Essential Oil of Lavandula officinalis: Chemical Composition and Antibacterial Activities

Abstract

The purpose of this study was to determine the chemical composition of the essential oil of Lavandula officinalis from Morocco using the GC-MS technique and assess the antibacterial effects against seven pathogenic bacteria strains isolated from the food origins of Salmonella infantis, Salmonella kentucky, Salmonella newport, three serotypes of Escherichia coli (O114H8K11, O127K88ac, O127H40K11) and Klebsiella. Tests of sensitivity were carried out on a solid surface using the Disc Diffusion Method. Results showed that E. coli and S.newport were sensitive to Lavandula officinalis essential oil. Minimum inhibitory concentrations (MIC) were determined using the method of agar dilution. The antibacterial results showed that four strains (three serotypes of E. coli, and S. newport) were remarkedly sensitive to Lavandula officinalis essential oil, giving MIC values of 88.7 µg/mL and 177.5 µg/mL. The molecular docking of the main oil products with the E. coli target protein 1VLY, showed that eucalyptol and linalyl acetate bind efficiently with the active site of the target protein. In particular, eucalyptol showed a higher activity than gentamicin used as positive control with a binding energy of −5.72 kcal/mol and −5.55 kcal/mol, respectively.

Antibacterial Activity of Zinc Oxide Nanoparticles Loaded with Essential Oils

“…The thyme essential oil was used as an antiparasitic or to treat minor wounds from ancient times due to its strong antimicrobial properties [21,22]. Lavender [23,24], grapefruit [25,26], bergamot [27,28], cinnamon [29,30], and rosemary [31,32] essential oils have strong antimicrobial activity and therefore are good candidates for innovative antibacterial and antifungal therapies and materials. Nevertheless, the essential oils must be loaded or encapsulated in a matrix, be it organic or inorganic, to ensure a longer release profile, and a sustained antimicrobial activity [33,34].…”

Disclosing the Functional Potency of Three Oxygenated Monoterpenes in Combating Microbial Pathogenesis: From Targeting Virulence Factors to Chicken Meat Preservation

“…Their (ΔG) were estimated to be −6.7 Kcal/mol, −6.6 Kcal/mol, and −6.5 Kcal/mol, respectively ( Table 1 ). Another study indicated that eucalyptol binds efficiently with the active site of the E. coli protein, and it showed a higher activity than gentamicin, with a binding energy of −5.72 kcal/mol and −5.55 kcal/mol [ 63 ].…”

Alzheimer's disease: In silico study of rosemary diterpenes activities

“…Table 1 shows that, in general, carnosic acid and related abietane-type dipertenes extracted from rosemary showed good results/compliance with Lipinski's Rule of Five ( Lipinski et al, 1997 ) (Molecular Weight < 500 Da, # of hydrogen bond donors: Donor HB < 5, # of hydrogen bond acceptors: Acceptor HB < 10, and predicted octanol–water partition coefficient: QPlogPo/w < 5), without any observed violations ( Diass et al, 2023 , Boumezzourh et al, 2023 , Dash et al, 2015 , Khan et al, 2009 , Fajriyah et al, 2023 , Faris et al, 2023 , Zhang and Wilkinson, 2007 , Merzouki et al, 2023 ). Similarly, Table 2 shows that, in general, all compounds exhibit ADME/T properties/pharmacokinetic descriptor values falling within the range of recommended values (values in parentheses at the bottom of the Table 2 ), with no observable violations in terms of drug characteristics.…”