Engineered Swine Models of Cancer

Watson, Adrienne L.; Carlson, Daniel F.; Largaespada, David A.; Hackett, Perry B.; Fahrenkrug, Scott C.

doi:10.3389/fgene.2016.00078

Cited by 54 publications

(51 citation statements)

References 103 publications

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“…However, there is established recognition of the utility of large animal models in preclinical and translational studies of disease, which may better predict laboratory bench-to-clinical success. In particular, mini-pigs are excellent candidates for large animal studies due to their remarkable physiologic and size similarity to humans [2,3]. Size similarity is especially important in studies of locoregional intervention by percutaneous techniques [4] and also of investigations utilizing noninvasive radiofrequency hyperthermia, where size and geometry are critical effectors of regional specific absorption rates and thus tissue temperature [5,6].…”

Section: Introductionmentioning

confidence: 99%

Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs

Ware

Law

et al. 2018

Oncology

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Large animal models are important tools for hepatocellular carcinoma (HCC) research, especially in studies of hepatic vasculature, interventional techniques, and radiofrequency or microwave hyperthermia. Currently, diethylnitrosamine (DENA)-induced HCC in pigs is the only large animal model for in situ HCC with a tumor latency of 10–26 months. While phenobarbital (PB) is often used to accelerate DENA-induced HCC in rodents, it has not been previously studied in the porcine model. Therefore, we hypothesize that the addition of PB in the DENA-induced HCC porcine model will accelerate tumor latency compared to DENA alone. HCC and benign lesions were seen on serial MRI and confirmed on histopathology. Liver and tumors were further characterized by CT angiography, vascular corrosion casting, and permittivity measurements.

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Section: Introductionmentioning

confidence: 99%

Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs

Ware

Law

et al. 2018

Oncology

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“…Spontaneous and transgenic large animal tumor models like engineered swine cancer models may be more valuable for preclinical studies in terms of clinical relevance and their safety and toxicity testing. [161] …”

Section: Discussionmentioning

confidence: 99%

Emerging Roles of Electrospun Nanofibers in Cancer Research

Chen

Boda

Batra

et al. 2017

Adv Healthcare Materials

120

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This article reviews the recent progress of electrospun nanofibers in cancer research. It begins with a brief introduction to the emerging potential of electrospun nanofibers in cancer research. Next, a number of recent advances on the important features of electrospun nanofibers critical for cancer research are discussed including the incorporation of drugs, control of release kinetics, orientation and alignment of nanofibers, and the fabrication of 3D nanofiber scaffolds. This article further highlights the applications of electrospun nanofibers in several areas of cancer research including local chemotherapy, combinatorial therapy, cancer detection, cancer cell capture, regulation of cancer cell behavior, construction of in vitro 3D cancer model, and engineering of bone microenvironment for cancer metastasis. This progress report concludes with remarks on the challenges and future directions for design, fabrication, and application of electrospun nanofibers in cancer diagnostics and therapeutics.

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“…Growth dynamic of the pig provides a biological model of the growth in mammals including humans. In research on cancer, pigs maybe are the best model due to their size, physiological, genetic, and biochemical similarities to humans (Watson et al 2016). In some instances, the findings can be translated to man, in others they apply to animal.…”

Section: Introductionmentioning

confidence: 99%

A Model of Animals Phenotype with Superior Growth

Stass¹

2020

IJB

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The aim of this study is to model and analyse a dynamic of feed conversion coefficient in pigs' ontogeny. Feed conversion is a process that couples feed intake, and growth. While there has been much research into the problem, a quantitative relation between the traits has not been revealed. The study considers feed as nutrient weight rather than its energy or a separate feedstuff. A main task of the research is to find out an analytical function between the traits. It is expected that the study will provide a new insight into the problem. Animals are open systems; they need feed to sustain life, to grow and develop. It is plausible to suppose that growth of animal is a function of feed conversion and body weight. To find out and analyse this function a deterministic model of growth was built. The model was built as a dynamic system that describes the growth of individual animals. Both continuum and discrete-time modelling techniques are employed. The model is based on a data set obtained in experiments and field observations. Theoretical notions about the growth have been used for the model analyses. It is shown that in ontogeny feed conversion and growth rate are functionally related traits. Between the traits, there is a nonlinear relation that concerns the growth rate, and feed conversion coefficient. In the model, the feed conversion coefficient is the variable that determines the dynamic of growth.

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Engineered Swine Models of Cancer

Cited by 54 publications

References 103 publications

Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs

Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs

Emerging Roles of Electrospun Nanofibers in Cancer Research

A Model of Animals Phenotype with Superior Growth

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