Engineering aluminum hydroxyphosphate nanoparticles with well-controlled surface property to enhance humoral immune responses as vaccine adjuvants

Understanding Structure–Function Relationships of Nanoadjuvants for Enhanced Cancer Vaccine Efficacy

“…In addition, AAHPs with positively charged showed the most significant immunostimulatory effect than neutral or negatively charged nanoparticles. [70] Bilyy et al demonstrated for the first time that long (20-60 microns), small diameter (20-40 nm), and high aspect ratio (>1000) γ-Al 2 O 3 nanowires (NWS) are extremely powerful materials that enhance the body's immune responses to antigens (Figure 5a,b,j). [71] Compared with commercial aluminum oxide microparticles (Al 2 O 3 MPs), the cytotoxicity of γ-Al 2 O 3 nanoparticles is significantly reduced, including damage to microvessels and reduction of edema, and the activation of neutrophils is significantly enhanced (Figure 5c-g).…”

“…In addition, AAHPs with positively charged showed the most significant immunostimulatory effect than neutral or negatively charged nanoparticles. [ 70 ]…”

“…[133,134b] Nanoadjuvants systems can deliver therapeutic agents and treat areas of the body that cannot be reached by other delivery systems. [ 134a,137 ] There are many nanoadjuvants that have a good effect on cancer treatments, [ 138 ] such as polymer nanoadjuvants, and aluminum nanoadjuvants, [ 13,70 ] manganese oxide nanoadjuvants, [ 62 ] iron oxide nanoadjuvants [ 64,139 ] and other metal nanoadjuvants. [ 137 ] As well as some nano‐scale viral vectors, virus‐like particles, irosomes and‐viral vectors, etc.…”

“…c) Schematic representation of the AAHPs formation. Reproduced with permission [70]. Copyright 2021, Elsevier.…”

Nanotechnology-Based Weapons to Combat Human Papillomavirus Infection Associated Diseases

“…Recently, Liang et al showed that the engineered aluminum hydroxyphosphate nanoparticles (AAHPs) could be used to enhance antigen-specific antibody responses induced by HPV18 L1-VLPs by adjusting their surface charge. After a series of experiments, the researchers concluded that the positively charged AAHPs provoked much stronger and long-lasting antigen-specific humoral immune responses compared to their negatively charged or neutral counterparts ( Liang et al, 2021 ). As an adjuvant of synthetic long peptides (from HPV16 E6 and E7 oncoproteins), mineral oil can help to form a persistent release depot but with severe adverse and long-lasting side effects.…”