Engineering a multifunctional N-halamine-based antibacterial hydrogel using a super-convenient strategy for infected skin defect therapy

Chen, Wanjun; Zhu, Yingnan; Zhang, Zhe; Gao, Yue; Liu, Wenxin; Borjihan, Qinggele; Qu, Huihui; Zhang, Yana; Zhang, Yanling; Wang, Yanjie; Zhang, Lei; Dong, Alideertu

doi:10.1016/j.cej.2019.122238

Cited by 44 publications

(25 citation statements)

References 64 publications

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“…Antibacterial tests of the CS‐GA‐Hs were evaluated by the reported method with some modification 23–25 . Typical Gram‐positive Staphylococcus aureus ( S. aureus , ATCC 27661) and Gram‐negative Escherichia coli ( E. coli , ATCC 25933) were used as test microorganisms in this study.…”

Section: Methodsmentioning

confidence: 99%

“…Antibacterial tests of the CS-GA-Hs were evaluated by the reported method with some modification. [23][24][25] Typical Gram-positive Staphylococcus aureus (S. aureus, ATCC 27661) and Gram-negative Escherichia coli (E. coli, ATCC 25933) were used as test microorganisms in this study. Each bacterium was inoculated into TSB, cultured in a shaking incubator at 37 C for 24 h and adjusted to approximately 10 6 CFU mL −1 before testing.…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

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Preparation and characterization of ethanol‐induced chitosan‐glutaric anhydride hydrogel for biomedical applications

Zhou

Huang

et al. 2020

J of Applied Polymer Sci

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Here we report a novel, fast, and facile sythesis of chitosan-based hydrogels by ethanol directly inducing. In the present of ethanol, chitosan (CS) with glutaric anhydride (GA) could form hydrogels (CS-GA-Hs) just in few minutes. The results of 1 H NMR and FTIR confirmed N-acylation substitution of chitosan. Furthermore, the relative concentration of GA was also the critical parameter for formation and properties of CS-GA-Hs. When the concentration was 1.5, CS-GA-Hs showed the highest swelling (253.6%) and release degree (99.9%). The porous structure of CS-GA-Hs were observed by SEM and the pore size of the gels decreased from 500 to 200 μm, when the relative concentration of GA was changed from 1.5 to 4. And all the hydrogels were demonstrated a good mechanical properties. Additionally, the CS-GA-Hs showed in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli, and no cytotoxicity toward L929 mouse fibroblasts, meaning it has potential applications in biomedical fields.

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Section: Methodsmentioning

confidence: 99%

Section: Antibacterial Propertiesmentioning

confidence: 99%

Preparation and characterization of ethanol‐induced chitosan‐glutaric anhydride hydrogel for biomedical applications

Zhou

Huang

et al. 2020

J of Applied Polymer Sci

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“…To endow fabrics with antibacterial activity, ciprofloxacin [ 7 ], metal salts and nanoparticles [ 8 – 10 ], metallic oxide [ 11 ], rose Bengal [ 12 ], chitosan [ 13 – 15 ], betaine [ 16 , 17 ], surface stereochemistry [ 18 ], quaternary ammonium salt(QAS) [ 19 – 21 ]. dopamine-menthol [ 22 ], guanidine [ 23 , 24 ], and N -halamine [ 25 – 27 ] have been developed, and impressive achievements have been gained. Among them , N -halamine has become a popular antimicrobial due to its remarkable antibacterial activity against wide-spectrum pathogens even drug-resistant pathogenic bacteria [ 25 , 28 ], rapidly inactivating bacteria [ 29 ], and reproducible biocidal activity [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…dopamine-menthol [ 22 ], guanidine [ 23 , 24 ], and N -halamine [ 25 – 27 ] have been developed, and impressive achievements have been gained. Among them , N -halamine has become a popular antimicrobial due to its remarkable antibacterial activity against wide-spectrum pathogens even drug-resistant pathogenic bacteria [ 25 , 28 ], rapidly inactivating bacteria [ 29 ], and reproducible biocidal activity [ 30 , 31 ]. Moreover, strenuous efforts have been made to develop N -halamine as disinfectants [ 32 , 33 ] for water treatment [ 30 ], food packaging [ 34 , 35 ], hydrogel [ 25 ], and antibacterial fabrics [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Leaching, Rapid Bactericidal and Biocompatible Polyester Fabrics Finished with Benzophenone Terminated N-halamine

Wang

Cao

et al. 2021

Adv. Fiber Mater.

