Engineering of a dual-modal phototherapeutic nanoplatform for single NIR laser-triggered tumor therapy

Zhang, Mengzhu; Qin, Xiaohan; Xu, Wei; Wang, Yibing; Song, Yunmei; Garg, Sanjay; Luan, Yuxia

doi:10.1016/j.jcis.2021.03.050

Cited by 106 publications

(42 citation statements)

References 55 publications

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“…Moreover, high cost and the existence of immune-related adverse reactions (IrAEs) further limit its application [ 4 ]. PTT is widely used for cancer treatment because of its noninvasiveness, low energy consumption, and minimal toxicity to normal tissues [ 72 , 73 ]. However, limited light penetration depth may lead to incomplete tumor ablation can cause tumor recurrence or even metastasis.…”

Section: Resultsmentioning

confidence: 99%

Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer

Chen

Zhang

et al. 2021

J Nanobiotechnol

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Background Mono-therapeutic modality has limitations in combating metastatic lesions with complications. Although emerging immunotherapy exhibits preliminary success, solid tumors are usually immunosuppressive, leading to ineffective antitumor immune responses and immunotherapeutic resistance. The rational combination of several therapeutic modalities may potentially become a new therapeutic strategy to effectively combat cancer. Results Poly lactic-co-glycolic acid (PLGA, 50 mg) nanospheres were constructed with photothermal transduction agents (PTAs)-Prussian blue (PB, 2.98 mg) encapsulated in the core and chemotherapeutic docetaxel (DTX, 4.18 mg)/ immune adjuvant-imiquimod (R837, 1.57 mg) loaded in the shell. Tumor cell membranes were further coated outside PLGA nanospheres (designated “M@P-PDR”), which acted as “Nano-targeted cells” to actively accumulate in tumor sites, and were guided/monitored by photoacoustic (PA)/ magnetic resonance (MR) imaging. Upon laser irradiation, photothermal effects were triggered. Combined with DTX, PTT induced in situ tumor eradication. Assisted by the immune adjuvant R837, the maturation rate of DCs increased by 4.34-fold compared with that of the control. In addition, DTX polarized M2-phenotype tumor-associated macrophages (TAMs) to M1-phenotype, relieving the immunosuppressive TME. The proportion of M2-TAMs decreased from 68.57% to 32.80%, and the proportion of M1-TAMs increased from 37.02% to 70.81%. Integrating the above processes, the infiltration of cytotoxic T lymphocytes (CTLs) increased from 17.33% (control) to 35.5%. Primary tumors and metastasis were significantly inhibited when treated with “Nano-targeted cells”-based cocktail therapy. Conclusion “Nano-targeted cells”-based therapeutic cocktail therapy is a promising approach to promote tumor regression and counter metastasis/recurrence. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer

Chen

Zhang

et al. 2021

J Nanobiotechnol

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“…Photothermal therapy (PTT), as well as photodynamic therapy (PDT), is a noninvasive treatment strategy based on special materials in response to special wavelength light, which has been widely applied in the cancer diagnosis and treatment (Li et al., 2017a ; Zhang et al., 2021 ). Recently, it could enhance antitumor efficiency when chemotherapy is combined with PTT or PDT through nanotechnology, which not only achieves the antitumor drugs targeting releasing but also integrates the PTT or PDT tumor kills.…”

Section: Phototherapymentioning

confidence: 99%

Recent advances in anti-multidrug resistance for nano-drug delivery system

Wang

Zhang

et al. 2022

Drug Delivery

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Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS) has been explored to sensitize the anticancer drugs and decrease its side effects, which are applied in combating multidrug resistance (MDR) via a variety of mechanisms including bypassing drug efflux, controlling drug release, and disturbing metabolism. This review starts with a brief report on the major MDR causes. Furthermore, we searched the papers from NDDS and introduced the recent advances in sensitizing the chemotherapeutic drugs against MDR tumors. Finally, we concluded that the NDDS was based on several mechanisms, and we looked forward to the future in this field.

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“…The lack of selectivity of common anti-cancer drugs lead to their most common side effects including; hair loss, vomiting, fatigue and the risk of developing various infections [2] . In addition, multi drug resistance is a main complication to effective chemotherapy, where cancer cells develop resistance against cytotoxic drugs during or shortly after commencement of therapy [3] . All these demerits associated with chemotherapeutics extremely limit the development of new anticancer drugs [4] .…”

Section: Introductionmentioning

confidence: 99%

Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

Hasanin¹,

Taha²,

Abdou³

et al. 2022

Biotechnology Reports

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Engineering of a dual-modal phototherapeutic nanoplatform for single NIR laser-triggered tumor therapy

Cited by 106 publications

References 55 publications

Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer

Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer

Recent advances in anti-multidrug resistance for nano-drug delivery system

Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

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