Enhanced Anti-corrosion Ability and Biocompatibility of PLGA Coatings on MgZnYNd Alloy by BTSE-APTES Pre-treatment for Cardiovascular Stent

Jing, Liu; Xi, Tao

doi:10.1016/j.jmst.2016.06.021

Cited by 47 publications

(16 citation statements)

References 73 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the prepared silane coatings had satisfactory biocompatibilities, such as increased cell viability (HUVECs), reduced hemolysis, and platelet adhesion. Moreover, the formation of the Mg- O -Si- bond in the silane coating can powerfully enhance the interfacial compatibility between inorganic and organic materials [ 172 ]. Furthermore, the active groups of silane coating can conjugate the functional groups of the bioactive molecules [ 173 ].…”

Section: Surface Modification Of Mg Alloy Stentsmentioning

confidence: 99%

“…Also, the coating showed excellent biocompatibility [ 170 ]. ZE21B BTSE-APTES-PLGA 6.4 ± 0.4 Hank's −1.396 −0.405 31.91 7.148 0.729 0.163 30 BTSE-APTES-PLGA coating exhibited both improved anti-corrosion ability and biocompatibility for cardiovascular stent implants [ 172 ]. ZE21B PDA/HA – SBF −1.6491 −1.5715 103.4 1.303 2.362 0.029 15 PDA/HA displayed better hemocompatibility, pro-endothelialization, anti-hyperplasia, and anti-inflammation functions in vitro, PDA/HA coating had preferable corrosion resistance and biocompatibility in vivo [ 194 ].…”

Section: Surface Modification Of Mg Alloy Stentsmentioning

confidence: 99%

See 1 more Smart Citation

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

show abstract

Section: Surface Modification Of Mg Alloy Stentsmentioning

confidence: 99%

Section: Surface Modification Of Mg Alloy Stentsmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

show abstract

“…The over-fast degradation rate of Mg-based alloys in the human physiological environment with a large amount of chloride ions, sulfate ions and carbonate ions will lead to the failure of Mg-based materials before fulfilling the expectant function. 5,6 The poor anti-corrosion ability accompanied by local accumulation of hydrogen (H 2 ) and alkaline ions will affect cell adhere onto the implant surface and cause the local tissue and organ inflammation even necrosis in severe cases 7 and has become the main obstacle for potential clinical application of Mg-based alloys. Moreover, the thrombus caused by endothelium injury remains a problem.…”

Section: Introductionmentioning

confidence: 99%

Layered hydroxide/polydopamine/hyaluronic acid functionalized magnesium alloys for enhanced anticorrosion, biocompatibility and antithrombogenicity in vascular stents

Zhang

Pei

et al. 2020

J Biomater Appl

View full text Add to dashboard Cite

Magnesium alloys are promising cardiovascular stent materials due to the favourable physical properties and complete biodegradability in vivo. However, the rapid degradation, poor cytocompatibility and tendency of thrombogenesis hinder practical clinical applications. In order to solve these problems, a facile and highly efficient strategy of alkali treatment combined with subsequent layer-by-layer assembly was used to fabricate a multifunctional coating. A bottom layer hydroxyl (–OH) with negative charge after alkali treatment first formed a solid bond with magnesium matrix to provide a rough outer surface for the further immobilization of functional biomolecules. Afterwards, polydopamine and hyaluronic acid were successively immobilized on alkali-treated magnesium surface via strong electrostatic adsorption and covalent bonding between carboxyl group of hyaluronic acid and amine or hydroxyl of polydopamine to form magnesium/OH/polydopamine/hyaluronic acid. Hydroxyl significantly improves the corrosion resistance while polydopamine and hyaluronic acid layers act as a further barrier to provide better anticorrosion. A balance between biocompatibility and antithrombogenicity has been achieved by adjusting the content of hyaluronic acid on polydopamine surface. The multifunctional magnesium/OH/polydopamine/hyaluronic acid coating with lower hyaluronic acid concentrations expose more active sites of polydopamine molecules to promote endothelial cell proliferation while retaining the intrinsic antithrombogenic function of hyaluronic acid to offer a potential application for vascular stents.

show abstract

“…To improve the corrosion resistance of Mg alloys, surface modification has become the research focus of medical Mg alloys [7]. Chemical conversion coatings [8,9], electrochemical coatings [10,11], polymer coatings [12,13], ceramic coatings [14,15], ion implantation coatings [16,17], composite coatings [18,19] etc. improve the corrosion performance of Mg alloys.…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal Synthesis of Protective Coating on Mg Alloy for Degradable Implant Applications

et al. 2019

View full text Add to dashboard Cite

Biodegradable magnesium (Mg) alloys are known as "the new generation of biomedical metal materials". However, high degradation rates restrict their clinical application. To overcome this issue, a new and simple method for producing of protective coating based on hydrothermal synthesis at 200 °C in 0.5 M NaHCO3 was elaborated. The microstructure, elemental and phase composition of the produced films were examined by scanning electron microscope (SEM), X-ray energy-dispersive spectrometer (EDS) and X-ray diffraction (XRD). The mechanical strength of the protective coating was evaluated by grid scribing method. The corrosion protection effect was evaluated using linear sweep voltammogram (LSV) and electrochemical impedance spectroscopy (EIS) methods in the simulated body fluid (SBF). Since the corrosion process is accompanied by stoichiometric evolution of hydrogen, the amount of the latter was measured to quantify the overall corrosion rate. Both the coatings morphology and phase composition were sensitive to the treatment duration. The coating formed after 0.5 h was loose and mainly consisted of spherical flower-like Mg5(CO3)4(OH)2·4H2O accompanied by small amounts of Mg(OH)2. The treatment duration of 3 h resulted in a thicker compact coating composed mainly of irregular granular MgCO3 as well as Mg(OH)2. The coating providing the most effective protection and uniform corrosion was achieved by 2 h treatment at 200 °C.

show abstract

Enhanced Anti-corrosion Ability and Biocompatibility of PLGA Coatings on MgZnYNd Alloy by BTSE-APTES Pre-treatment for Cardiovascular Stent

Cited by 47 publications

References 73 publications

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Layered hydroxide/polydopamine/hyaluronic acid functionalized magnesium alloys for enhanced anticorrosion, biocompatibility and antithrombogenicity in vascular stents

Hydrothermal Synthesis of Protective Coating on Mg Alloy for Degradable Implant Applications

Contact Info

Product

Resources

About