Engineering functional inorganic nanobiomaterials: controlling interactions between 2D-nanosheets and enzymes

Puglia, Megan K.; Malhotra, Mansi

doi:10.1039/c9dt03893k

Cited by 7 publications

(6 citation statements)

References 69 publications

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“…10,11 Compared to single-layered nanosheets, double-layered nanosheets are attractive for their use as nanocarriers and nanocontainers because of the robust retention of molecules or organic ions in their interlayers. 12,13 On the other hand, their sandwich structures could be a disadvantage upon releasing and exposing the molecules retained in the interlayer. 14 A dynamic change from double- to single-layered structures is therefore desired for applications of double-layered nanosheets.…”

Section: Introductionmentioning

confidence: 99%

Preparation of double-layered nanosheets containing pH-responsive polymer networks in the interlayers and their conversion into single-layered nanosheets through the cleavage of cross-linking points

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Preparation of double-layered nanosheets containing pH-responsive polymer networks in the interlayers and their conversion into single-layered nanosheets through the cleavage of cross-linking points

et al. 2022

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“…The surface biofunctionalized α-ZrP serves as a glue for the binding of various enzymes such as pepsin, GO, lysozyme, catalase, myoglobin, and laccase. 207,208 The loading of the enzyme increased linearly with the number of residues and also the bound enzyme retained their secondary structure and hence biological activity (>90%). Such studies are useful to engineer the biocatalysts with α-ZrP as a robust support material.…”

Section: Surface Functionalization Of Zrpmentioning

confidence: 99%

“…Apart from functionalization with silanes, chlorosilanes, epoxides, and isocyanate, the surface of ZrP was modified by depositing metal ions on its surface by an ion exchange process. ,− Depositing a variety of metal cations exclusively on the surface of ZrP allows researchers to demonstrate the success in formulating layer-by-layer assemblies with ZrP as a functional support material. Clearfield et al published an article in 2014 and reported in their work the ability to build an LBL assembly on ZrP nanoparticles .…”

Section: Surface Functionalization Of Zrpmentioning

confidence: 99%

“…However, only Zr(IV) and Ca(II) display enhanced and satisfactory metal-mediated GO binding. Within the principles of the ion coupled protein binding model, deposition of Zr(IV) ions display a 380 fold increase in binding constant for GO due to the strong oxophyllic/phosphophyllic character of Zr(IV) ions, thereby readily coordinating with the carboxyl groups present in GO. − The same research group investigated biofunctionalization of exfoliated α-ZrP nanosheets with cationized bovine serum albumin (cBSA). The surface biofunctionalized α-ZrP serves as a glue for the binding of various enzymes such as pepsin, GO, lysozyme, catalase, myoglobin, and laccase. , The loading of the enzyme increased linearly with the number of residues and also the bound enzyme retained their secondary structure and hence biological activity (>90%).…”

Section: Surface Functionalization Of Zrpmentioning

confidence: 99%

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Revisiting the Old and Golden Inorganic Material, Zirconium Phosphate: Synthesis, Intercalation, Surface Functionalization, and Metal Ion Uptake

Bashir

Ahad

Malik

et al. 2020

Ind. Eng. Chem. Res.

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As a fascinating two-dimensional (2D) layered inorganic ion exchange material, zirconium phosphate (hereafter ZrP) has drawn interdisciplinary attention as an ion exchange material and a competent host for surface functionalization and intercalation. This is due to its captivating properties such as simple synthesis procedure, excellent ion-exchange capacity, excellent chemical, thermal, and radiolytic stability, tunable interlayer gallery, and good biocompatibility. Among all the well-known phases of ZrP, we restrict our discussion only to the alpha (α-ZrP) and gamma (γ-ZrP) phases for their efficient ion exchange performance and more tunable interlayer spacing. This review summarizes a panorama of the recent research progress on the synthesis, intercalation, and surface functionalization of ZrP with organic molecules, metal complexes, and metal ions for the design and fabrication of self-assembled monolayers, layer-by-layer assemblies, and nanocomposites. Within the confined gallery microenvironment of ZrP, usual molecules behave unusually with dramatic enhancement in the photophysical properties. The intercalation of metal complexes and their fascinating electronic properties will also be comprehensively highlighted in this review. Furthermore, for the first time, a cutting-edge advancement (2010 onward) of the versatile adsorption performance of ZrP-based materials for the uptake of toxic metal ions which include nuclear waste-related metal ions, heavy metal ions, and rare earth ions will be presented in detail. Last but not least, the review will conclude with the summary and future directions, which will provide new research opportunities for the development of ZrP based sustainable heterofunctional material.

