Enhanced antitumour effect of photodynamic therapy by microtubule inhibitors

W., L.; Berg, Kristian; Danielsen, Håvard E.; Kaalhus, Olav; Iani, Vladimir; Moan, Johan Emelian

doi:10.1016/s0304-3835(96)04437-0

Cited by 22 publications

(14 citation statements)

References 15 publications

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“…Several years ago, it was generically indicated that the combination of Adriamycin and Hematoporphyrin-Derivative/PDT may have potentiated the photodynamic effect in an in vivo transplantable mouse tumor assay [149]. More recently, Ma et al [150] demonstrated in a murine model that the combination of Meso-tetra(di-adjacent-sulfonatophenyl)-porphine/PDT with vincristine (a microtubule inhibitor), enhanced antitumor activity. However, it was reported that this favorable event occurred only when PDT was administered to animals within a defined time span.…”

Section: Current and Expected Approachesmentioning

confidence: 99%

Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview

Chiaviello

Postiglione

Palumbo

2011

Cancers

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Lung cancer remains one of the most common cancer-related causes of death. This type of cancer typically develops over a period of many years, and if detected at an early enough stage can be eliminated by a variety of treatments including photodynamic therapy (PDT). A critical discussion on the clinical applications of PDT in lung cancer is well outside the scope of the present report, which, in turn focuses on mechanistic and other aspects of the photodynamic action at a molecular and cellular level. The knowledge of these issues at pre-clinical levels is necessary to develop, check and adopt appropriate clinical protocols in the future. This report, besides providing general information, includes a brief overview of present experimental PDT and provides some non-exhaustive information on current strategies aimed at further improving the efficacy, especially in regard to lung cancer cells.

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Section: Current and Expected Approachesmentioning

confidence: 99%

Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview

Chiaviello

Postiglione

Palumbo

2011

Cancers

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“…As a consequence of the mitotic blockage, cells finally go to apoptosis by the so-called mitotic catastrophe [306,307]. Several published results have demonstrated that MTs are implicated in cell killing by PDT with different PSs, such as thiazines (methylene blue, toluidine blue), carbocyanines (DiOC 6 (3)), porphyrins (Photofrin, TMPyP, meso-tetraphenylporphine sulfonates, BPD-MA, mesotetra(3-hydroxyphenyl) porphine), phthalocyanines (ZnPc, Al(III)-phthalocyanine tetrasulfonate), and porphycenes (TPPo, PdTPPo) [43,67,69,247,[308][309][310][311][312][313][314][315]. The described MT alterations clearly depend on the different experimental conditions [36,44,45].…”

Section: Photodamage To Cell Structuresmentioning

confidence: 99%

Porphycenes: Facts and Prospects in Photodynamic Therapy of Cancer

Stockert¹,

Cañete²,

Juarranz³

et al. 2007

CMC

177

130

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The photodynamic process induces cell damage and death by the combined effect of a photosensitizer (PS), visible light, and molecular oxygen, which generate singlet oxygen ((1)O(2)) and other reactive oxygen species that are responsible for cytotoxicity. The most important application of this process with increasing biomedical interest is the photodynamic therapy (PDT) of cancer. In addition to hematoporphyrin-based drugs, 2nd generation PSs with better photochemical properties are now studied using cell cultures, experimental tumors and clinical trials. Porphycene is a structural isomer of porphyrin and constitutes an interesting new class of PS. Porphycene derivatives show higher absorption than porphyrins in the red spectral region (lambda > 600 nm, epsilon > 50000 M-(1)cm(-1)) owing to the lower molecular symmetry. Photophysical and photobiological properties of porphycenes make them excellent candidates as PSs, showing fast uptake and diverse subcellular localizations (mainly membranous organelles). Several tetraalkylporphycenes and the tetraphenyl derivative (TPPo) induce photodamage and cell death in vitro. Photodynamic treatments of cultured tumor cells with TPPo and its palladium(II) complex induce cytoskeletal changes, mitotic blockage, and dose-dependent apoptotic or necrotic cell death. Some pharmacokinetic and phototherapeutic studies on experimental tumors after intravenous or topical application of lipophilic alkyl-substituted porphycene derivatives are known. Taking into account all these features, porphycene PSs should be very useful for PDT of cancer and other biomedical applications.

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“…262 Similarly, the combination of taxol chemotherapy and mesotetrakis(di-adj-sulphonatophenyl)porphyrin (TPPS2) PDT resulted in significantly higher retardation of tumor growth in mouse mammary tumor model than application of individual therapies. 263 Other known widely used drugs are cisplatin [cis-diamine-dichloroplatinum(II)] and its derivatives (oxaliplatin and carboplatin). Their anticancer effect is based on the formation of DNA adducts, subsequent blocking of mitoses and induction of apoptosis sequence.…”

Section: Porphyrin and Expanded Porphyrin Applications For Combinementioning

confidence: 99%

Design, Synthesis, Selective Recognition Properties and Targeted Drug Delivery Application

Králová¹,

Kejík²,

Břı́za³

et al. 2014

Handbook of Porphyrin Science

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Enhanced antitumour effect of photodynamic therapy by microtubule inhibitors

Cited by 22 publications

References 15 publications

Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview

Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview

Porphycenes: Facts and Prospects in Photodynamic Therapy of Cancer

Design, Synthesis, Selective Recognition Properties and Targeted Drug Delivery Application

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