Engineering rice based medium for production of lovastatin with Monascus species

Panda, Bibhu Prasad; Javed, Saleem; Ali, Mohamed

doi:10.17221/47/2008-cjfs

Cited by 10 publications

(11 citation statements)

References 26 publications

(41 reference statements)

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“…RSM has some advantages that include fewer experiment numbers, suitability for multiple factor experiments, search for relativity between factors, and finding of the most suitable condition and forecast response (Popa et al, 2007;Panda et al, 2009). This facilitates the determination of optimum values of the factors under investigation and prediction of response under optimized conditions (Panda et al, 2009;Chakravarti and Sahai, 2002).…”

Section: Resultsmentioning

confidence: 99%

Gibberellic acid, amino acids (glycine and L-leucine), vitamin B2 and zinc as factors affecting the production pigments by Monascus purpureus in a liquid culture using response surface methodology

Baneshi¹,

Azizi²,

Saberi³

et al. 2014

Afr. J. Biotechnol.

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The combined effects of zinc, gibberellic acid, vitamin B 2 , amino acids (glycine and L-leucine) on pigment production were evaluated in a liquid culture of Monascus purpureus. In this study, response surface design was used to optimize each parameter. The data were analyzed using Minitab 14 software. Five parameters were applied by using response surface methodology for pigment production in liquid cultures. Four zinc, 11 gibberellic acids, three vitamins B 2 , eleven and fifteen amino acids (glycine and L-leucine) respectively; levels were evaluated. The highest production of pigment was reached with a 10 mg/l vitamin B 2 , 50 mg/l gibberellic acid and 50 mg/l glycine amino acid.

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Section: Resultsmentioning

confidence: 99%

Gibberellic acid, amino acids (glycine and L-leucine), vitamin B2 and zinc as factors affecting the production pigments by Monascus purpureus in a liquid culture using response surface methodology

Baneshi¹,

Azizi²,

Saberi³

et al. 2014

Afr. J. Biotechnol.

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show abstract

“…Glucose is said to exert repressive action but a combination of glucose, glycerol and peptone in medium is best for M pilosus to produce lovastatin. Dextrose, KH 2 PO 4 and FeSO 4 do not aid in much lovastatin production when compared to NH 4 Cl, MgSO 4 and NaCl when present in medium inoculated with M purpureus 369 [27]. Various physiconutritional parameters that govern lovastatin production have been well documented [5].…”

Section: Solid Substrate Fermentation For Lovastatin Productionmentioning

confidence: 99%

Solid State Fermentation: An Effective Method for Lovastatin Production by Fungi – A Mini Review

Praveen¹

2012

TOTMJ

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Lovastatin, an anti-cholesterol drug, is a potent inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG CoA reductase) that catalyses conversion of HMG CoA to mevalonate involved in cholesterol biosynthesis. Lovastatin does not only find a role as anti-cholesterol agent but also plays a key role as an anti-inflammatory agent, cancer cell apoptosis, renal function restoration, treatment for bone disorders etc. Production of statins has been undertaken by Submerged Fermentation (SmF) and Solid State Fermentation (SSF) by using fungi. In view of the advantages of SSF over SmF, the focus has shifted to production by SSF in recent years. The use of various agro based wastes as substrates has been proven. With recent developments in molecular biology and genome studies it has been able to decode genetic aspects of lovastatin gene expression levels. This review gives an insight into works reported on lovastatin production by SSF, various substrates employed, mutation studies, optimisation parameters, molecular studies and medical application of lovastatin.

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“…The fungi are also useful in medicine production because of its monacolin K (lovastatin) compound that capable for lowering blood cholesterol (Panda et al, 2009). But, some researchers showed citrinin as a toxin compound producing by Monascus.…”

Section: Introductionmentioning

confidence: 99%

Pigment Production of Monascus sp. Isolated from Angkak in Semarang Region, Central Java, Indonesia

Kusdiyantini

Nugraha

Lunggani

2017

IFNP

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Angkak (red fungi rice, red yeast rice) is a traditional fermentation by fungi Monascus in a lot of Asia Countries, which is useful as a natural food colorant. The aim of this research was to obtain pure isolate of red fungus from angkak in Semarang. The growth and the red pigment production of the selected isolate in the different initial medium pH and nitrogen sources were observed. The treatment was done by growing the isolate in PDB (Potato Dextrose Broth) medium at initial pH 3, 5, 7 and 9 and as well as optimization of nitrogen sources with 1% ammonium chloride, 1% ammonium nitrate, and 1% peptone. The results showed that the highest absorbance value of pigment (0.81) was obtained at pH 7, and the highest value of the cell dry weight was also obtained at pH 7 (1.23 g/L). The results showed that 1% ammonium chloride was the best nitrogen source for red pigment production which gives the highest absorbance (0.82) and the highest of dry weight (2.56 g/L) was obtained by using medium with 1% ammonium nitrate as a nitrogen source.

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Engineering rice based medium for production of lovastatin with Monascus species

Cited by 10 publications

References 26 publications

Gibberellic acid, amino acids (glycine and L-leucine), vitamin B2 and zinc as factors affecting the production pigments by Monascus purpureus in a liquid culture using response surface methodology

Gibberellic acid, amino acids (glycine and L-leucine), vitamin B2 and zinc as factors affecting the production pigments by Monascus purpureus in a liquid culture using response surface methodology

Solid State Fermentation: An Effective Method for Lovastatin Production by Fungi – A Mini Review

Pigment Production of Monascus sp. Isolated from Angkak in Semarang Region, Central Java, Indonesia

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