Engineering and characterisation of BCG-loaded polymeric microneedles

Arshad, Muhammad Sohail; Fatima, Sameen; Nazari, Kazem; Ali, Radeyah; Farhan, Muhammad; Muhammad, Syed Aun; Abbas, Nasir; Hussain, Amjad; Küçük, İsrafil; Chang, Ming Wei; Mehta, Prina; Ahmad, Zeeshan

doi:10.1080/1061186x.2019.1693577

Cited by 34 publications

(24 citation statements)

References 29 publications

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“…A closer look at the MN patches reveals high-resolution architecture with fine and sharp tips [181,[183][184][185][186].…”

Section: Characterization Techniques For Polymeric Mnsmentioning

confidence: 99%

“…Scanning electron microscopic (SEM) studies of MN patches are the most common techniques to understand MN morphology [ 181 , 182 ]. Previous research has used SEM studies to examine MN size, shape, height, base, pitch, and other physical attributes [ 36 , 183 ]. For SEM analysis, coating the MNs with a gold solution is used for capturing a clear image using a low voltage (1.0 kV) to avoid any electrical charges on the MNs surface [ 2 , 184 ].…”

Section: Characterization Techniques For Polymeric Mnsmentioning

confidence: 99%

“…The images of coated MNs are captured digitally from a fixed working distance using different magnifications (e.g., 30, 80, 110, or 120×) [ 2 , 164 ]. A closer look at the MN patches reveals high-resolution architecture with fine and sharp tips [ 181 , 183 , 184 , 185 , 186 ].…”

Section: Characterization Techniques For Polymeric Mnsmentioning

confidence: 99%

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Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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“…A closer look at the MN patches reveals high-resolution architecture with fine and sharp tips [181,[183][184][185][186].…”

Section: Characterization Techniques For Polymeric Mnsmentioning

confidence: 99%

Section: Characterization Techniques For Polymeric Mnsmentioning

confidence: 99%

See 1 more Smart Citation

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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“…The potential of electroporation-assisted intramuscular or intradermal administration of DNA vaccines for inducing strong immune responses has already been reported in literature [ 162 ]. Recently, microneedles (25–2000 µm) emerged as one of the most popular routes for vaccine administration due to several advantages, including self-application and cold chain independency (for proteins/vaccines/sensitive drugs) [ 163 , 164 , 165 , 166 ]. Three types of microneedle designs including coated, hollow and dissolving are being used for vaccine delivery [ 167 , 168 ].…”

Section: Routes To Coronavirus Vaccine Deliverymentioning

confidence: 99%

COVID-19: Current Developments and Further Opportunities in Drug Delivery and Therapeutics

et al. 2020

Self Cite

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SARS-CoV-2 has affected people from all age groups, races and ethnicities. Given that many infected individuals are asymptomatic, they transmit the disease to others unknowingly, which has resulted in the spread of infection at an alarming rate. This review aims to provide an overview of the pathophysiology, preventive measures to reduce the disease spread, therapies currently in use, an update on vaccine development and opportunities for vaccine delivery. The World Health Organization has advised several precautions including social distancing, hand washing and the use of PPE including gloves and face masks for minimizing the spread of SARS-CoV-2 infection. At present, several antiviral therapies previously approved for other infections are being repositioned to study their efficacy against SARS-CoV-2. In addition, some medicines (i.e., remdesivir, chloroquine, hydroxychloroquine) have received emergency use authorisation from the FDA. Plasma therapy has also been authorised for emergency use for the treatment of COVID-19 on a smaller scale. However, no vaccine has been approved so far against this virus. Nevertheless, several potential vaccine targets have been reported, and development of different types of vaccines including DNA, mRNA, viral vector, inactivated, subunit and vaccine-like particles is in process. It is concluded that a suitable candidate delivered through an advanced drug delivery approach would effectively boost the immune system against this coronavirus.

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“…Therefore, MNs have garnered great attention for transdermal immunotherapy since they can bypass the stratum corneum layer and directly deliver antibodies, allergens, and therapeutic antigens into the skin, painless and with minimal invasiveness [4,5]. All types of MNs can promote the delivery of immunostimulatory or immunosuppressive payloads into the immune cell-rich microenvironment of the dermis layer [6,7], while controlling the dosage and improving the consistency of therapeutic response is achievable [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Microneedles for painless transdermal immunotherapeutic applications

Amani

Shahbazi

D'Amico

et al. 2021

Journal of Controlled Release

145

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Engineering and characterisation of BCG-loaded polymeric microneedles

Cited by 34 publications

References 29 publications

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

COVID-19: Current Developments and Further Opportunities in Drug Delivery and Therapeutics

Microneedles for painless transdermal immunotherapeutic applications

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