Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

“…Tissue repair aims to develop biological substitutes for the repair or improvement of defective tissues, organ structures, etc. 172,173 Therefore, the materials used are required to be highly biocompatible and non-immunogenic, and when used in the body, also require the material to be effective in a wet environment. [174][175][176] Due to their good mechanical properties, biocompatibility, and tissue affinity, 177 adhesive materials can play an important role in various aspects of tissue repair.…”

Precision medicine strategies for spinal degenerative diseases: Injectable biomaterials with in situ repair and regeneration

“…As the concept of minimally invasive surgery is widely accepted in the clinic, injectable biomaterials have been widely used [ 17 ]: 1) Minimally invasive surgery, which can be injected into the lesion site; 2) In-situ curing to fill irregular areas in the body; 3) Carrier function, which can carry cells, drugs, genes, factors, etc. Currently, the injectable biomaterials commonly used in clinical and experimental studies for spinal system diseases are primarily divided into hydrogel materials (natural and synthetic hydrogel), bone cement materials (including acrylate, calcium phosphate, calcium sulphate, bioactive glass and calcium silicate) and other injectable materials.…”

Multiple Coordination‐Derived Bioactive Hydrogel with Proangiogenic Hemostatic Capacity for Wound Repair

“…[ 29,30 ] Recently, citric acid‐containing polymers have been proverbially investigated for the application in tissue regeneration because of their biomimetic elastomeric mechanical properties, good biocompatibility, degradability, and biological activities including anti‐inflammation and angiogenesis. [ 31–33 ] In previous studies, our group has prepared poly (citrate‐ethylene glycol) (PCG)‐containing hybrid polymers and further confirmed their potential applications in gene delivery, wound repair, tumor therapy, and bone regeneration. [ 34–36 ]…”

“…[1,2] proverbially investigated for the application in tissue regeneration because of their biomimetic elastomeric mechanical properties, good biocompatibility, degradability, and biological activities including anti-inflammation and angiogenesis. [31][32][33] In previous studies, our group has prepared poly (citrate-ethylene glycol) (PCG)-containing hybrid polymers and further confirmed their potential applications in gene delivery, wound repair, tumor therapy, and bone regeneration. [34][35][36] In this study, based on the good metal coordination capacity of SA and AL, the good bioactivity of PCG polymer as well as the multiple coordination of trivalent rare earth metal ions, we report a novel reversible dynamic multifunctional bioactive hydrogel with tailored anti-inflammation angiogenic activity for rapid hemostasis and wound repair (Figure 1).…”