Enhanced bioactivity of electrospun PCL and PLLA scaffolds blended with amino-phosphazene

Sedláková, Veronika; Voráč, Zbyněk; Jaroš, Josef; Bačovská, Radka; Kloučková, Michaela; Svoboda, Michal; Streit, Libor; Dumková, Jana; Vašíčková, Kateřina; Alberti, Milan; Hampl, Aleš

doi:10.1016/j.matlet.2018.06.023

Cited by 4 publications

(2 citation statements)

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“…The availability of a wide range of organic substituents on the -P=N-skeleton also allows the achievement of different 3D architectures in supramolecular arrangements, from electrospun scaffolds [ 36 ] to micelles and polymersomes [ 37 ], when amphiphilic moieties are bonded to the P atoms or through noncovalent interactions ( Figure 2 ) [ 38 , 39 , 40 ].…”

Section: Synthesis and Characterizationsmentioning

confidence: 99%

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Cyclo- and Polyphosphazenes for Biomedical Applications

et al. 2022

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Cyclic and polyphosphazenes are extremely interesting and versatile substrates characterized by the presence of -P=N- repeating units. The chlorine atoms on the P atoms in the starting materials can be easily substituted with a variety of organic substituents, thus giving rise to a huge number of new materials for industrial applications. Their properties can be designed considering the number of repetitive units and the nature of the substituent groups, opening up to a number of peculiar properties, including the ability to give rise to supramolecular arrangements. We focused our attention on the extensive scientific literature concerning their biomedical applications: as antimicrobial agents in drug delivery, as immunoadjuvants in tissue engineering, in innovative anticancer therapies, and treatments for cardiovascular diseases. The promising perspectives for their biomedical use rise from the opportunity to combine the benefits of the inorganic backbone and the wide variety of organic side groups that can lead to the formation of nanoparticles, polymersomes, or scaffolds for cell proliferation. In this review, some aspects of the preparation of phosphazene-based systems and their characterization, together with some of the most relevant chemical strategies to obtain biomaterials, have been described.

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Section: Synthesis and Characterizationsmentioning

confidence: 99%

“…Electrospinning methodology has been reported to prepare nanofibers, membranes, and scaffolds in view of different applications [ 36 , 174 ]. A core sheath nanofiber membrane with poly[bis(p-methylphenoxy)phosphazene] and polyacrylonitrile has been prepared and studied for enzyme (lipase) immobilization [ 175 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%