Enhanced antitumour efficacy of functionalized doxorubicin plus schisandrin B co-delivery liposomes via inhibiting epithelial-mesenchymal transition

Cai, Fu-Yi; Yao, Xuemin; Jing, Ming; Kong, Liang; Liu, Jingjing; Fu, Min; Liu, Xin-Ze; Zhang, Lu; He, Siyu; Li, Xuetao; Ju, Rui-Jun

doi:10.1080/08982104.2020.1745831

Cited by 9 publications

(4 citation statements)

References 42 publications

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“…The cell death in tumor tissues can be efficiently reflected by TUNEL labeling. These results revealed that therapy with CUR-DTX-L could limit the growth of the tumor in a synergistic manner (Cai et al, 2021), which was consistent with the CCK-8 results.…”

Section: Histological Examination and Analysissupporting

confidence: 88%

Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin

Yang

Chen

et al. 2022

Front. Pharmacol.

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The successful treatment of breast cancer is hampered by toxicity to normal cells, impaired drug accumulation at the tumor site, and multidrug resistance. We designed a novel multifunctional liposome, CUR-DTX-L, to co-deliver curcumin (CUR) and the chemotherapeutic drug docetaxel (DTX) for the treatment of breast cancer in order to address multidrug resistance (MDR) and the low efficacy of chemotherapy. The mean particle size, polydispersity index, zeta potential, and encapsulation efficiency of CUR-DTX-L were 208.53 ± 6.82 nm, 0.055 ± 0.001, −23.1 ± 2.1 mV, and 98.32 ± 2.37%, respectively. An in vitro release study and CCK-8 assays showed that CUR-DTX-L has better sustained release effects and antitumor efficacy than free drugs, the antitumor efficacy was verified by MCF-7 tumor-bearing mice, the CUR-DTX-L showed better antitumor efficacy than other groups, and the in vivo pharmacokinetic study indicated that the plasma concentration–time curve, mean residence time, and biological half-life time of CUR-DTX-L were significantly increased compared with free drugs, suggesting that it is a promising drug delivery system for the synergistic treatment of breast cancer.

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Section: Histological Examination and Analysissupporting

confidence: 88%

Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin

Yang

Chen

et al. 2022

Front. Pharmacol.

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“…Sch B could inhibit the invasion and metastasis of lung cancer cells by inhibiting vascular endothelial growth factor. At the same time, it could also enhance the cytotoxicity of doxorubicin (DOX) and further promote cell apoptosis (Cai et al., 2020 ). β-ELE could inhibit cell proliferation, arrest cell cycle and induce apoptosis (Zhai et al., 2019 ).…”

Section: The Effect Of Natural Active Ingredients Combined With Chemo...mentioning

confidence: 99%

“…Some natural active ingredients can also directly decrease the side effects of chemotherapy drugs, improve the safety of clinical medication. Many natural active ingredients, such as berberine (BER) (Coelho et al., 2017 ; Wu et al., 2019b ), EGCG (Cheng et al., 2016 ), honokiol (Huang et al., 2017 ; Pillai et al., 2017 ; Huang et al., 2020 ), RES (Gu et al., 2018 ), glycyrrhizin (GL) ( Figure 1 ) (Lv et al., 2020 ), Que (Chen et al., 2019 ) and Sch B (Thandavarayan et al., 2015 ; Cai et al., 2020 ), could reduce DOX-induced cardiotoxicity. In addition, BER (Wang et al., 2021 ) could reduce irinotecan-induced gastrointestinal toxicity.…”

Section: The Effect Of Natural Active Ingredients Combined With Chemo...mentioning

confidence: 99%

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Shao

et al. 2022

Drug Delivery

103

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Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effect in multiple ways, abundant resources and less side effects. Therefore, the combination of natural active ingredients and chemotherapy drugs may be an effective antitumor strategy, which can inhibit the growth of tumor and multidrug resistance, reduce side effects of chemotherapy drugs. Nano-drug co-delivery system (NDCDS) can play an important role in the combination of natural active ingredients and chemotherapy drugs. This review provides a comprehensive summary of the research status and application prospect of nano-delivery strategies for the combination of natural active ingredients and chemotherapy drugs, aiming to provide a basis for the development of anti-tumor drugs.

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“…PFV modified liposomes effectively reduced the levels of VEGF, MMP9 and vimentin in breast cancer MDA-MB-435S cells (69). PFV modified schisandrin B and doxorubicin liposomes were also reported to be effective against non-small cell lung cancer cells (70).…”

Section: Nanotechnological Approaches For the Delivery Of Schisandrinmentioning

confidence: 98%

Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss"

Lin

Attar

Mobeen³

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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There has been an exponential growth in the field of molecular oncology and cutting-edge research has enabled us to develop a better understanding of therapeutically challenging nature of cancer. Based on the mechanistic insights garnered from decades of research, puzzling mysteries of multifaceted nature of cancer have been solved to a greater extent. Our rapidly evolving knowledge about deregulated oncogenic cell signaling pathways has allowed us to dissect different oncogenic transduction cascades which play critical role in cancer onset, progression and metastasis. Pharmacological targeting of deregulated pathways has attracted greater than ever attention in the recent years. Henceforth, discovery and identification of high-quality biologically active chemicals and products is gaining considerable momentum. There has been an explosion in the dimension of natural product research because of tremendous potential of chemopreventive and pharmaceutical significance of natural products. Schisandrin is mainly obtained from Schisandra chinensis. Schisandrin has been shown to be effective against different cancers because of its ability to inhibit/prevent cancer via modulation of different cell signaling pathways. Importantly, regulation of non-coding RNAs by schisandrin is an exciting area of research that still needs detailed and comprehensive research. However, we still have unresolved questions about pharmacological properties of schisandrin mainly in context of its regulatory role in TGF/SMAD, SHH/GLI, NOTCH and Hippo pathways.

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Enhanced antitumour efficacy of functionalized doxorubicin plus schisandrin B co-delivery liposomes via inhibiting epithelial-mesenchymal transition

Cited by 9 publications

References 42 publications

Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin

Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss"

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