Engineering Cardiovascular Implant Surfaces to Create a Vascular Endothelial Growth Microenvironment

Li, Jingan; Zhang, Kun; Huang, Nan

doi:10.1002/biot.201600401

Cited by 38 publications

(30 citation statements)

References 109 publications

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“…Here, we describe the most significant conductive materials incorporated into hydrogels to impart electroconductivity. Furthermore, while recent publications have detailed different fabrication strategies to form hydrogels with specific architectures [29][30][31], our review focuses on the latest microfabrication techniques used specifically in the fabrication of ECHs. These techniques include 3D printing, electrospinning, micropatterning, and self-assembly.…”

Section: Native Tissuementioning

confidence: 99%

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

156

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Electroconductive hydrogels (ECHs) are highly hydrated three-dimensional (3D) networks generated through the incorporation of conductive polymers, nanoparticles, and other conductive materials into polymeric hydrogels. ECHs combine several advantageous properties of inherently conductive materials with the highly tunable physical and biochemical properties of hydrogels. Recently, the development of biocompatible ECHs has been investigated for various biomedical applications, such as tissue engineering, drug delivery, biosensors, flexible electronics, and other implantable medical devices. Several methods for the synthesis of ECHs have been reported, which include the incorporation of electrically conductive materials such as gold and silver nanoparticles, graphene, and carbon nanotubes, as well as various conductive polymers (CPs), such as polyaniline, polypyrrole, and poly(3,4-ethylenedioxyythiophene) into hydrogel networks. These electroconductive composite hydrogels can be used as scaffolds with high swellability, tunable mechanical properties, and the capability to support cell growth both in vitro and in vivo. Furthermore, recent advancements in microfabrication techniques such as 3D bioprinting, micropatterning, and electrospinning have led to the development of ECHs with biomimetic microarchitectures that reproduce the characteristics of the native extracellular matrix (ECM). The combination of sophisticated synthesis chemistries and modern microfabrication techniques have led to engineer smart ECHs with advanced architectures, geometries, and functionalities that are being increasingly used in drug delivery systems, biosensors, tissue engineering, and soft electronics. In this review, we will summarize different strategies to synthesize conductive biomaterials. We will also discuss the advanced microfabrication techniques used to fabricate ECHs with complex 3D architectures, as well as various biomedical applications of microfabricated ECHs.

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Section: Native Tissuementioning

confidence: 99%

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

156

View full text Add to dashboard Cite

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“…The literature contains many examples of self-dual Leonard pairs. For instance (i) the ated with an irreducible module for the Terwilliger algebra of the hypercube (see [4, Coro Leonard pair of Krawtchouk type (see [10, De nition 6.1]); (iii) the Leonard pair associate module for the Terwilliger algebra of a distance-regular graph that has a spin model in t bra (see [1,Theorem], [3,Theorems 4.1, 5.5]); (iv) an appropriately normalized totally b (see [11,Lemma 14.8]); (v) the Leonard pair consisting of any two of a modular Leonard De nition 1.4]); (vi) the Leonard pair consisting of a pair of opposite generators for th bra, acting on an evaluation module (see [5,Proposition 9.2]). The example (i) is a speci examples (iii), (iv) are special cases of (v).…”

Section: Introductionmentioning

confidence: 99%

Preparing an injectable hydrogel with sodium alginate and Type I collagen to create better MSCs growth microenvironment

Zhou

Zhang

et al. 2019

E-Polymers

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In the past few decades, stem cell transplantation has been generally accepted as an effective method on the treatment of tissue and organ injury. However, the insufficient number of transplanted stem cells and low survival rate that caused by series of negative conditions limit the therapeutic effect. In this contribution, we developed an injectable hydrogel composed of sodium alginate (SA) and Type I collagen (ColI), as the tissue scaffold to create better growth microenvironment for the stem cells. Compared the traditional SA scaffold, the ColI/SA hydrogel inherits its biomimetic properties, and simultaneously has shorter gelation time which means less loss of the transplanted stem cells. The mesenchyma stem cell (MSC) culture experiments indicated that the ColI/SA hydrogel could prevent the MSC apoptosis and contributed to faster MSC proliferation. It is highlighted that this ColI/SA hydrogel may have potential application for tissue regeneration and organ repair as the stem cell scaffold.

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“…In addition, one of the key advantages of natural polymers over synthetic materials is the presence of intrinsic peptide sequences, which can promote cell adhesion and proliferation in vitro [58]. However, although synthetic and even some naturally-derived polymers do not exhibit intrinsic cell supporting capabilities, they can be readily modified through the incorporation of bioactive peptides such as RGD, CAG, REDV, and YIGSR [59,60]. The different types of naturally-derived and synthetic-based biomaterials used in the development of tissue engineered myocardium [61][62][63], cardiac valves [64][65][66][67], and blood vessels [68][69][70][71][72] have been extensively reviewed in the literature and will not be discussed here.…”

Section: Biomimetic Design Of Biomaterials For Cardiovascular Tementioning

confidence: 99%

Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

et al. 2019

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Bioengineered tissues have become increasingly more sophisticated owing to recent advancements in the fields of biomaterials, microfabrication, microfluidics, genetic engineering, and stem cell and developmental biology. In the coming years, the ability to engineer artificial constructs that accurately mimic the compositional, architectural, and functional properties of human tissues, will profoundly impact the therapeutic and diagnostic aspects of the healthcare industry. In this regard, bioengineered cardiac tissues are of particular importance due to the extremely limited ability of the myocardium to self-regenerate, as well as the remarkably high mortality associated with cardiovascular diseases worldwide. As novel microphysiological systems make the transition from bench to bedside, their implementation in high throughput drug screening, personalized diagnostics, disease modeling, and targeted therapy validation will bring forth a paradigm shift in the clinical management of cardiovascular diseases. Here, we will review the current state of the art in experimental in vitro platforms for next generation diagnostics and therapy validation. We will describe recent advancements in the development of smart biomaterials, biofabrication techniques, and stem cell engineering, aimed at recapitulating cardiovascular function at the tissue- and organ levels. In addition, integrative and multidisciplinary approaches to engineer biomimetic cardiovascular constructs with unprecedented human and clinical relevance will be discussed. We will comment on the implementation of these platforms in high throughput drug screening, in vitro disease modeling and therapy validation. Lastly, future perspectives will be provided on how these biomimetic platforms will aid in the transition towards patient centered diagnostics, and the development of personalized targeted therapeutics.

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Engineering Cardiovascular Implant Surfaces to Create a Vascular Endothelial Growth Microenvironment

Cited by 38 publications

References 109 publications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Preparing an injectable hydrogel with sodium alginate and Type I collagen to create better MSCs growth microenvironment

Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

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