Engineering in-plane mechanics of electrospun polyurethane scaffolds for cardiovascular tissue applications

Luketich, Samuel K.; Cosentino, F; Giuseppe, Marzio Di; Menallo, Giorgio; Nasello, Gabriele; Livreri, Patrizia; Wagner, William R.; D’Amore, Antonio

doi:10.1016/j.jmbbm.2022.105126

Cited by 9 publications

(4 citation statements)

References 75 publications

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“…Given their excellent flexibility, wear resistance, and easy formability, PUs meet the tensile strength and elastic modulus requirements for the fluid environments of applications in the cardiovascular system. 43 , 44 Thus, they are used to prepare prostheses such as artificial blood vessels and heart valves by electrostatic spinning and three-dimensional printing. 45 However, PU exhibits hydrolytic degradation and thrombogenicity when in contact with blood components, such as platelets and cholesterol esterase.…”

Section: Advantages and Potential Application Of Nano-modified Medica...mentioning

confidence: 99%

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

Wang

Dai

Xie

et al. 2022

IJN

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Polyurethane (PU) has wide application and popularity as medical apparatus due to its unique structural properties relationship. However, there are still some problems with medical PUs, such as a lack of functionality, insufficient long-term implantation safety, undesired stability, etc. With the rapid development of nanotechnology, the nanomodification of medical PU provides new solutions to these clinical problems. The introduction of nanomaterials could optimize the biocompatibility, antibacterial effect, mechanical strength, and degradation of PUs via blending or surface modification, therefore expanding the application range of medical PUs. This review summarizes the current applications of nano-modified medical PUs in diverse fields. Furthermore, the underlying mechanisms in efficiency optimization are analyzed in terms of the enhanced biological and mechanical properties critical for medical use. We also conclude the preparation schemes and related parameters of nano-modified medical PUs, with discussions about the limitations and prospects. This review indicates the current status of nano-modified medical PUs and contributes to inspiring novel and appropriate designing of PUs for desired clinical requirements.

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Section: Advantages and Potential Application Of Nano-modified Medica...mentioning

confidence: 99%

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

Wang

Dai

Xie

et al. 2022

IJN

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“…Cardiac tissue engineering is a promising strategy to create implantable cardiac patches with both the structural and functional mechanical properties of native myocardium 5,9,10,15–17 . Current strategies to promote active regeneration of damaged myocardium use scaffolds composed of natural materials, 13–15,18–20 synthetic materials, 11,21–23 extracellular matrix, 13,24–26 decellularized tissues, 27,28 composite materials 11,17,29–31 engineered tissues that integrate the promising functions of biomaterials and stem cell therapies, such as iPS‐CMs, 6,7,11,12,32 as well as modular scaffolds that integrate myocardial components of the tissue into scalable units 33–35 to guide myocardial regeneration. While various studies have shown that engineered scaffolds are capable of contraction, 11,12,14,20,36 and of providing some increase in mechanical function to the injured heart, 11,12,14,20,24 there remains a significant need to develop a functional, engineered cardiac patch that easily integrates with the surrounding tissue to promote the regeneration of myocardial tissue with physiologically relevant contractility 5,9,10,13,15 .…”

Section: Introductionmentioning

confidence: 99%

“…3,5,[9][10][11][12][13][14][15][16] Cardiac tissue engineering is a promising strategy to create implantable cardiac patches with both the structural and functional mechanical properties of native myocardium. 5,9,10,[15][16][17] Current strategies to promote active regeneration of damaged myocardium use scaffolds composed of natural materials, [13][14][15][18][19][20] synthetic materials, 11,[21][22][23] extracellular matrix, 13,[24][25][26] decellularized tissues, 27,28 composite materials 11,17,[29][30][31] engineered tissues that integrate the promising functions of biomaterials and stem cell therapies, such as iPS-CMs, 6,7,11,12,32 as well as modular scaffolds that integrate myocardial components of the tissue into scalable units [33][34][35] to guide myocardial regeneration. While various studies have shown that engineered scaffolds are capable of c...…”

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confidence: 99%

Micropatterned fibrin scaffolds increase cardiomyocyte alignment and contractility for the fabrication of engineered myocardial tissue

English

Samolyk

Gaudette

et al. 2023

J Biomedical Materials Res

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Cardiovascular disease is the leading cause of death in the United States, which can result in blockage of a coronary artery, triggering a myocardial infarction (MI), scar tissue formation in the myocardium, and ultimately heart failure. Currently, the goldstandard solution for total heart failure is a heart transplantation. An alternative to total-organ transplantation is surgically remodeling the ventricle with the implantation of a cardiac patch. Acellular cardiac patches have previously been investigated using synthetic or decellularized native materials to improve cardiac function. However, a limitation of this strategy is that acellular cardiac patches only reshape the ventricle and do not increase cardiac contractile function. Toward the development of a cardiac patch, our laboratory previously developed a cell-populated composite fibrin scaffold and aligned microthreads to recapitulate the mechanical properties of native myocardium. In this study, we explore micropatterning the surfaces of fibrin gels to mimic anisotropic native tissue architecture and promote cellular alignment of human induced pluripotent stem cell cardiomyocytes (hiPS-CM), which is crucial for increasing scaffold contractile properties. hiPS-CMs seeded on micropatterned surfaces exhibit cellular elongation, distinct sarcomere alignment, and circumferential connexin-43 staining at 14 days of culture, which are necessary for mature contractile properties. Constructs were also subject to electrical stimulation during culture to promote increased contractile properties. After 7 days of stimulation, contractile strains of micropatterned constructs were significantly higher than unpatterned controls. These results suggest that the use of micropatterned topographic cues on fibrin scaffolds may be a promising strategy for creating engineered cardiac tissue.

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“…Nanofiber scaffolds produced by the electrospinning technique have been used in all fields of tissue engineering, to name a few, bone, cardiovascular, ligament and skin tissue engineering [ 11 , 12 , 13 ]. Aligned nanofibers produced by this technique are highly favorable for the growth of osteocytes.…”

Section: Introductionmentioning

confidence: 99%

Evolution of Electrospinning in Liver Tissue Engineering

et al. 2022

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The major goal of liver tissue engineering is to reproduce the phenotype and functions of liver cells, especially primary hepatocytes ex vivo. Several strategies have been explored in the recent past for culturing the liver cells in the most apt environment using biological scaffolds supporting hepatocyte growth and differentiation. Nanofibrous scaffolds have been widely used in the field of tissue engineering for their increased surface-to-volume ratio and increased porosity, and their close resemblance with the native tissue extracellular matrix (ECM) environment. Electrospinning is one of the most preferred techniques to produce nanofiber scaffolds. In the current review, we have discussed the various technical aspects of electrospinning that have been employed for scaffold development for different types of liver cells. We have highlighted the use of synthetic and natural electrospun polymers along with liver ECM in the fabrication of these scaffolds. We have also described novel strategies that include modifications, such as galactosylation, matrix protein incorporation, etc., in the electrospun scaffolds that have evolved to support the long-term growth and viability of the primary hepatocytes.

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Engineering in-plane mechanics of electrospun polyurethane scaffolds for cardiovascular tissue applications

Cited by 9 publications

References 75 publications

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

Micropatterned fibrin scaffolds increase cardiomyocyte alignment and contractility for the fabrication of engineered myocardial tissue

Evolution of Electrospinning in Liver Tissue Engineering

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