Enhanced antibacterial activity and biocompatibility of zinc-incorporated organic-inorganic nanocomposite coatings via electrophoretic deposition

Huang, Pin; Ma, Kun; Cai, Xinjie; Huang, Dan; Yang, Xu; Ran, Jiabing; Wang, Fushi; Jiang, Tao

doi:10.1016/j.colsurfb.2017.10.012

Cited by 30 publications

(16 citation statements)

References 52 publications

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“…ZnO NPs have drawn considerable attention and widely used in drug delivery system (Dhivya, Ranjani, Rajendhran, Rajasekaran, & Annaraj, 2015), biosensor construction (Xiong, 2013), and antibacterial studies (Liu, Wang, Ma, Peng, & Wang, 2019; Mao et al, 2017), owing to their pH‐responsive property, tunable shape and pore size, catalytic property, and good biodegradability (Li et al, 2017; Sirelkhatim et al, 2015; Zhang, Nayak, Hong, & Cai, 2013). Meanwhile, ZnO NPs could be dissolved intracellularly owing to the more acidic environment of endosome/lysosome, and leading to drug release for cancer therapy (Huang et al, 2017; Kuang et al, 2019). Moreover, the uncontrolled rapid release of Zn 2+ could be easily untaken by cells and the effects of Zn 2+ on osteogenesis stimulation have been approved in bone formation (Ishikawa et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Yang

Tao

Gong

et al. 2020

J Biomedical Materials Res

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After bone tumor resection, the large bony deficits are commonly reconstructed with Ti‐based metallic endoprosthesis, which provide immediate stable fixation and allow early ambulation and weight bearing. However, when used in osteosarcoma resection, Ti implant‐relative infection and tumor recurrence were recognized as the two critical factors for implantation failure. Hence, in this work, a novel zinc oxide nanoparticle decorating with naringin was prepared and immobilized onto Ti substrate. The drugs delivery profiles proved that in the bacterial infection and Warburg effect of osteosarcoma‐induced acidic condition, naringin and Zn2+ can be released easily from the functional Ti substrate. The anti‐osteosarcoma and antibacterial assay showed the delivered naringin and Zn2+ can induce a remarkable increase of oxidative stress in bacteria (Escherichia coli and Staphylococcus aureus) and osteosarcoma (Saos‐2 cells) by producing reactive oxygen species (ROS). Accumulation of ROS results in damage of bacterial biofilm and bacterial membrane, leading to the leakage of bacterial RNA and DNA. Meanwhile, the increase of ROS induces osteosarcoma cell apoptosis by activating ROS/extracellular signal‐regulated kinase signaling pathway. Furthermore, in vitro cellular experiments, including cell viability, alkaline phosphatase activity, collagen secretion, extracellular matrix mineralization level, indicated that the functional Ti substrate exhibited great potential for osteoblasts proliferation and differentiation. Hence, this study provides a simple and promising strategy of developing multifunctional Ti‐based implants for the reconstruction of large bony after osteosarcoma resection.

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Section: Introductionmentioning

confidence: 99%

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Yang

Tao

Gong

et al. 2020

J Biomedical Materials Res

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“…Owing to its superior antibacterial effect and osteogenic effect, Zn-based treatment of implant-related infection has gained increasing interest. Huang et al used electrophoretic deposition technology to load Zn into chitosan/gelatin nanocomposite coatings, which not only provided good antibacterial effect against E. coli and S. aureus but also promoted the proliferation and osteogenic activity of bone marrow mesenchymal stem cells in vitro [109]. ZnNPs have excellent antibacterial effect, but their potential toxicity and aggregation tendency have limited their application to some extent.…”

Section: Controlled Release Of Antimicrobial Agents Against Planktonimentioning

confidence: 99%

Surface treatment strategies to combat implant-related infection from the beginning

Wang

Tang

2019

Journal of Orthopaedic Translation

106

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Orthopaedic implants are recognised as important therapeutic devices in the successful clinical management of a wide range of orthopaedic conditions. However, implant-related infections remain a challenging and not uncommon issue in patients with implanted instrumentation or medical devices. Bacterial adhesion and formation of biofilm on the surface of the implant represent important processes towards progression of infection. Given the intimate association between infection and the implant surface, adequate treatment of the implant surface may help mitigate the risk of infection. This review summarises the current surface treatment technologies and their role in prevention of implant-related infection from the beginning. Translational potential of this article Despite great technological advancements, the prevalence of implant-related infections remains high. Four main challenges can be identified. (i) Insufficient mechanical stability can cause detachment of the implant surface coating, altering the antimicrobial ability of functionalized surfaces. (ii) Regarding drug-loaded coatings, a stable drug release profile is of vital importance for achieving effective bactericidal effect locally; however, burst release of the loaded antibacterial agents remains common. (iii) Although many coatings and modified surfaces provide superior antibacterial action, such functionalisation of surfaces sometimes has a detrimental effect on tissue biocompatibility, impairing the integration of the implants into the surrounding tissue. (iv) Biofilm eradication at the implant surface remains particularly challenging. This review summarised the recent progress made to address the aforementioned problems. By providing a perspective on state-of-the-art surface treatment strategies for medical implants, we hope to support the timely adoption of modern materials and techniques into clinical practice.

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“…The antibacterial activity of chitosan depends on its concentration, molecular weight, the degree of deacetylation, and the type of bacteria [35,[48][49][50][51][52]. However, cashmere fibers themselves do not show any antibacterial properties and easily breed bacteria.…”

Section: Antibacterial Activity Of Ocgcfmentioning

confidence: 99%

Structure and Properties of Oxidized Chitosan Grafted Cashmere Fiber by Amide Covalent Modification

Fang

Yan

et al. 2020

Molecules

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In this study, oxidized chitosan grafted cashmere fibers (OCGCFs) were obtained by crosslinking the oxidized chitosan onto cashmere fibers by amide covalent modification. A novel method was developed for the selective oxidation of the C6 primary hydroxyls into carboxyl groups for chitosan. The effect of oxidization reaction parameters of HNO3/H3PO4–NaNO2 mediated oxidation system on the oxidation degree, structure, and properties of chitosan were investigated. The chemical structure of the oxidized chitosan was characterized by solid-state cross-polarization magic angle spinning carbon-13 Nuclear Magnetic Resonance (CP/MAS 13C-NMR), Fourier transform infrared spectroscopy (FT-IR), and its morphology was investigated by scanning electron microscopy (SEM). Subsequently, the effect of the oxidized chitosan grafting on OCGCF was examined, and the physical properties, moisture regain, and antibacterial activity of OCGCFs were also evaluated. The results showed that oxidation of chitosan mostly occurred at the C6 primary hydroxyl groups. Moreover, an oxidized chitosan with 43.5–56.8% carboxyl content was realized by ranging the oxidation time from 30 to 180 min. The resulting OCGCF had a C–N amido bond, formed as a result of the reaction between the primary amines in the cashmere fibers and the carboxyl groups in the oxidized chitosan through the amide reaction. The OCGCF exhibited good moisture regain and remarkable bacteriostasis against both Staphylococcus aureus and Escherichia coli bacteria with its durability.

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Enhanced antibacterial activity and biocompatibility of zinc-incorporated organic-inorganic nanocomposite coatings via electrophoretic deposition

Cited by 30 publications

References 52 publications

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Surface treatment strategies to combat implant-related infection from the beginning

Structure and Properties of Oxidized Chitosan Grafted Cashmere Fiber by Amide Covalent Modification

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