Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

Hasanin, Mohamed S.; Taha, Nesrin F.; Abdou, Aya R.; Emara, Laila H.

doi:10.1016/j.btre.2022.e00722

Cited by 29 publications

(11 citation statements)

References 72 publications

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“…The GA and Ch execute a polysaccharide behavior which consists of simple, repetitive sequences prefer to adopt helical conformations 38 . Consequently, GA exhibits an amorphous spectrum with two intense diffraction peaks at 2 θ = 8° and 18.8° which are signed to the amorphous structure of gum Arabic 39 , 40 . Ch spectrum approves two hubs at intensities around 2 θ of 11° and 21° referred to the conventional XRD pattern of the pristine chitosan 41 .…”

Section: Resultsmentioning

confidence: 99%

Green and sustainable chitosan–gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media

Kiey

Hasanin²,

Heakal³

2022

Sci Rep

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The application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments. Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods. The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques. All methods yielded consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate. The obtained protection efficiency was enhanced with increasing CGAC dose in the applied surface layer achieving 96.6% for the 200 ppm-coating. SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl- ions from attacking the metallic substrate. The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one. The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.

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Section: Resultsmentioning

confidence: 99%

Green and sustainable chitosan–gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media

Kiey

Hasanin²,

Heakal³

2022

Sci Rep

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“…The fixed weight (100 mg) of tablets was directly compressed using 6.35 mm flat punches. The compression force was set at 4N for minimizing the effect of physical parameters on drug dissolution. , …”

Section: Tablet Preparationmentioning

confidence: 99%

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Mishra

2024

ACS Omega

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Nanocrystalline cellulose (CNC) has emerged as a subject of researcher’s interest because of its diverse attributes encompassing biocompatibility, sustainability, a high aspect ratio, and an abundance of −OH groups suitable for modifications. Sugarcane bagasse microcrystalline cellulose (SCBMCC) was used as the raw material for the preparation of CNC due to its pure cellulose content, which is mildly compromised by the pectin, hemicellulose, lignin, and other lignocellulosic components. In the present work, CNC was extracted from SCBMCC and used as a disintegrant. The classic hydrolysis technique was used for the preparation of CNC. Hydrolytic conditions were optimized using the response surface methodology (RSM). The optimized batch of CNC was characterized using techniques such as field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Notably, CNC prepared under a hydrolysis time of 90 min exhibited the highest crystallinity of 69.9%. The average particle size and zeta potential were found to be 145 nm and −34.4 mV, respectively. Thermal analysis suggested that an intermediate hydrolysis time resulted in CNC with enhanced thermal stability, showcasing its potential for pharmaceutical applications. Diclofenac potassium was used as the model drug to evaluate the disintegrant properties of CNC as an excipient. Tablets were prepared using the direct compression method. SCBMCC and CNC were used as disintegrants and were compared with the commercial product. The disintegration times (DTs) attained for the tablets prepared using CNC and SCBMCC are 219 and 339.83 s, respectively. The dissolution study of CNC showed a dissolution efficacy (DE%) of 66 and a mean dissolution time (MDT) of 12. The research findings showed that tablets prepared using CNC as disintegrants exhibited the fastest disintegration compared to other formulations.

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“…It can also enhance the process of drug uptake by cancer cells. Similarly, gelatin can also be used to enhance the stability of graphene materials in vivo through hydrophobic interactions on the graphene surface ( Hasanin et al, 2022 ).…”

Section: Properties Of Gelatin For An Anticancer Ddnsmentioning

confidence: 99%

Gelatin-based anticancer drug delivery nanosystems: A mini review

Jiang

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Drug delivery nanosystems (DDnS) is widely developed recently. Gelatin is a high-potential biomaterial originated from natural resources for anticancer DDnS, which can effectively improve the utilization of anticancer drugs and reduce side effects. The hydrophilic, amphoteric behavior and sol-gel transition of gelatin can be used to fulfill various requirements of anticancer DDnS. Additionally, the high number of multifunctional groups on the surface of gelatin provides the possibility of crosslinking and further modifications. In this review, we focus on the properties of gelatin and briefly elaborate the correlation between the properties and anticancer DDnS. Furthermore, we discuss the applications of gelatin-based DDnS in various cancer treatments. Overall, we have summarized the excellent properties of gelatin and correlated with DDnS to provide a manual for the design of gelatin-based materials for DDnS.

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Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

Cited by 29 publications

References 72 publications

Green and sustainable chitosan–gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media

Green and sustainable chitosan–gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Gelatin-based anticancer drug delivery nanosystems: A mini review

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