Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey

Abstract

The essential oil obtained from Lavandula angustifolia Mill. (Lavander) has many pharmacological effects, including antioxidant, antifungal, antibacterial and carminative effects. Lavandula angustifolia essential oil (LEO) contains monoterpene compounds, mainly linalool and linalyl acetate and various phenolic acids such as caffeic acid, vanillic acid, ferulic acid and chlorogenic acid. The hydrodistillation of the aerial parts of L. angustifolia produced a pale yellow oil. Gas chromatography-Gas chromatography/Massspectrometry (GC-GC/MS) results showed that LEO contains monoterpene alcohols that primarily include linalool (35.91%), 4-Terpineol (6.10%), α-Terpineol (4.49%) and lavandulol (2.49%). As a result of the cytotoxicity analysis of LEO, the IC50 value was found to be 0.372 mg/mL. LEO was found to be non-mutagenic against the bacterial test strain Salmonella typhimurium TA 98 with S9 fraction while the highest concentration (9.58 mg/mL) was found to be either mutagenic or cytotoxic against TA 98 without S9 fraction. The essential oil's antioxidant capacity was found 6.522±0.069 mg/mL while the total phenolic content was 1.22±0.04 mg GAE/g extract (Gallic acid equivalent/g extract). Anti-inflammatory activity of LEO was 1.238± 0.026 mg/mL while that of indomethacine was 0.022±0.003 mg/mL. In conclusion, when the results are evaluated in terms of in vitro biological activities, LEO can be considered as a potential herbal product with active compounds that should be examined in future studies.

Recent Advances in Chemistry and Antioxidant/Anticancer Biology of Monoterpene and Meroterpenoid Natural Product

“…Linalyl acetate ( 3b , Figure 3 ) has been well documented to have favorable bioactivities. Anticancer properties have been associated with essential oils from Lavandula angustifolia, Lavandula officinalis, Lavandula latifolia , and bergamot [ 40 , 41 , 42 , 43 , 44 ], all of which contain linalyl acetate in concentrations as high as 44%. A study conducted on the lavender essential oils from Lavandula angustifolia demonstrated an IC 50 values of 0.36% ( v / v ) against HaCaT cell line in an MTT assay [ 43 ].…”

Essential Oil of Lavandula officinalis: Chemical Composition and Antibacterial Activities

“…Thus, more investigations would be suitable for wide lavender screening in all regions of Morocco. Omurtag Özgen et al [32], who examined the chemical composition of Lavandula angustifolia EO from Konya, Turkey, also yielded a different result as they found 28 compounds with a predominance of linalool (35.91%), 4-terpineol (6.10%), alpha-terpineol (4.49%) and lavandulol (2.49%) [28]. (4.4%) [27].…”

Lavender and Geranium Essential Oil-Loaded Nanogels with Promising Repellent and Antibacterial Effects

“…Te EO was found to exhibit insecticidal activity and increase the percent repellency against insects [18,19]. Additionally, lavender essential oil has been shown to have antioxidant, antimicrobial, and antifungal properties [20,21]. Besides, geranium EO has been studied about various insects; e.g., it showed a repellent efect against adult fies, specifcally Musca domestica and Lucilia cuprina.…”