Long-Term Effect against Methicillin-Resistant Staphylococcus aureus of Emodin Released from Coaxial Electrospinning Nanofiber Membranes with a Biphasic Profile

Ye, Peiwen; Wei, Suying; Luo, Chaohua; Wang, Qirui; Li, Anzhang; Wei, Fei

doi:10.3390/biom10030362

Cited by 49 publications

(18 citation statements)

References 43 publications

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“…This was further confirmed by UV-vis spectra (Figure 1c). These three methods were favorable measurements to verify the linkage of Em with MNPs, which was also used in other studies [22,23].…”

Section: Characterization Of Plga-b-mpeg and Em-mnpsmentioning

confidence: 96%

Mesoscale nanoparticles encapsulated with emodin for targeting antifibrosis in animal models

et al. 2020

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The aim of this study is to explore the kidney-targeting capability of mesoscale nanoparticles (MNPs)-emodin (Em-MNPs) and its potential antifibrosis in the animal model. First, MNPs and Em-MNPs were synthesized via nanoprecipitation method, and their diameters were both ∼400 nm with the uniform size. The entrapment efficiency of MNPs was 45.1% when adding emodin at the concentration of 12 mg/mL. Moreover, cytotoxicity assay showed that Em-MNPs presented excellent biocompatibility in rat proximal tubular cells. Cellular uptake assay demonstrated that Em-MNPs had high-efficiency uptake, especially in the cytoplasm. Ex vivo organ fluorescence imaging revealed that Em-MNPs possessed specific kidney-targeting ability with relative long retention time in the kidney (∼24 h). In the renal unilateral ureteral obstruction model, Em-MNPs treatment could significantly alleviate kidney tubule injury and reduce extracellular matrix deposition compared with free MNPs. Herein, Em-MNPs with specific kidney-targeting and preferable antifibrosis effects in animal model may pave an avenue for treating renal diseases.

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Section: Characterization Of Plga-b-mpeg and Em-mnpsmentioning

confidence: 96%

Mesoscale nanoparticles encapsulated with emodin for targeting antifibrosis in animal models

et al. 2020

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“…Besides, emodin-loaded poly (DL-lactide-co-glycolide)/Eudragit Ⓡ S100/montmorillonite nanoparticles specifically released emodin in the diseased colon, thus effectively suppressed ulcerative colitis-related immune-inflammatory responses [ 209 ]. Gelatin-cyclodextrin, poly(vinyl pyrrolidone), and cellulose acetate were also applied to assembly-load emodin into different anti-bacteria nanoagent to effectively inhibit the growth of S. suis and MRSA [ 210 , 211 ]. In addition, it has been reported that loading emodin on nanosilver, an efficacious antimicrobial agent, significantly protected against cecal ligation and puncture-induced sepsis in vitro and in vivo, by halting gut-microbiota-mediated systemic infection [ 212 ].…”

Section: Modification Of Emodin For Better Therapeutic Potentialmentioning

confidence: 99%

Advances in the study of emodin: an update on pharmacological properties and mechanistic basis

Zheng

et al. 2021

Chin Med

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Rhei Radix et Rhizoma, also known as rhubarb or Da Huang, has been widely used as a spice and as traditional herbal medicine for centuries, and is currently marketed in China as the principal herbs in various prescriptions, such as Da-Huang-Zhe-Chong pills and Da-Huang-Qing-Wei pills. Emodin, a major bioactive anthraquinone derivative extracted from rhubarb, represents multiple health benefits in the treatment of a host of diseases, such as immune-inflammatory abnormality, tumor progression, bacterial or viral infections, and metabolic syndrome. Emerging evidence has made great strides in clarifying the multi-targeting therapeutic mechanisms underlying the efficacious therapeutic potential of emodin, including anti-inflammatory, immunomodulatory, anti-fibrosis, anti-tumor, anti-viral, anti-bacterial, and anti-diabetic properties. This comprehensive review aims to provide an updated summary of recent developments on these pharmacological efficacies and molecular mechanisms of emodin, with a focus on the underlying molecular targets and signaling networks. We also reviewed recent attempts to improve the pharmacokinetic properties and biological activities of emodin by structural modification and novel material-based targeted delivery. In conclusion, emodin still has great potential to become promising therapeutic options to immune and inflammation abnormality, organ fibrosis, common malignancy, pathogenic bacteria or virus infections, and endocrine disease or disorder. Scientifically addressing concerns regarding the poor bioavailability and vague molecular targets would significantly contribute to the widespread acceptance of rhubarb not only as a dietary supplement in food flavorings and colorings but also as a health-promoting TCM in the coming years.

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“…For improving the drug sustained release profile, the after-treatment of cross-linking was exploited on those electrospun nanofibers. With the progress made of electrospinning itself, more and more strategies have been developed for furnishing all types of drug controlled release profiles, including pulsatile, biphasic, targeted, and drug sustained release [ 50 , 51 , 52 , 53 , 54 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

et al. 2021

Biomolecules

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The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug—metformin hydrochloride (MET). The core–sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process—nanostructure–performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core–sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.

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Long-Term Effect against Methicillin-Resistant Staphylococcus aureus of Emodin Released from Coaxial Electrospinning Nanofiber Membranes with a Biphasic Profile

Cited by 49 publications

References 43 publications

Mesoscale nanoparticles encapsulated with emodin for targeting antifibrosis in animal models

Mesoscale nanoparticles encapsulated with emodin for targeting antifibrosis in animal models

Advances in the study of emodin: an update on pharmacological properties and mechanistic basis

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

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