“…Several ADCs have gained regulatory approval and many others are in clinical development [ 182 , 183 ]. Anti-ICPML ADCs against several ICPMs (e.g., PD-L1, CD70, B7-H3, B7-H4, TIM-1) have been reported and some are in active clinical development while the development of some others has been discontinued because of marginal single-agent activity or unacceptable toxicity [ 131 , 139 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 ].…”