Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

Abstract

In most minimally-invasive procedures used to address severe pain arising from compression fractures of the vertebral bodies, such as percutaneous vertebroplasty (PVP), a poly(methyl methacrylate) (PMMA) bone cement is used. Shortcomings of this type of cement, such as high exotherm temperature and lack of bioactivity, are well known. We prepared different formulations of a composite bone cement, whose solid constituents consisted of PMMA beads and particles of a bioactive glass (BG), where 0-20%(w/w) of the calcium component was substituted by strontium. The difference between the formulations was in the relative amounts of the solid phase constituents and in the Sr-content of BG. We determined the influence of the mixture of solid phase constituents of the cement formulation on a collection of properties, such as maximum exotherm temperature (T ), setting time (t ), and injectability (I). The selection of the PMMA beads was crucial to obtain cement composite formulations capable to be efficiently injected. Results allowed to select nine solid phase mixtures to be further tested. Then, we determined the influence of the composition of these composite bone cements on T , t , I, and cell proliferation. The results showed that the performance of various of the selected composite cements was better than that of PMMA cement reference, with lower T , lower t , and higher I. We found that incorporation of Sr-substituted BGs into these materials bestows bioactivity properties associated with the role of Sr in bone formation, leading to some composite cement formulations that may be suitable for use in PVP. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1245-1257, 2018.

Fabrication and Characterizations of Metallic Mg Containing PMMA-Based Partially Degradable Composite Bone Cements

“…Among the PMCs, samples prepared with ''small'' Mg particles showed the best cell adhesion and spreading. The adhesion and spreading of osteoblasts on 0.2-Mg-L, 0.2-Mg-M, 0.2-Mg-S, 0.4-Mg-S and 0.2-ZK61 are all better than those on the PMMA, indicating that the addition of Mg particles in a proper manner could promote the surface bioactivity of polymeric materials, which is consistent with the results reported for PCL/Mg hybrid bone substitute [15] and PLGA/Mg alloy composite [16], as well as PMMA/Sr-BG (bioactive glass) [31] and PMMA/quaternized chitosan [33] composite bone cement.…”

“…Previously, several studies on modified PMMA bone cement by incorporating bioactive or biodegradable additives (such as bioactive glass, hydroxyapatite, chitosan and MgO) in order to enhance its osseointegrative properties have demonstrated promising results [27,28,[31][32][33]. Here, a new composite bone cement combining biodegradable Mg with PMMA was developed and this type of cement, to our knowledge, has not been reported before.…”

Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement

“…One approach has been to add a bioactive agent. Peri-cement bone formation and/or in vitro osteoblastic responses have been improved with bioactive glass [51][52][53][54][55][56], hydroxyapatite [57], or other calcium-containing molecules [58][59][60][61][62][63][64]. These studies adopted the strategy of literally adding bioactivity to bone cement materials via additives, but this approach does not fundamentally improve material biocompatibility.…”

Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering

“…More recently, Goñi et al (2018) prepared different composite bone cements comprising PMMA beads and particles of gel-derived SiO 2 -CaO–P 2 O 5 BGs with 0-20 wt% of CaO substituted with SrO (Mendez et al, 2004). The difference between the cementitious materials was in the Sr content of BG and relative amounts of the solid phase.…”