Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine

Abstract

Biomaterials intentionally designed to support the expansion, differentiation, and three-dimensional (3D) culture of induced-pluripotent stem cells (iPSCs) may pave the way to cell-based therapies for chronic respiratory diseases. These conditions are endured by millions of people worldwide and represent a significant cause of morbidity and mortality. Currently, there are no effective treatments for the majority of advanced lung diseases and lung transplantation remains the only hope for many chronically ill patients. Key opinion leaders speculate that the novel coronavirus, COVID-19, may lead to long-term lung damage, further exacerbating the need for regenerative therapies. New strategies for regenerative cell-based therapies harness the differentiation capability of human iPSCs for studying pulmonary disease pathogenesis and treatment. Excitingly, biomaterials are a cell culture platform that can be precisely designed to direct stem cell differentiation. Here, we present a closer look at the state-of-the-art of iPSC differentiation for pulmonary engineering, offer evidence supporting the power of biomaterials to improve stem cell differentiation, and discuss our perspective on the potential for tissue-informed biomaterials to transform pulmonary regenerative medicine.

3D Bioprinting for Tissue Engineering Amidst the Century Cataclysm

“…As long as the interaction between cells and scaffold systems with biomolecules can be understood and controlled and on the understanding that an optimal 3D environment for tissue regeneration can be realized, 3D Nano printing will become an important tool in tissue engineering in the near future. My opinions harmonized with Campbell, et al, that crucial standpoint commanders suppose that the new COVID-19 may drive to prolonged lung harm, furthermore triggering the requirement for regenerative therapies [8]. Modern strategies for regenerative cell-based treatments use the segregation ability of human MSCs for searching lung disease pathogenesis and therapy [9,10].…”

“…Interestingly, biomaterials are a cell culture stage that can be exactly layout to guide stem cell discrimination [11,12]. Also, Campbell and colleagues reported that the COVID-19 pandemic has supplied clinical facts displaying fibrosis of lung in these patients that remain alive after the contagion [8]. It is speculated that this fibrotic reaction will not retract, leading to a concealed flourishing of chronic pulmonary disease later on.…”

Construction of Microfluidic Chip Structure for Cell Migration Studies in Bioactive Ceramics

“…[4,5] Expanded tissue induction with regenerative medicine extended the boundaries of the repair concept in clinical practice. [6,7] The introduction of technologies represented by 3D printing technology created conditions for solving difficult problems such as complex/composite materials, the synergy of multiple tissues and organs, and personalized repair of specific parts. [8,9] The application of bioactive ceramics in bone tissue repair is increasing, and the introduction of new technologies/methods has generated various innovative devices.…”