Enhanced antibacterial activity of roxithromycin loaded pegylated poly lactide-co-glycolide nanoparticles

Koopaei, Mona Noori; Maghazei, Mohamad Shahab; Mostafavi, Seyed Hossein; Jamalifar, Hossein; Samadi, Nasrin; Amini, Mohsen; Malek, Soheyl Jafari; Darvishi, Behrad; Atyabi, Fatemeh; Dinarvand, Rassoul

doi:10.1186/2008-2231-20-92

Cited by 22 publications

(15 citation statements)

References 17 publications

(21 reference statements)

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“…In contrast, the PLGA/GO NPs have much smaller particle sizes that increased the surface area, leading to an increase in the contact of GO with the bacterial cell wall. The efficiency of GO NPs in inhibiting bacterial growth could possibly be due to a few reasons: (1) the NPs were able to fuse to the bacterial cell wall, releasing the conjugated GO across the cell wall; (2) NPs were able to penetrate into the bacterial cells due to their large surface areas; (3) improving the hydrophilicity of GO leads to better delivery of GO to its site of action; and (4) the degree of diffusion of the GO NPs through the bacteria was higher than for the GO bulk form . Furthermore, it is obvious that there is no remarkable difference in the antibacterial activities of the NPs prepared at homogenization times of 10 and 15 min.…”

Section: Resultsmentioning

confidence: 99%

Garlic oil–loaded PLGA nanoparticles with controllable size and shape and enhanced antibacterial activities

Fahmy

Mamdouh

2018

J of Applied Polymer Sci

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The present work focuses on producing polymer composite nanoparticles (NPs) composed of garlic oil (GO) and poly (lactic-co-glycolic) acid (PLGA) by the single emulsion/solvent evaporation (SE/SE) method and high-speed homogenizing. Different preparation parameters were found to greatly affect the stability and size uniformity of the prepared PLGA/GO NP formulations, which were carefully controlled. Scanning electron microscopy, Fourier transform infrared spectroscopy, and UV-vis spectroscopy and dynamic light scattering and zeta potential were used to characterize the NPs. Antibacterial assessment of the prepared PLGA/GO NPs against E. coli and S. aureus was carried out. Interestingly, the NP size ranged between 201 and 319 nm, which is 10 times less than the size of the regular GO particles in bulk solution. The antibacterial activities show enhancement by 70-78% of bacterial inhibition compared with a GO bulk solution. This work sheds light on the potential use of GO NP formulations as nanobiotics and the critical NP preparation parameters that need to be considered.

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Section: Resultsmentioning

confidence: 99%

Garlic oil–loaded PLGA nanoparticles with controllable size and shape and enhanced antibacterial activities

Fahmy

Mamdouh

2018

J of Applied Polymer Sci

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“…[ 63 ] Thus, it has been shown that the toxicity of copper oxide [ 62 ] and magnesium oxide [ 64 ] NPs increased when their size decreased, whatever the bacterial species used. To our knowledge, the antibacterial effect of PLGA‐NPs has never been investigated up to now, and some previous works on micrometric PLGA particles (from 100 nm to 50 µm) showed that they had no antibacterial effect, on S. aureus , [ 55 ] Staphylococcus epidermidis , [ 65 ] Bacillus subtilis , [ 65 ] Escherichia coli , [ 44 ] Salmonella typhimurium , [ 43 ] and Brucella . [ 66 ] The detailed antibacterial mechanisms of NPs have not been thoroughly explained.…”

Section: Figurementioning

confidence: 99%

Antibacterial Activity of Ciprofloxacin‐Loaded Poly(lactic‐co‐glycolic acid)‐Nanoparticles Against Staphylococcus aureus

