Engineered extracellular vesicles (EVs): Promising diagnostic/therapeutic tools for pediatric high-grade glioma

Lyu, Yuan; Guo, Y. P.; Okeoma, Chioma M.; Yan, Zheng‐Guang; Hu, Nan; Li, Zian; Zhou, Shaolong; Zhao, Xiaoe; Li, Junqi; Wang, Xinjun

doi:10.1016/j.biopha.2023.114630

Cited by 5 publications

(1 citation statement)

References 184 publications

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“…In this respect, while many efforts have been addressed to the EV‐guided delivery of therapies for gliomas, 134 , 135 , 136 the research focused on EVs as a supporting tool for image‐guided surgery is still growing. 137 Furthermore, although recent advances have been made in the development of methods for the large‐scale production of EVs, 138 the main weakness in the translation of this approach into clinical practice is the lack of a clinically relevant number of EVs, ensuring their integrity and biological activity.…”

Section: Nanosystems For Fgsmentioning

confidence: 99%

Next‐generation agents for fluorescence‐guided glioblastoma surgery

Chirizzi,

Pellegatta,

Gori

et al. 2023

Bioengineering & Transla Med

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Glioblastoma is a fast‐growing and aggressive form of brain cancer. Even with maximal treatment, patients show a low median survival and are often subjected to a high recurrence incidence. The currently available treatments require multimodal management, including maximal safe surgical resection, followed by radiation and chemotherapy. Because of the infiltrative glioblastoma nature, intraoperative differentiation of cancer tissue from normal brain parenchyma is very challenging, and this accounts for the low rate of complete tumor resection. For these reasons, clinicians have increasingly used various intraoperative adjuncts to improve surgical results, such as fluorescent agents. However, most of the existing fluorophores show several limitations such as poor selectivity, photostability, photosensitization and high costs. This could limit their application to successfully improve glioblastoma resection. In the present perspective, we highlight the possibility to develop next‐generation fluorescent tools able to more selectively label cancer cells during surgical resection.

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Section: Nanosystems For Fgsmentioning

confidence: 99%

Next‐generation agents for fluorescence‐guided glioblastoma surgery

Chirizzi,

Pellegatta,

Gori

et al. 2023

Bioengineering & Transla Med

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MicroRNAs in adult high-grade gliomas: Mechanisms of chemotherapeutic resistance and their clinical relevance

Jegathesan,

Stephen,

Sati

et al. 2024

Biomedicine & Pharmacotherapy

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Extracellular vesicles modulate key signalling pathways in refractory wound healing

Yang,

Lin,

Huang

et al. 2023

Burns &Amp; Trauma

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Chronic wounds are wounds that cannot heal properly due to various factors, such as underlying diseases, infection or reinjury, and improper healing of skin wounds and ulcers can cause a serious economic burden. Numerous studies have shown that extracellular vesicles (EVs) derived from stem/progenitor cells promote wound healing, reduce scar formation and have significant advantages over traditional treatment methods. EVs are membranous particles that carry various bioactive molecules from their cellular origins, such as cytokines, nucleic acids, enzymes, lipids and proteins. EVs can mediate cell-to-cell communication and modulate various physiological processes, such as cell differentiation, angiogenesis, immune response and tissue remodelling. In this review, we summarize the recent advances in EV-based wound healing, focusing on the signalling pathways that are regulated by EVs and their cargos. We discuss how EVs derived from different types of stem/progenitor cells can promote wound healing and reduce scar formation by modulating the Wnt/β-catenin, phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin, vascular endothelial growth factor, transforming growth factor β and JAK–STAT pathways. Moreover, we also highlight the challenges and opportunities for engineering or modifying EVs to enhance their efficacy and specificity for wound healing.

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Engineered extracellular vesicles (EVs): Promising diagnostic/therapeutic tools for pediatric high-grade glioma

Cited by 5 publications

References 184 publications

Next‐generation agents for fluorescence‐guided glioblastoma surgery

Next‐generation agents for fluorescence‐guided glioblastoma surgery

MicroRNAs in adult high-grade gliomas: Mechanisms of chemotherapeutic resistance and their clinical relevance

Extracellular vesicles modulate key signalling pathways in refractory wound healing

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