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Pathogenic bacteria can proliferate rapidly on porous fabrics to form bacterial plaques/biofilms, resulting in potential sources of cross-transmissions of diseases and increasing cross-infection in public environments. Many works on antibacterial modification of cotton fabrics have been reported, while very few works were reported to endow poly(ethylene terephthalate) (PET) fabrics with non-leaching antibacterial function without compromising their innate physicochemical properties though PET is the most widely used fabric. Therefore, it is urgent to impart the PET fabrics with non-leaching antibacterial activity. Herein, a novel N- halamine compound, 1-chloro-3-benzophenone-5,5-dimethylhydantoin (Cl-BPDMH), was developed to be covalently bonded onto PET fabrics, rendering non-leaching antibacterial activity while negligible cytotoxicity based on contact-killing principle. Bacterial was easily adhered to Cl-BPDMH finished PET fabrics, and then it was inactivated quickly within 10 s. Furthermore, the breaking strength, breaking elongation, tearing strength, water vapor permeability, air permeability and whiteness of Cl-BPDMH finished PET fabrics were improved obviously compared to raw PET fabrics. Hence, this work developed a facile approach to fabricate multifunctional synthetic textiles to render outstanding and rapid bactericidal activity without compromising their physicochemical properties and biocompatibility. Supplementary Information The online version contains supplementary material available at 10.1007/s42765-021-00100-z.

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“…N-halamines, a group of compounds containing one or more nitrogen-halogen covalent bonds, have been increasingly used in antibacterial applications, because of their excellent antibacterial activity, biosafety, and environment-friendliness [6][7][8][9][10]. They can be produced by bonding nitrogen on the inorganic or organic compounds and oxidative halogens [11].…”

Section: Introductionmentioning

confidence: 99%

Highly Antibacterial Efficacy of a Cotton Fabric Treated with Piperazinyl Schiff Base

et al. 2021

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Due to the structure of hierarchical aligned cellulose fibrils, cotton fabric used in clothing possesses excellent moisture and thermal managements. Such structure yet may retain metabolic excrements and sebum secretions discharged from the human skin, which reproduce microorganisms harmful for human health. However, incorporating the antimicrobial coating into the cotton fabric can sufficiently resist the microorganism growth. In this work, a water-soluble antibacterial coating named N-(4-(allyloxy) benzylidene)-2-(piperazin-1-yl) ethanamine (NABPE) was synthesized to produce a rechargeable and fast sterilization cotton fiber fabric (M-cotton/NABPE). M-cotton/NABPE exhibited a high effective antibacterial activity, and the inhibition ratios against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were 94 % and 93 %, respectively. Chlorination was performed with sodium hypochlorite solution to form N-Cl bond on the Mcotton/NABPE fabrics, resulting in a high biocidal efficacy of up to 100 % via contact killing for a duration of 5 min. After 25 washing cycles, the antibacterial fabric still maintained an antibacterial rate of 91.95 % and 92.15 % against E. coli and S. aureus, respectively. Furthermore, the fabrics showed integrated properties of excellent UV stability, long-term stability, robust rechargeable biocidal activity (chlorine recharging >5000 ppm) and washing durability. This research provides fundamental insights into the synthesis of the NABPE and prolonged biocidal efficacy of the M-cotton/NABPE, and thereby pave a pathway to incorporate an economic and environmental-friendly antibacterial coating suitable for finishing cotton fabric.

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Engineering a multifunctional N-halamine-based antibacterial hydrogel using a super-convenient strategy for infected skin defect therapy

Cited by 44 publications

References 64 publications

Preparation and characterization of ethanol‐induced chitosan‐glutaric anhydride hydrogel for biomedical applications

Preparation and characterization of ethanol‐induced chitosan‐glutaric anhydride hydrogel for biomedical applications

Non-Leaching, Rapid Bactericidal and Biocompatible Polyester Fabrics Finished with Benzophenone Terminated N-halamine

Highly Antibacterial Efficacy of a Cotton Fabric Treated with Piperazinyl Schiff Base

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