Gheffar

Jouenne

et al. 2020

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pneumonia, ENT (ear, nose, and throat) pathologies, biliary tract pathologies, urinary tract infections, chronic wounds, nosocomial diseases, etc.). Biofilms are also involved in infections of implanted medical devices, for example, prostheses, vascular catheters, heart valves, ventricular shunts, oro-tracheal tubes, and catheters. [8-10] The percentage of patients contracting nosocomial illness during their hospital stay is estimated at a little more than 7% in developed countries and 10% in developing countries. [11] Different approaches are already used to fight against microbial growth on materials: [12-15] (i) a prophylactic one consists of preventing the bacterial attachment on the materials [16-18] and (ii) a curative one which aims to destroy the preformed biofilm. [19,20] The latter remains a real challenge because sessile bacteria exhibit a high multifactorial resistance to antimicrobials. [19,21,22] Despite the implementation by the World Health Organization (WHO) of different strategies to control the emergence of antimicrobial resistance (AMR) (prevention of transmission and importation of resistant bacteria, control of antibiotic consumption), AMR has reached a critical level. [23] The main problem is the poor development of newly designed antibiotic molecules due to its high costs. Thus, it is mostly new generations of already known antibiotic which appeared on the market these last decades. [24,25] If AMR is not tackled, annual loss of life is expected to reach 10 million deaths by 2050 with an estimated economic cost between 60 and 100 trillion USD. [26] Consequently, new antimicrobial strategies must be urgently found in the near future. In this context, numerous governmental and industrial programs aiming to search new antibiotics are being implemented. [24,25,27] WHO and Drugs for Neglected Diseases initiated in 2016, the Global Antibiotic Research and Development Partnership (GARDP) project with the aim to develop new treatments by either improving existing antibiotics or developing new chemical entities by 2023. [28] In parallel, WHO defined in 2015, the Global Antimicrobial Resistance Surveillance System (GLASS) to foster AMR surveillance via a standardized approach to the collection, analysis, and sharing of data by countries. [29] The formation of bacterial biofilms on material surfaces is a recurrent problem in public health. Antibacterial nanoparticles (NPs) are promising because pathogens have not yet developed resistance mechanisms and encapsulation of the drug can protect it from the surrounding medium and improve pharmacokinetics. Biocompatible and biodegradable particles of various sizes (nano-and micro-scale) based on poly(lactic-co-glycolic acid) (PLGA) are elaborated using a simple and free toxic nanoprecipitation process. Particles are poly(ethylene glycol) (PEG)-ylated in order to reduce unwanted interactions with biological fluids, or loaded with the large spectrum antibiotic ciprofloxacin (CIP). NPs are studied against Staphylococcus aureus in planktonic and biofilm modes. E...

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“…A major interest in this area is to improve drug targeting towards tumor cells and decrease the unwilling effects of chemotherapeutics [ 1 - 3 ]. Nanotechnology is very promising in this field and increases the efficacy of targeting by introducing passive and active targeting [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Improved anticancer delivery of paclitaxel by albumin surface modification of PLGA nanoparticles

et al. 2015

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BackgroundNanoparticles (NPs) play an important role in anticancer delivery systems. Surface modified NPs with hydrophilic polymers such as human serum albumin (HSA) have long half-life in the blood circulation system.MethodsThe method of modified nanoprecipitation was utilized for encapsulation of paclitaxel (PTX) in poly (lactic-co-glycolic acid) (PLGA). Para-maleimide benzoic hydrazide was conjugated to PLGA for the surface modifications of PLGA NPs, and then HSA was attached on the surface of prepared NPs by maleimide attachment to thiol groups (cysteines) of albumin. The application of HSA provides for the longer blood circulation of stealth NPs due to their escape from reticuloendothelial system (RES). Then the physicochemical properties of NPs like surface morphology, size, zeta potential, and in-vitro drug release were analyzed.ResultsThe particle size of NPs ranged from 170 to 190 nm and increased about 20–30 nm after HSA conjugation. The zeta potential was about -6 mV and it decreased further after HSA conjugation. The HSA conjugation in prepared NPs was proved by Fourier transform infrared (FT-IR) spectroscopy, faster degradation of HSA in Differential scanning calorimetry (DSC) characterization, and other evidences such as the increasing in size and the decreasing in zeta potential. The PTX released in a biphasic mode for all colloidal suspensions. A sustained release profile for approximately 33 days was detected after a burst effect of the loaded drug. The in vitro cytotoxicity evaluation also indicated that the HSA NPs are more cytotoxic than plain NPs.ConclusionsHSA decoration of PLGA NPs may be a suitable method for longer blood circulation of NPs.

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Enhanced antibacterial activity of roxithromycin loaded pegylated poly lactide-co-glycolide nanoparticles

Cited by 22 publications

References 17 publications

Garlic oil–loaded PLGA nanoparticles with controllable size and shape and enhanced antibacterial activities

Garlic oil–loaded PLGA nanoparticles with controllable size and shape and enhanced antibacterial activities

Antibacterial Activity of Ciprofloxacin‐Loaded Poly(lactic‐co‐glycolic acid)‐Nanoparticles Against Staphylococcus aureus

Improved anticancer delivery of paclitaxel by albumin surface modification of PLGA nanoparticles

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