Enhanced bioactive and osteogenic activities of titanium by modification with phytic acid and calcium hydroxide

Liu, Kun; Zhang, Hao; Lu, Mengmeng; Liu, Lin; Yan, Yanzhe; Chu, Zhuangzhuang; Ge, Yuran; Wang, Tao; Tang, Chunbo

doi:10.1016/j.apsusc.2019.01.219

Cited by 27 publications

(18 citation statements)

References 60 publications

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“…Moreover, PT40 with higher Ta content showed higher cell proliferation than PT20. The attachment and proliferation of cells intensively pertain to the surface characteristics of the implant such as chemical composition, roughness, hydrophilicity and surface energy as well as proteins adsorptions [ 41 ]. Therefore, compared with PT20 and PEKK, the improvement of cell adhesion and proliferation on PT40 was because of more Ta particles distributed on its surface, which had improved surface performances that remarkably promoted cell responses.…”

Section: Discussionmentioning

confidence: 99%

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

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Polyetherketoneketone (PEKK) exhibits admirable biocompatibility and mechanical performances but bioinert while tantalum (Ta) possesses excellent osteogenesis and osseointegration but high elastic modulus and density, and processing is too difficult and expensive. In the present study, combining of the advantages of both PEKK and Ta, implantable composites of PEKK/Ta were fabricated by blending PEKK with Ta microparticles of 20 v% (PT20) and 40 v% (PT40) content. In comparison with PT20 and PEKK, the surface hydrophilicity, surface energy, roughness and proteins adsorption as well as mechanical performances of PT40 significantly increased because of the higher Ta particles content in PEKK. Furthermore, PT40 exhibited the mechanical performances (e.g., compressive strength and modulus of elasticity) close to the cortical bone of human. Compared with PT20 and PEKK, PT40 with higher Ta content remarkably enhanced the responses (including adhesion, proliferation and osteogenic differentiation) of MC3T3-E1 cells in vitro . Moreover, PT40 markedly improved bone formation as well as osseointegration in vivo . In short, incorporation of Ta microparticles into PEKK created implantable composites with improved surface performances, which played key roles in stimulating cell responses/bone formation as well as promoting osseointegration. PT40 might have great potential for bear-loading bone substitute.

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Section: Discussionmentioning

confidence: 99%

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

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“…The formation of calcium hydroxide on the titanium surface is also beneficial because of their antibacterial and osseointegration properties [ 33 , 34 ]. The same increase in the biocompatibility could have also been achieved with the production of other calcium-decorated coatings [ 35 ].…”

Section: Introductionmentioning

confidence: 93%

Composite and Surface Functionalization of Ultrafine-Grained Ti23Zr25Nb Alloy for Medical Applications

et al. 2020

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In this study, the ultrafine-grained Ti23Zr25Nb-based composites with 45S5 Bioglass and Ag, Cu, or Zn additions were produced by application of the mechanical alloying technique. Additionally, the base Ti23Zr25Nb alloy was electrochemically modified in the two stages of processing: electrochemical etching in the solution of H3PO4 and HF followed by electrochemical deposition in Ca(NO3)2, (NH4)2HPO4, and HCl. The in vitro cytocompatibility studies were also done with comparison to the commercially pure titanium. The established cell lines of Normal Human Osteoblasts (NHost, CC-2538) and Human Periodontal Ligament Fibroblasts (HPdLF, CC-7049) were used. The culture was conducted among the tested materials. Ultrafine-grained titanium-based composites modified with 45S5 Bioglass and Ag, Cu, or Zn metals have higher biocompatibility than the reference material in the form of a microcrystalline Ti. Proliferation activity was at a stable level with contact with studied materials. In vitro evaluation research showed that the ultrafine-grained Ti23Zr25Nb-based composites with 45S5 Bioglass and Ag, Cu, or Zn additions, with a Young modulus below 50 GPa, can be further used in the biomedical field.

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“…Due to the chemical structure and properties of IP6, it is thought that IP6 can serve as a bridge between the titanium implant surfaces and calcium ions. This was the basis of the study conducted by Liu et al in 2019, where calcium was successfully bound to implant surfaces via hydrothermal treatment with IP6 and this resulted in a continuous release of calcium over time. The research also reported the super-hydrophilicity of these modified surfaces, with increased cell adhesion and proliferation, and up-regulation of osteogenic-related genes (Liu et al, 2019).…”

Section: Implantologymentioning

confidence: 99%

Phytic Acid: Properties and Potential Applications in Dentistry

Nassar

Maki

et al. 2021

Front. Mater.

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Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density provides IP6 with an immense chelating ability and valuable antioxidant properties. IP6 is also simple and cost-effective to produce. These features have attracted researchers and entrepreneurs to further study IP6 for a wide variety of applications in areas such as pharmaceutical, food and chemical industries, medicine, pharmacy, nutrition, and dentistry. The interest in IP6 in the dental field unfolded many decades ago following identification of a cariostatic ability and a positive impact on reducing enamel dissolution. Subsequently, IP6’s anti-plaque, anti-calculus and cement-forming properties have been investigated. Despite encouraging findings, there was a phase of decreased attention to IP6 which slowed down research progress. However, the potential use of IP6 has recently been revisited through several publications that provided deeper understanding into its mechanisms of action in the aforementioned applications. Studies have also explored new applications in endodontics, adhesive, preventive and regenerative dentistry, and IP6’s role in improving the characteristics and performance of dental materials. Evidence of the merits of IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights of future use of IP6 in the fields of orthodontics, implant and pediatric dentistry.

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Enhanced bioactive and osteogenic activities of titanium by modification with phytic acid and calcium hydroxide

Cited by 27 publications

References 60 publications

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Composite and Surface Functionalization of Ultrafine-Grained Ti23Zr25Nb Alloy for Medical Applications

Phytic Acid: Properties and Potential Applications in Dentistry

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