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“…For the next 50 years, new developments included the study of the ion-exchange and intercalation chemistry of these materials, − , new nanophases and hybrid materials, layer exfoliation, surface modification, and the application of these materials in catalysis, fuel cells, photophysics and photochemistry, electron-transfer reactions and amperometric biosensors, − vapochromic materials, protein adsorption and intercalation, , and lubricant additives …”

Section: Introductionmentioning

confidence: 99%

New Applications of Zirconium Phosphate Nanomaterials

et al. 2021

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Conspectus The 2-D layers of the inorganic ion exchanger α-zirconium phosphate (Zr(HPO4)2·H2O, α-ZrP) make this compound particularly stable to low pH, high temperature, and ionizing radiation. Initially studied for its ion exchange properties, once the conditions for its synthesis in crystalline form was accomplished by James Stynes and Abraham Clearfield in 1964, numerous other types of studies and applications followed. Extensive studies in the 1960s and 1970s on the thermodynamics of ion exchange led to insights into the intercalation mechanism of this material. The Clearfield group solved the crystal structure in 1968 and refined it in 1977. Powder methods were pioneered by the Clearfield group to solve the structure of this type of materials. In 1968 Giulio Alberti reported means to prepare zirconium phosphonates expanding the chemistry of these layered compounds. New phases of ZrP were also discovered (e.g., γ, θ, λ, τ) and the applications ranged from heterogeneous catalysis to intercalation chemistry and solid-state proton conductors. Methods to exfoliate the layers of ZrP were developed in the 1990s as interest grew in new applications of these types of materials. For example, protein and enzyme intercalation was accomplished starting in the 1990s by the McLendon, Mallouk, and Kumar groups. In the early 2000s, the Colón group pioneered the use of the θ phase of ZrP for the direct intercalation of large inorganic metal complexes that could not be directly intercalated into the α phase. Initial studies in the Colón group ranged from applications of these directly intercalated ZrP derivatives in photophysics and photochemistry, amperometric biosensors, vapochromism, and vapoluminescence. Over the past decade, new applications of these materials have been developed in anticancer drug delivery and electrocatalysis of the oxygen evolution reaction (OER). ZrP has now proven to be a promising drug nanocarrier and its unique chemical microenvironment provided by the α-type layers and the interlayer space enhances catalytic activity for numerous types of reactions. Further elucidation of the catalytic active species under operando conditions as well as the chemical structure of drug-intercalated derivatives should provide new insights that will advance the design and development of new compounds with desired properties. The initial pioneering efforts of Clearfield and Alberti are being continued by numerous research groups providing new exciting areas of development on the chemistry of layered M(IV) phosphate and phosphonate compounds. In this Account we present the efforts of the Colón group during the past decade on studies of the applications of ZrP for anticancer drug delivery and electrocatalysis of the OER.

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Engineering functional inorganic nanobiomaterials: controlling interactions between 2D-nanosheets and enzymes

Abstract: A discussion of recent advances in controlling the enzyme-nanosheet interface, and rational methods to engineer interactions at these interface to build better nanobiomaterials and biodevices is presented.

Cited by 7 publications

References 69 publications

Preparation of double-layered nanosheets containing pH-responsive polymer networks in the interlayers and their conversion into single-layered nanosheets through the cleavage of cross-linking points

Preparation of double-layered nanosheets containing pH-responsive polymer networks in the interlayers and their conversion into single-layered nanosheets through the cleavage of cross-linking points

Revisiting the Old and Golden Inorganic Material, Zirconium Phosphate: Synthesis, Intercalation, Surface Functionalization, and Metal Ion Uptake

New Applications of Zirconium Phosphate Nanomaterials

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