Elevated plasma concentrations of atrial and brain natriuretic peptide in type 1 diabetic subjects

McKenna, Kenneth Z.; Smith, Diarmuid; Sherlock, Mark; Moore, KB; O’Brien, E; Tormey, William; Thompson, CJ

doi:10.1007/bf03169149

Cited by 16 publications

(6 citation statements)

References 22 publications

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“…In another study with type 1 DM, glucose infusion caused elevation of ANP, but not BNP levels. They also showed in another study that plasma concentrations of ANP and BNP were elevated in patients with type 1 DM [14,15]. Similarly to our study, they also found that plasma BNP concentrations were related to HbA1c.…”

Section: Discussionsupporting

confidence: 90%

The relationship between glycemic control and BNP levels in diabetic patients

Dal¹,

Ata

Yavuz

et al. 2014

Cardiol J

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Section: Discussionsupporting

confidence: 90%

The relationship between glycemic control and BNP levels in diabetic patients

Dal¹,

Ata

Yavuz

et al. 2014

Cardiol J

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“…They found a close relationship between plasma ANP level and acute or chronic hyperglycemia. In that study, they showed that ANP concentrations in type 1 diabetic patients (especially with chronic poor glycemic control) were high in subgroups with systemic hypertension and microalbuminuria [9]. In another study evaluating the relationship between ANP levels and nephropathy, natriuretic peptide levels of type 2 diabetic rats were significantly higher than nondiabetic rats [10].…”

Section: Discussionmentioning

confidence: 93%

“…Jacobs et al [8] claimed that the excess increase in urinary protein excretion -during 1-hour ANP infusion to type 1 diabetic patients with microalbuminuria -was not only related with glomerular pressure changes but also with the decrease of tubular protein reabsorption. In another study, McKenna et al [9] investigated the physiopathological markers of the albuminuric effects of increased ANP concentrations in type 1 diabetic patients. They found a close relationship between plasma ANP level and acute or chronic hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

The relationship between atrial natriuretic peptide and microvascular complications of diabetes

Karakaya

Özdemir

Mert

et al. 2019

The European Research Journal

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Objectives: In this study, we aimed to determine the relationship between the atrial natriuretic peptide and microvascular complications of diabetes. Methods: Sixty patients with type 2 diabetes mellitus were enrolled into the study. Patients with a chronic disease other than diabetes mellitus were excluded from the study. The body-mass index, waist circumference, and hip circumference were measured and blood samples for routine biochemical tests were taken after at least 12 hours fasting. The microvascular complications of the patients were evaluated. Results: Thirty-two of the patients had microvascular complications whereas 28 of them did not. Age, body mass index, waist and hip circumference, and atrial natriuretic peptide levels were significantly higher in the group with microvascular complications than those without complications. There was no significant difference in parameters like; waist-hip ratio, blood glucose, HbA1c, fasting insulin, fasting HOMA, sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between atrial natriuretic peptide and obesity, retinopathy, neuropathy, nephropathy, duration of diabetes, HbA1c, and sex are evaluated separately, the only significant parameters related to atrial natriuretic peptide were the body-mass index, waist circumference, hip circumference measurements, and neuropathy. Conclusions: Positive correlations between serum atrial natriuretic peptide levels and body-mass index, waist circumference, and hip circumference measurements were determined. Also, serum atrial natriuretic peptide levels were significantly higher in patients with obesity or neuropathy than those without obesity or neuropathy.

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“…Outside of pregnancy, DM1 [ 38 , 39 ] and DM2 [ 40 ] are associated with elevated NT-proBNP levels. Moreover, NT-proBNP may act as an independent risk factor for CVD in patients with DM1 [ 41 ] and DM2 [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular biomarkers in pregnancy with diabetes and associations to glucose control

et al. 2022

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Aim Cardiovascular disease (CVD) is a leading cause of death in both men and women. Type 1 and 2 diabetes mellitus (DM1 and DM2) are well-known risk factors for CVD. In addition, gestational diabetes mellitus (GDM) is a female sex-specific risk factor for CVD. Here, we measure circulating concentrations of cardiac troponin T (cTNT), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and growth differentiation factor 15 (GDF-15) during pregnancy—a window of time often referred to as a cardiovascular stress test for women. Methods This study utilized data from 384 pregnant women: 64 with DM1, 16 with DM2, 35 with GDM and 269 euglycemic controls. Blood was predominantly sampled within a week before delivery. Cardiovascular biomarker concentrations were measured in serum using electrochemiluminescence immunoassay. Result Circulating cTnT levels were higher in women with DM1, DM2 and GDM as compared to controls, whereas NT-proBNP and GDF-15 levels were only increased in women with DM1. Glucose dysregulation, assessed by third trimester HbA1c levels, positively correlated with all three CVD biomarker levels, whereas pregestational body mass index correlated negatively with GDF-15. Conclusions Our results support the presence of myocardial affection in women with diabetic disorders during pregnancy. Although pregestational DM1 in this study was associated with the most adverse CVD biomarker profile, women with GDM displayed an adverse cTnT profile similar to what we found in women with pregestational DM2. This supports that women with GDM should be offered long-term intensified cardiovascular follow-up and lifestyle advice following delivery, similarly to the well-established CV follow-up of women with pregestational DM.

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Elevated plasma concentrations of atrial and brain natriuretic peptide in type 1 diabetic subjects

Cited by 16 publications

References 22 publications

The relationship between glycemic control and BNP levels in diabetic patients

The relationship between glycemic control and BNP levels in diabetic patients

The relationship between atrial natriuretic peptide and microvascular complications of diabetes

Cardiovascular biomarkers in pregnancy with diabetes and associations to glucose control

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