes obtained from the peritoneal cavity, with cell viability greater than 75% up to a concentration of 10 µg/mL [16].…”

Physicochemical Characterization and Prospecting Biological Activity of Some Authentic Transylvanian Essential Oils: Lavender, Sage and Basil

“…Kozics et al [ 71 ] determined a value of IC50 of 0.043% on the human cell line HaCaT (normal keratinocytes). The HaCaT line was used by Miastkowska et al [ 72 ] too, observing that in the case of commercial L. angustifolia EO the value of IC50 was lower (0.20%) than that of the in-house one (0.36%). In another study conducted by Niksic et al [ 73 ], a significant antiproliferative activity of L. angustifolia EO on three cancer cell lines, MOLT-4 (acute lymphoblastic leukemia), MCF-7 (mammary adenocarcinoma) and NCI-H460 (pulmonary carcinoma), was reported.…”