Engineered emulsions for obesity treatment

Madadlou, Ashkan; Rakhshi, Elham; Abbaspourrad, Alireza

doi:10.1016/j.tifs.2016.04.009

Cited by 29 publications

(7 citation statements)

References 67 publications

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“…Emulsion gelation within the stomach is considered a promising method of preventing emulsion destabilization. In addition, the emulsions that gel intragastrically are anticipated to be highly potent at slowing down the emptying of the stomach, thereby providing an increased sense of fullness (Madadlou, Rakhshi, & Abbaspourrad, 2016).…”

Section: Introductionmentioning

confidence: 99%

Rheological and microstructural behaviour of xanthan gum and xanthan gum-Tween 80 emulsions during in vitro digestion

2019

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The rheological, texture and microstructure properties of xanthan gum (XG) water solutions and XG emulsions, with and without Tween 80, were investigated and related to the emulsion fat lipolysis during in vitro digestion. The effect of digestion on the rheological properties of XG aqueous dispersions and XG-containing emulsions was quite different. The viscoelastic moduli G' and G'' of XG aqueous dispersion decreased after stomach digestion, while an increase was found in the XG emulsion without Tween 80. The viscoelasticity results were explained by the microstructure observations, where fat coagulation in the stomach in vitro model (pH 2.5 and pepsin) is observed in the absence of Tween 80, associated with the weaknesses of the XG structure at acidic pH. In all the systems, a decrease in the viscoelastic properties was observed after intestine digestion. In comparison to control emulsions without XG, the XG emulsions partially resist the digestion process, decreasing the quantity of free fatty acids (FFA). In the presence of Tween 80, the decrease in fat digestion was enhanced, the XG-Tween 80 emulsion being the one with the lowest fat digestibility. These results may have important implications for the design of satiating food and food with low fat digestibility.

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Section: Introductionmentioning

confidence: 99%

Rheological and microstructural behaviour of xanthan gum and xanthan gum-Tween 80 emulsions during in vitro digestion

2019

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“…Cellulose and chitin-based particles are resistant to digestive enzymes and gastric acids (Madadlou et al 2016). The rate of in vitro lipid digestion for chitin-stabilized Pickering emulsions was reported to be slower than whey protein or caseinate-stabilized Pickering emulsions…”

Section: Other Novel Delivery Systemsmentioning

confidence: 99%

Lipid digestion of oil-in-water emulsions stabilized with low molecular weight surfactants

Chen

Ghazani

et al. 2019

Food Funct.

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“…Obesity, along with a plethora of associated co-morbidities, is the leading cause of early mortalities worldwide. − Although obesity can typically be prevented and treated with behavioral modifications, such as healthier dietary choices and increased physical activity, the cumulative prevalence and demand placed on healthcare systems call for the urgent development of new and improved therapies to treat this disease . Several “quick fix” treatment approaches for obesity already exist, including surgical procedures and medical treatments, which have revealed varying efficacies in promoting weight reductions. − However, such regimens are linked with an array of adverse health risks and do not lead to desired and healthy behavioral modifications, thereby leading to reduced long-term success. , Subsequently, it has been proposed that new therapeutic strategies should focus on promoting healthy lifestyle changes through the supplementation of functional foods and nutraceuticals that aid in overcoming physiological and psychological conditions associated with obesity. , …”

Section: Introductionmentioning

confidence: 99%

“…8,9 Subsequently, it has been proposed that new therapeutic strategies should focus on promoting healthy lifestyle changes through the supplementation of functional foods and nutraceuticals that aid in overcoming physiological and psychological conditions associated with obesity. 10,11 In recent years, increasing attention has been afforded to food-grade biomaterials that exert anti-obesity effects through the impediment of fat digestion and absorption pathways. 12 Of such materials, high surface area colloids, such as smectite clays and mesoporous silica, have demonstrated excellent promise in provoking weight reductions when supplemented to rodents exposed to high-fat diets (HFDs).…”

Section: ■ Introductionmentioning

confidence: 99%

Contrasting Anti-obesity Effects of Smectite Clays and Mesoporous Silica in Sprague-Dawley Rats

Joyce

Dening

Meola

et al. 2020

ACS Appl. Bio Mater.

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Porous colloids have been shown to exert unique bioactivities for mediating lipid (fat) metabolism and thereby offer significant potential as anti-obesity therapies. In this study, we compare the capacity for two classes of colloids, that is, smectite clays (Laponite XLG, LAP; montmorillonite, MMT) and mesoporous silica (SBA-15 ordered silica; MPS), to impede intestinal lipid hydrolysis and provoke lipid and carbohydrate excretion through adsorption within their particle matrices. A two-stage in vitro gastrointestinal lipolysis model revealed the capacity for both smectite clays and MPS to inhibit the rate and extent of lipase-mediated digestion under simulated fed state conditions. Each system adsorbed more than its own weight of organic media (i.e., lipid and carbohydrates) after 60 min lipolysis, with MMT adsorbing >10% of all available organics through the indiscriminate adsorption of fatty acids and glycerides. When co-administered with a high-fat diet (HFD) to Sprague-Dawley rats, treatment with MMT and MPS significantly reduced normalized rodent weight gain compared to a negative control, validating their potential to restrict energy intake and serve as anti-obesity therapies. However, in vitro–in vivo correlations revealed poor associations between in vitro digestion parameters and normalized weight gain, indicating that additional/alternate anti-obesity mechanisms may exist in vivo, while also highlighting the need for improved in vitro assessment methodologies. Despite this, the current findings emphasize the potential for porous colloids to restrict weight gain and promote anti-obesity effects to subjects exposed to a HFD and should therefore drive the development of next-generation food-grade biomaterials for the treatment and prevention of obesity.

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Engineered emulsions for obesity treatment

Cited by 29 publications

References 67 publications

Rheological and microstructural behaviour of xanthan gum and xanthan gum-Tween 80 emulsions during in vitro digestion

Rheological and microstructural behaviour of xanthan gum and xanthan gum-Tween 80 emulsions during in vitro digestion

Lipid digestion of oil-in-water emulsions stabilized with low molecular weight surfactants

Contrasting Anti-obesity Effects of Smectite Clays and Mesoporous Silica in Sprague-Dawley Rats

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