Enhanced bioactivity, biocompatibility and mechanical behavior of strontium substituted bioactive glasses

Arepalli, Sampath Kumar; Tripathi, Himanshu; Hira, Sumit Kumar; Manna, Partha Pratim; Pyare, Ram; Singh, Swapnil

doi:10.1016/j.msec.2016.06.070

Cited by 68 publications

(25 citation statements)

References 53 publications

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“…In spite of Sr incorporation in the bone regenerative biomaterials, such as synthetic bone grafts, might be an effective way to supply therapeutic Sr 2+ ions to the bone defect sites in osteoporotic patients, an excessive osteoclast inhibition might reduce the long‐term bone regeneration as the remodeling process might also be inhibited. Even though the effect of strontium on the osteoblastic activity is still controversial, some authors have recently shown high bioactivity of Sr‐delivering glasses in antiosteoporotic applications …”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

et al. 2017

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In most minimally-invasive procedures used to address severe pain arising from compression fractures of the vertebral bodies, such as percutaneous vertebroplasty (PVP), a poly(methyl methacrylate) (PMMA) bone cement is used. Shortcomings of this type of cement, such as high exotherm temperature and lack of bioactivity, are well known. We prepared different formulations of a composite bone cement, whose solid constituents consisted of PMMA beads and particles of a bioactive glass (BG), where 0-20%(w/w) of the calcium component was substituted by strontium. The difference between the formulations was in the relative amounts of the solid phase constituents and in the Sr-content of BG. We determined the influence of the mixture of solid phase constituents of the cement formulation on a collection of properties, such as maximum exotherm temperature (T ), setting time (t ), and injectability (I). The selection of the PMMA beads was crucial to obtain cement composite formulations capable to be efficiently injected. Results allowed to select nine solid phase mixtures to be further tested. Then, we determined the influence of the composition of these composite bone cements on T , t , I, and cell proliferation. The results showed that the performance of various of the selected composite cements was better than that of PMMA cement reference, with lower T , lower t , and higher I. We found that incorporation of Sr-substituted BGs into these materials bestows bioactivity properties associated with the role of Sr in bone formation, leading to some composite cement formulations that may be suitable for use in PVP. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1245-1257, 2018.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

et al. 2017

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“…To enhance its biological activity, we added strontium to harness its therapeutic properties [ 9 , 10 ]. Although strontium's mechanism of action remains unknown, strontium-containing inorganic bone substitutes increase bone formation and osteointegration in vivo [ [14] , [15] , [16] , [17] , [18] , [19] , [20] ], and modulate the activity of osteoprogenitors, osteoblasts, and osteoclasts, and macrophage phenotype in vitro [ 11 , 12 , [53] , [54] , [55] , [56] ]. We have recently shown using a whole-genome microarray analysis that strontium incorporation in BG45S5 triggered significant changes in the global gene expression patterns of hMSCs and resulted in important changes in their metabolism and membrane composition [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Following reports demonstrating the efficacy of the anti-osteoporosis drug strontium ranelate (SrRan) [ 9 , 10 ], strontium has been incorporated into BG for bone repair, as BG's amorphous nature allows it to deliver strontium at a sustained rate. In in vitro studies, strontium-substituted BGs increased the anabolic and anti-catabolic activity of osteoblasts and osteoclasts, respectively [ [11] , [12] , [13] ], and strontium-substituted materials showed enhanced bone formation and osteointegration in vivo [ [14] , [15] , [16] , [17] , [18] , [19] , [20] ].…”

Section: Introductionmentioning

confidence: 99%

Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

et al. 2019

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The efficient healing of critical-sized bone defects using synthetic biomaterial-based strategies is promising but remains challenging as it requires the development of biomaterials that combine a 3D porous architecture and a robust biological activity. Bioactive glasses (BGs) are attractive candidates as they stimulate a biological response that favors osteogenesis and vascularization, but amorphous 3D porous BGs are difficult to produce because conventional compositions crystallize during processing. Here, we rationally designed a porous, strontium-releasing, bioactive glass-based scaffold (pSrBG) whose composition was tailored to deliver strontium and whose properties were optimized to retain an amorphous phase, induce tissue infiltration and encourage bone formation. The hypothesis was that it would allow the repair of a critical-sized defect in an ovine model with newly-formed bone exhibiting physiological matrix composition and structural architecture. Histological and histomorphometric analyses combined with indentation testing showed pSrBG encouraged near perfect bone-to-material contact and the formation of well-organized lamellar bone. Analysis of bone quality by a combination of Raman spectral imaging, small-angle X-ray scattering, X-ray fluorescence and focused ion beam-scanning electron microscopy demonstrated that the repaired tissue was akin to that of normal, healthy bone, and incorporated small amounts of strontium in the newly formed bone mineral. These data show the potential of pSrBG to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in large animal models.

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“…The idea of incorporating therapeutically active ions such as strontium and/or aluminum can contribute to a material with additional beneficial effects by providing tissue regeneration capabilities, enhanced bioactivity, and extended working range . Strontium‐containing bioactive glasses have already been recognized to affect bone growth in appropriate quantities . Strontium itself has been used for osteoporosis prevention as a ranelate form (Protelos ® ) .…”

Section: Introductionmentioning

confidence: 99%

“…9,10 Strontium-containing bioactive glasses have already been recognized to affect bone growth in appropriate quantities. [11][12][13][14] Strontium itself has been used for osteoporosis prevention as a ranelate form (Protelos ® ). 15 The strontium addition in bioactive glasses combines the known regenerative properties of bioactive glasses with anabolic and anti-catabolic effects of strontium ions.…”

Section: Introductionmentioning

confidence: 99%

Structural and thermal behavior of 45S5 Bioglass^®‐based compositions containing alumina and strontium

et al. 2020

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The present research exposes the influence of 2 mol% of Al2O3 and 2 mol% SrO in 45S5 Bioglass®‐based compositions. Four compositions were produced to elucidate the difference in how both oxides influence structure and thermal behavior separately and their synergy when together. Thermal properties, crystallization tendency, and sintering behavior was evaluated by differential scanning calorimetry, hot stage microscopy, and dilatometry. Changes of medium‐range structures were characterized by Qn distribution of Raman spectroscopy and evaluation of 31P, 27Al, 23Na, and 29Si environment obtained by magic angle spinning nuclear magnetic resonance. Despite Qn distribution was predominantly Q2 in all samples, the composition criteria used enabled improved processing and stabilibity characteristics. The addition of Al2O3 and SrO promoted larger sinterability parameter (Sc) which indicates better sintering behavior, the glass stability against crystallization doubled (KH) compared to 45S5 and the processing window enlarged from 106 to 171.

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Enhanced bioactivity, biocompatibility and mechanical behavior of strontium substituted bioactive glasses

Cited by 68 publications

References 53 publications

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

Structural and thermal behavior of 45S5 Bioglass^®‐based compositions containing alumina and strontium

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Enhanced bioactivity, biocompatibility and mechanical behavior of strontium substituted bioactive glasses

Cited by 68 publications

References 53 publications

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

Structural and thermal behavior of 45S5 Bioglass®‐based compositions containing alumina and strontium

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Structural and thermal behavior of 45S5 Bioglass^®‐based compositions containing alumina and strontium