Enhanced antibacterial activity of PEO-chitosan nanofibers with potential application in burn infection management

Abid, Sharjeel; Hussain, Tanveer; Zahir, Abdul; Ramakrishna, Seeram; Hameed, Misbah; Khenoussi, Nabyl

doi:10.1016/j.ijbiomac.2019.06.022

Cited by 84 publications

(43 citation statements)

References 93 publications

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“…Intensive study of PEO behavior during the electrospinning process has been undertaken due to this fact and because of the excellent biodegradability, biocompatibility, and non-toxicity. These attributes also reflect PEO nanofiber applications in biomedicine and the food industry [7][8][9][10] apart from the above already mentioned improvements in spinnability in combination with chitin or chitosan [11][12][13][14], keratin [15,16], silk [17,18] and other materials.…”

Section: Introductionmentioning

confidence: 92%

Characterization of Poly(Ethylene Oxide) Nanofibers—Mutual Relations between Mean Diameter of Electrospun Nanofibers and Solution Characteristics

Filip

Peer

2019

Processes

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† This paper is an expanded version of "Electrospinning of poly(ethylene oxide) solutions-Quantitative relations between mean nanofibre diameter, concentration, molecular weight, and viscosity " published in Abstract: The quality of electrospun poly(ethylene oxide) (PEO) nanofibrous mats are subject to a variety of input parameters. In this study, three parameters were chosen: molecular weight of PEO (100, 300, 600, and 1000 kg/mol), PEO concentration (in distilled water), and shear viscosity of PEO solution. Two relations free of any adjustable parameters were derived. The first, describing the initial stage of an electrospinning process expressing shear viscosity using PEO molecular weight and concentration. The second, expressing mean nanofiber diameter using concentration and PEO molecular weight. Based on these simple mathematical relations, it is possible to control the mean nanofiber diameter during an electrospinning process.

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Section: Introductionmentioning

confidence: 92%

Characterization of Poly(Ethylene Oxide) Nanofibers—Mutual Relations between Mean Diameter of Electrospun Nanofibers and Solution Characteristics

Filip

Peer

2019

Processes

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“…Moreover, both PVA and PEO are easily electrospinnable because of their high molecular weight and viscosity. Thus, there have been many studies on the composite nanofibers of PVA-and PEO-blended with keratin [10,11], soy protein [12,13], whey protein isolates [14,15], alginates [16,17], and chitosan [18][19][20]. Importantly, blending modification with PVA or PEO can significantly facilitate the electrospinning process for polymers that do not have sufficient entanglement or interactions for electrospinning [21].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Silver Nanoparticles-Embedded Feather Keratin/Poly(vinyl alcohol)/Poly(ethylene oxide) Antibacterial Composite Nanofibers

Chen

Dou

et al. 2020

Polymers

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Feathers, which contain >90% keratin, are valuable natural protein resources. The aim of this study is to prepare antimicrobial feather keratin (FK)-based nanofibers by incorporating silver nanoparticles (AgNPs). A series of AgNPs-embedded feather keratin/poly(vinyl alcohol)/poly(ethylene oxide) (FK/PVA/PEO) composite nanofibers with varying amounts of AgNPs content were fabricated by electrospinning. Their morphology, crystallinity, thermal stability, tensile property, and antibacterial activity were systematically investigated. The average diameters of composite nanofibers gradually decreased with increases in the amount of AgNPs. The crystallinity, thermal stability, and antibacterial activity of FK/PVA/PEO nanofibers were enhanced by embedding AgNPs. When embedded with 1.2% AgNPs, both the tensile strength and elongation-at-break reached the highest level. This work has the potential to expand the application of FK-based nanofibers in the biomaterial field.

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“…The results showed that the nanofiber membranes without emodin had the maximum swelling ratio of 29.5%, while the emodin-loaded nanofiber membranes showed swelling ratio of 167.8%, which indicated the presence of emodin showed a noticeable effect on the membrane swelling. This significant increment in SW% (p < 0.001) could be attributed to the increased hydrogen bonding between the water molecules and emodin [42]. The good swelling property of emodin-loaded nanofibers could maintain a better wound-healing environment.…”

Section: Swelling Ratiomentioning

confidence: 93%

Long-Term Effect against Methicillin-Resistant Staphylococcus aureus of Emodin Released from Coaxial Electrospinning Nanofiber Membranes with a Biphasic Profile

Wei

Luo

et al. 2020

Biomolecules

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Methicillin-resistant Staphylococcus aureus (MRSA) is a serious and rapidly growing threat to human beings. Emodin has a potent activity against MRSA; however, its usage is limited due to high hydrophobicity and low oral bioavailability. Thus, the coaxial electrospinning nanofibers encapsulating emodin in the core of hydrophilic poly (vinylpyrrolidone), with a hygroscopic cellulose acetate sheath, have been fabricated to provide long-term effect against MRSA. Scanning electron microscopy and transmission electron microscopy confirmed the nanofibers had a linear morphology with nanometer in diameter, smooth surface, and core-shell structure. Attenuated total reflection-Fourier transform infrared spectra, X-ray diffraction patterns, and differential scanning calorimetric analyses verified emodin existed in amorphous form in the nanofibers. The nanofibers have 99.38 ± 1.00% entrapment efficiency of emodin and 167.8 ± 0.20% swelling ratio. Emodin released from nanofibers showed a biphasic drug release profile with an initial rapid release followed by a slower sustained release. CCK-8 assays confirmed the nontoxic nature of the emodin-loaded nanofibers to HaCaT cells. The anti-MRSA activity of the nanofibers can persist up to 9 days in AATCC147 and soft-agar overlay assays. These findings suggest that the emodin-loaded electrospun nanofibers with core-shell structure could be used as topical drug delivery system for wound infected by MRSA.

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Enhanced antibacterial activity of PEO-chitosan nanofibers with potential application in burn infection management

Cited by 84 publications

References 93 publications

Characterization of Poly(Ethylene Oxide) Nanofibers—Mutual Relations between Mean Diameter of Electrospun Nanofibers and Solution Characteristics

Characterization of Poly(Ethylene Oxide) Nanofibers—Mutual Relations between Mean Diameter of Electrospun Nanofibers and Solution Characteristics

Electrospun Silver Nanoparticles-Embedded Feather Keratin/Poly(vinyl alcohol)/Poly(ethylene oxide) Antibacterial Composite Nanofibers

Long-Term Effect against Methicillin-Resistant Staphylococcus aureus of Emodin Released from Coaxial Electrospinning Nanofiber Membranes with a Biphasic Profile

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