Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Li, Bingqian; Shao, Huili; Li, Huan; Hua-gang, Sheng; Zhu, Lei

doi:10.1080/10717544.2022.2094498

Cited by 103 publications

(63 citation statements)

References 266 publications

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“…Due to the antitumor effect, abundant resources, multiple ways of action and few side effects, natural active ingredients have attracted more and more attention. It has been reported nanodrug co‐delivery system can play a critical role in the application of natural active products combined with chemotherapy drugs (Li et al, 2022). Thus, Rg3 combined with chemotherapy drugs may be an effective anti‐tumor strategy in the future to suppress the growth of tumor and multidrug resistance, and to reduce side effects of chemotherapeutics.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 alleviates the migration, invasion, and angiogenesis of lung cancer cells by inhibiting the expressions of cyclooxygenase‐2 and vascular endothelial growth factor

Xia

Huang

et al. 2023

Chem Biol Drug Des

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Lung cancer (LC) is a common cancer with high incidence and mortality rates. In recent years, ginsenoside Rg3 (Rg3), a traditional medicine, is widely used for the treatment of LC. Herein, we concentrate on assessing the effect of Rg3 on LC cell migration and invasion. The effects of Rg3 (0, 25, 50, and 100 μg/ml) on the viability, migration, invasion, angiogenesis, and expressions of epithelial–mesenchymal transition (EMT)‐related proteins, cyclooxygenase‐2 (COX2), and vascular endothelial growth factor (VEGF) of LC cell lines were evaluated by cell counting kit‐8 (CCK‐8), scratch, transwell, tube formation, and western blot assays. Quantitative real‐time polymerase chain reaction (qRT‐PCR) was performed to assess transfection efficiency. COX2 overexpression plasmid and short hairpin RNA for VEGF (shVEGF) were applied to evaluate whether the effect of Rg3 is related to COX2 and VEGF through rescue assay. In this study, Rg3 significantly dose‐dependently suppressed the viability, migration, invasion, angiogenesis, and protein expressions of N‐cadherin, vimentin, COX2, and VEGF in H1299 and A549 cells, while promoting the expression of E‐cadherin protein. COX2 overexpression markedly reversed the effects of Rg3 on the viability, migration, invasion, angiogenesis, and EMT‐related protein expression levels in LC cells; however, such effects of COX2 overexpression were offset by VEGF knockdown. In sum, Rg3 alleviates the migration, invasion, and angiogenesis of LC cells by inhibiting the expressions of COX2 and VEGF.

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 alleviates the migration, invasion, and angiogenesis of lung cancer cells by inhibiting the expressions of cyclooxygenase‐2 and vascular endothelial growth factor

Xia

Huang

et al. 2023

Chem Biol Drug Des

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“…Chemotherapy is the most commonly used treatment strategy in the clinical practice. Chemotherapeutics that are commonly used include doxorubicin (DOX), camptothecin (CPT), 5-FU, and curcumin (Cur), which are employed in the treatment of many cancers, including CRC [ 217 ]. However, chemotherapeutics have a number of limitations in their use, including rapid clearance after administration, non-specific distribution, and non-discriminatory damage to normal tissues [ 218 ].…”

Section: H 2 S Diagnosis and Treatment Strategies ...mentioning

confidence: 99%

Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

Lin¹,

Yang²,

Zhu³

et al. 2023

Redox Biology

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“…Up to present, it has been indeed achieved in substantive progress for cancer treatment by either chemotherapy small-molecular drugs or nucleic drugs; nevertheless, this malignant disease was still obstinate to be eliminated. This predicament may be attributed from the molecular and structural complexity of tumor, which cancers were regarded as various genetic disorders involved in multiple cells signaling [11][12][13]. So, it is possible that a single therapeutic strategy is insufficient to halt the progression of most cancers.…”

Section: Ivyspringmentioning

confidence: 99%

Advanced strategies for nucleic acids and small-molecular drugs in combined anticancer therapy

Qiu¹,

Wu²,

Shi³

et al. 2023

Int. J. Biol. Sci.

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Cancer has been considered as complex malignant consequence of genetic mutations that control the cellular proliferation, differentiation and homeostasis, thus making tumor treatment extremely challenging. To date, a variety of cargo molecules, including nucleic acids drugs (pDNA, miRNA and siRNA), therapeutic drugs (doxorubicin, paclitaxel, daunomycin and gefitinib) and imaging agents (radioisotopes, fluorescence dyes, and MRI contrast agents) have been regarded as the potential medicines in clinical application. However, non-single therapeutic drug could induce the satisfied clinical results because of tumor heterogeneity and multiple drug resistance and the nanotechnology-based combined therapy is becoming an advanced important mode for enhanced anticancer effects. The review gathers the current advanced development to co-deliver small-molecular drugs and nucleic acids for the anticancer therapy with nanomedicine-based combination. Furthermore, the superiority is definitely presented and the barriers are detail discussed to surmount the clinical challenges. In final, future perspectives in rational direction for combined tumor therapy of drugs and nucleic acids are exhibited.

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Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Cited by 103 publications

References 266 publications

Ginsenoside Rg3 alleviates the migration, invasion, and angiogenesis of lung cancer cells by inhibiting the expressions of cyclooxygenase‐2 and vascular endothelial growth factor

Ginsenoside Rg3 alleviates the migration, invasion, and angiogenesis of lung cancer cells by inhibiting the expressions of cyclooxygenase‐2 and vascular endothelial growth factor

Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

Advanced strategies for nucleic acids and small-molecular drugs in combined anticancer therapy

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