“…The pathogenesis of microalbuminuria is multifactorial and hyperglycaemia [3], glomerular hyperfiltration [4], nitric oxide [5], angiotensin II [6], kinins [7], prostaglandins [8] and transforming growth factor-B [9] have all been shown to influence the rate of urinary albumin excretion. It has been hypothesised that ANP contributes to the development of microalbuminuria in type-1 diabetes, on the basis of human [10][11][12] and animal data [13], which has shown that ANP increases urine albumin excretion. However, the role of ANP in the development of microalbuminuria in type-2 diabetes is less well understood.…”