Enhanced Bactericidal Activity against Escherichia coli in Calves Fed Morinda citrifolia (Noni) Puree

Schäfer, Martin; Sharp, P.; Brooks, V.J.; Xu, Junhua; Cai, Jin; Keuler, N.S.; Peek, SF; Godbee, R.G.; Schultz, Ronald D.; Darien, B. J.

doi:10.1111/j.1939-1676.2008.0044.x

Cited by 21 publications

(19 citation statements)

References 9 publications

(10 reference statements)

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“…In earlier findings, Brooks et al (2009) reported that supplementation of juice from M. citrifolia enhanced the activation of CD4+ and CD8+ T cells in neonatal calves. Bactericidal effect of noni was evaluated via an ex vivo whole blood bactericidal assay by Schäfer et al (2008). Result showed that noni fed group showed significantly more killing power at day 14 when compared to control calves.…”

Section: Growth Production and Imunomodulatory Properties In Livestockmentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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KEYWORDS Morinda citrifolia Livestock Poultry Growth Production Immunomodulatory Properties ABSTRACTMorinda citrifolia L. is commonly known as Noni and has been found to have wide range of medicinal properties. It is usually found in the coastal region in many countries including Andaman and Nicobar Islands and belongs to the family Rubiaceae. This small evergreen tree is widely grown and well adapted to the tropics and can grow in fertile, acidic, alkaline and saline affected soils. It tolerates high soil salinity and brackish water stagnation. All the components of this plant have high demand in case of alternative medicines and herbal medicines. Due to its high demand and as a source of revenue generation the detail study on its nutritional benefits and therapeutic values are essential for its commercial exploitation. More than 200 nutraceutical compounds have been identified from the plant. Morinda citrifolia is reported to have broad spectrum biological activities such as antimicrobial, immunomodualtory, antioxidant wound healing etc. Apart from the in-vitro scientific validation of the activities and in-vivo trial in some lab animal model, the plant has been used for livestock and poultry health and production. A lot of reviews have been written on the different uses of Noni, however, scientific review on the use of this plant on the growth, production, immunomodulator and other pharmacological activities of M. citrifolia in livestock and poultry has not been compiled. Therefore this review discusses the compilation of the work done on the use of M. citrifolia in livestock and poultry.

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Section: Growth Production and Imunomodulatory Properties In Livestockmentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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“…Calf health was evaluated through daily physical evaluations, which were recorded as health scores as previously described (Schäfer et al, 2008). Every animal received daily physical examinations, including observations on rectal temperature, ease of cough induction by manual compression of the trachea, fecal consistency, nasal discharge and presence and severity of ocular or otic abnormalities, which were aligned with specific respiratory, gastrointestinal (GI), and pyrexic disease events and subsequent predetermined medical treatment regimens.…”

Section: Methodsmentioning

confidence: 99%

“…Blood samples were allowed to clot for 18 hr at room temperature before the serum was removed and stored at 4 C. Serum samples were analyzed by the University of Wisconsin, School of Veterinary Medicine's clinical pathology laboratory. Calves with IgG levels  1000 mg/dL (Weaver et al, 2000;Schäfer et al, 2008), and total protein levels  5.0 g/dL were considered to have adequate passive transfer, and calves with lower levels were classified as having failure of passive transfer and subsequently removed from the trial. Calves were also removed from the trial if their starting weight did not fall between 32 and 54.5 kg, or if they died within 48 hr of arrival at the calf-raising farm.…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…The Morinda citrifolia (noni) fruit is a natural product with global equatorial distribution and established validated bioactive compounds that support its ethnoveterinary applications (Razafimandimbison et Previously, we examined the effects of feeding calves noni puree for the first 2 weeks of life on a parameter of innate immunity. Bacterial killing was evaluated via an ex vivo whole blood bactericidal assay (Schäfer et al, 2008). Noni supplemented calves showed significantly more killing power at day 14 when compared to control calves.…”

Section: Introductionmentioning

confidence: 99%

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Ethnoveterinary Application of Morinda Citrifolia Fruit Puree on a Commercial Heifer Rearing Facility with Endemic Salmonellosis

Brooks

Wolfe

Paulus

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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We have previously reported that Morinda citrifolia (noni) puree modulates neonatal calves developmental maturation of the innate and adaptive immune system. In this study, the effect of noni puree on respiratory and gastrointestinal (GI), health in preweaned dairy calves on a farm with endemic salmonellosis was examined. Two clinical trials were conducted whereby each trial evaluated one processing technique of noni puree. Trials 1 and 2 tested noni versions A and B, respectively. Puree analysis and trial methods were identical to each other, with the calf as the experimental unit. Calves were designated to 1 of 3 treatment groups in each trial and received either: 0, 15 or 30 mL every 12 hr of noni supplement for the first 3 weeks of life. Health scores, weaning age, weight gain from admission to weaning, and weaned by 6 weeks, were used as clinical endpoints for statistical analysis. In trial 1, calves supplemented with 15 mL noni puree of version A every 12 hr had a higher probability of being weaned by 6 weeks of age than control calves (P = 0.04). In trial 2, calves receiving 30 mL of version B every 12 hr had a 54.5% reduction in total medical treatments by 42 days of age when compared to controls (P = 0.02). There was a trend in reduced respiratory (61%), and GI (52%) medical treatments per calf when compared to controls (P = 0.06 and 0.08, respectively). There were no differences in weight gain or mortality for any treatment group in either trial.

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“…The documented effects of noni juice include anti-inflammatory, antiangiogenic, anticancer, antibacterial and antioxidant activities. Noni has been reported to modulate immune cells and has been found to enhance the adaptive immune response by activating T and B cells (9).…”

Section: Introductionmentioning

confidence: 99%

Antitumor activity of fermented noni exudates and its fractions

Chang

Wall

et al. 2012

Molecular and Clinical Oncology

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Abstract. Noni has been extensively used in folk medicine by Polynesians for over 2000 year. Recent studies have shown that noni has a wide spectrum of therapeutic activities including inhibition of angiogenesis, anti-inflammatory effects and anticancer activities. Intraperitoneal (i.p.) injection of fermented noni exudates (fNE) were previously found to induce significant tumor rejection in a S180 mouse sarcoma tumor model, while natural killer (NK) cells were demonstrated to be markedly involved in fNE-induced antitumor activity. In this study, fNE was partitioned into three fractions and their antitumor effects were examined using i.p. injection or as water supplement. The in vivo animal study results showed that when delivered by i.p. injection, n-butanol fraction of fNE (BuOH) effectively rejected (100%) tumor challenge and eradicated existing tumors (75%). When delivered as a water supplement, 62.5% of the mice receiving the n-butanol or ethyl acetate fractions resisted tumor cells. The tumor-resistant mice effectively rejected more and higher doses of tumor challenge, indicating that the immune system was activated. The findings confirm those of an earlier study showing fNE to have antitumor activity and demonstrating that the n-butanol fraction of fNE contains active antitumor components, to be further identified. More importantly, the antitumor effect of fNE and its fractions as water supplements renders a significant potential for identifying novel and powerful new dietary products for cancer prevention.

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Enhanced Bactericidal Activity against Escherichia coli in Calves Fed Morinda citrifolia (Noni) Puree

Cited by 21 publications

References 9 publications

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Ethnoveterinary Application of <em>Morinda Citrifolia</em> Fruit Puree on a Commercial Heifer Rearing Facility with Endemic <em>Salmonellosis</em>

Antitumor activity of fermented noni exudates and its fractions

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