Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation

Kim, Gyeungyun; Lee, Mi Kyung; Ha, Junkyu; Han, Sangrok; Lee, Minhyung

doi:10.1016/j.jconrel.2020.12.053

Cited by 59 publications

(38 citation statements)

References 38 publications

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“…In addition, the same group constituted RBP-linked exosomes (RBP-exo) by linking RBP (a RAGE-binding peptide) to an exosome membrane integral protein Lamp2b, followed by the loading with curcumin. As a result, the curcumin loaded RBP-exo exhibited a higher intracellular curcumin delivery efficacy than curcumin alone or curcumin loaded into unmodified exosomes (Kim et al, 2021). Besides, Bai et al (2020) reported a novel tLyp-1 decorated exosome by transfection of HEK293T cells with tLyp-1-lamp2b.…”

Section: Genetic Engineeringmentioning

confidence: 97%

Exosomes, a New Star for Targeted Delivery

Chen

Wang

Zeng

et al. 2021

Front. Cell Dev. Biol.

159

125

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Exosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing numerous biological molecules including nucleic acids, proteins and lipids, which are thought to play important roles in intercellular communication. As carriers, exosomes hold promise as advanced platforms for targeted drug/gene delivery, owing to their unique properties, such as innate stability, low immunogenicity and excellent tissue/cell penetration capacity. However, their practical applications can be limited due to insufficient targeting ability or low efficacy in some cases. In order to overcome these existing challenges, various approaches have been applied to engineer cell-derived exosomes for a higher selectivity and effectiveness. This review presents the state-of-the-art designs and applications of advanced exosome-based systems for targeted cargo delivery. By discussing experts’ opinions, we hope this review will inspire the researchers in this field to develop more practical exosomal delivery systems for clinical applications.

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Section: Genetic Engineeringmentioning

confidence: 97%

Exosomes, a New Star for Targeted Delivery

Chen

Wang

Zeng

et al. 2021

Front. Cell Dev. Biol.

159

125

View full text Add to dashboard Cite

show abstract

“…Exosomes modified with therapeutic peptides and hydrophobic components such as curcumin can successfully reduce inflammation in the lungs. Therefore, such modified exosomes could be useful in the treatment of fatal respiratory diseases, including acute lung injury [112]. Lipophilic and water-insoluble components are more difficult to deliver to the target site and thus ensure adequate therapeutic efficacy.…”

Section: Incorporation Of Cargo Into Therapeutic Biomaterialsmentioning

confidence: 99%

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Kučuk

Primožič

Knez

et al. 2021

IJMS

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Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety of therapeutic applications due to their unique characteristics, especially due to the ineffectiveness and cytotoxicity of some existing therapies and synthetic therapeutic nanocarriers. They are highly promising as carriers of drugs, genes, and other therapeutic agents that can be incorporated into their interior or onto their surface through various modification techniques to improve their targeting abilities. In addition, they are biocompatible, safe, and stable. The review focuses on different types of exosomes and methods of their preparation, including the incorporation of different kinds of cargo, especially for drug delivery purposes. In particular, their importance and effectiveness as delivery vehicles of various therapeutic agents for a variety of therapeutic applications, including different diseases and disorders such as cancer treatment, cardiovascular and neurodegenerative diseases, are emphasized. Administration routes of exosomes into the body are also included. A novelty in the article is the emphasis on global companies that are already successfully developing and testing such therapeutic biomaterials, with a focus on the most influential ones. Moreover, a comparison of the advantages and disadvantages of the various methods of exosome production is summarized for the first time.

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“…Recently, exosomes have been engineered for the pulmonary delivery of therapeutic peptides and curcumin into the lungs by inhalation [ 129 , 130 ]. These exosomes increased curcumin delivery and pro-inflammatory cytokines in LPS- activated cells.…”

Section: New Nanodelivery Strategies To Increase Pharmacological Activities Of Curcuminmentioning

confidence: 99%

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

et al. 2021

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The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed.

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Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation

Cited by 59 publications

References 38 publications

Exosomes, a New Star for Targeted Delivery

Exosomes, a New Star for Targeted Delivery

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

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