Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

Fang, Jun; Hsueh, Yuan Yu; Soto, Jennifer; Sun, Wujin; Wang, Jinqiang; Gu, Zhen; Khademhosseini, Ali; Li, Song

doi:10.1021/acsnano.9b04837

Cited by 44 publications

(47 citation statements)

References 276 publications

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“…Cell reprogramming is the newest technology that can be used in regenerative medicine or in the treatment of genetic diseases. It is known that many physical parameters such as surface topology, stiffness, and charge can influence the reprogramming process [ 200 ]. It has already been shown that a specific surface microstructure is extremely important for cell reprogramming [ 201 ].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Nanomaterial Shape Influence on Cell Behavior

Kladko

Falchevskaya

Serov

et al. 2021

IJMS

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Nanomaterials are proven to affect the biological activity of mammalian and microbial cells profoundly. Despite this fact, only surface chemistry, charge, and area are often linked to these phenomena. Moreover, most attention in this field is directed exclusively at nanomaterial cytotoxicity. At the same time, there is a large body of studies showing the influence of nanomaterials on cellular metabolism, proliferation, differentiation, reprogramming, gene transfer, and many other processes. Furthermore, it has been revealed that in all these cases, the shape of the nanomaterial plays a crucial role. In this paper, the mechanisms of nanomaterials shape control, approaches toward its synthesis, and the influence of nanomaterial shape on various biological activities of mammalian and microbial cells, such as proliferation, differentiation, and metabolism, as well as the prospects of this emerging field, are reviewed.

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Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Nanomaterial Shape Influence on Cell Behavior

Kladko

Falchevskaya

Serov

et al. 2021

IJMS

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“… 165 , 166 Although combining the advantages of vaccine formulations and vaccine delivery devices is promising, micro/macro-engineering still needs to develop solutions that do not require “harsh” conditions to be compatible with nanoengineered formulations. 167 Expectedly, platform technologies that can be quickly adapted to address emerging viral diseases could speed up the pace of vaccine development.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

Engineering Antiviral Vaccines

Zhou

Jiang

et al. 2020

ACS Nano

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Despite the vital role of vaccines in fighting viral pathogens, effective vaccines are still unavailable for many infectious diseases. The importance of vaccines cannot be overstated during the outbreak of a pandemic, such as the coronavirus disease 2019 (COVID-19) pandemic. The understanding of genomics, structural biology, and innate/adaptive immunity have expanded the toolkits available for current vaccine development. However, sudden outbreaks and the requirement of population-level immunization still pose great challenges in today’s vaccine designs. Well-established vaccine development protocols from previous experiences are in place to guide the pipelines of vaccine development for emerging viral diseases. Nevertheless, vaccine development may follow different paradigms during a pandemic. For example, multiple vaccine candidates must be pushed into clinical trials simultaneously, and manufacturing capability must be scaled up in early stages. Factors from essential features of safety, efficacy, manufacturing, and distributions to administration approaches are taken into consideration based on advances in materials science and engineering technologies. In this review, we present recent advances in vaccine development by focusing on vaccine discovery, formulation, and delivery devices enabled by alternative administration approaches. We hope to shed light on developing better solutions for faster and better vaccine development strategies through the use of biomaterials, biomolecular engineering, nanotechnology, and microfabrication techniques.

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“…Indeed, biophysical factors are broadly involved in orchestrating morphogenesis, angiogenesis, and tissue remodeling by modulating cell function and fate. Cells can convert the biomaterial's biophysical features into intracellular biochemical signals via for example mechanosensing resulted in ultimate gene expression 123 . Therefore, the creation of specific morphologies and surface patterns along with optimization of pore size and pore morphology has been shown to influence the growth of interconnected blood vessels within the scaffold and also the degree of vascularization through the mechanisms involving the body's immune system 120,124 .…”

Section: Treatment Of Chronic Wounds Using Angiogenic Approachesmentioning

confidence: 99%

“…There are also several studies that used ECM's derivatives such as proteoglycans and their GAGs as hydrogels or bioactive molecules immobilized onto scaffolds to bind a range of growth factors, cytokines, and chemokines through their GAG chains 123,132 . Among these proteoglycans, research findings confirmed that perlecan, or heparan sulfate proteoglycan 2 (HSPG2), has major roles in tissue and organ development and wound healing by orchestrating the binding of morphogens and delivery of angiogenic factors to cells in a spatiotemporal and dynamic manner 133,134 …”

Section: Treatment Of Chronic Wounds Using Angiogenic Approachesmentioning

confidence: 99%

Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches

Nour

Imani

Chaudhry

et al. 2020

J Biomedical Materials Res

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Skin injuries and in particular, chronic wounds, are one of the major prevalent medical problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration, impaired angiogenesis can cause several complications during the wound healing process and skin regeneration. Therefore, induction or promotion of angiogenesis can be considered as a promising approach to accelerate wound healing. This article presents a comprehensive overview of current and emerging angiogenesis induction methods applied in several studies for skin regeneration, which are classified into the cell, growth factor, scaffold, and biological/chemical compound‐based strategies. In addition, the advantages and disadvantages of these angiogenic strategies along with related research examples are discussed in order to demonstrate their potential in the treatment of wounds.

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Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

Cited by 44 publications

References 276 publications

Nanomaterial Shape Influence on Cell Behavior

Nanomaterial Shape Influence on Cell Behavior

Engineering Antiviral Vaccines

Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches

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