Engineered borate ester conjugated protein-polymer nanoconjugates for pH-responsive drug delivery

Zhou, Pei; Wu, Shuang; Hegazy, Mohammad; Li, Hong; Xu, Xueju; Lű, He

doi:10.1016/j.msec.2019.109914

Cited by 29 publications

(14 citation statements)

References 72 publications

(68 reference statements)

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“…The K b range is 4.5 × 10 3 to 3.8 × 10 5 L∙mol −1 and the binding site number is equivalent to 1. The experimental results show that complexes 1 – 6 can effectively bind to BSA, affecting the microenvironment of Trp residues and bringing drugs into the target cells to promote apoptosis [ 40 , 41 , 42 ]. It can be seen in Figure 7 that the absorption spectra of the complexes partially overlap with the excitation spectrum of BSA.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents

et al. 2020

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Six new zinc(II) complexes were prepared by the reaction of ZnBr2 or ZnI2 with 4′-(substituted-phenyl)-2,2′:6′,2′′-terpyridine compounds, bearing p-methylsulfonyl (L1), p-methoxy (L2) and p-methyl (L3), which were characterized by elemental analysis, FT-IR, NMR and single crystal X-ray diffraction. The antiproliferative properties against Eca-109, A549 and Bel-7402 cell lines and the cytotoxicity test on RAW-264.7 of these compounds were monitored using a CCK-8 assay, and the studies indicate that the complexes show higher antiproliferative activities than cisplatin. The interactions of these complexes with CT-DNA and proteins (BSA) were studied by UV-Vis, circular dichroism (CD) and fluorescent spectroscopy, respectively. The results indicate that the interaction of these zinc(II) complexes with CT-DNA is achieved through intercalative binding, and their strong binding affinity to BSA is fulfilled through a static quenching mechanism. The simulation of the complexes with the CT-DNA fragment and BSA was studied by using molecular docking software. It further validates that the complexes interact with DNA through intercalative binding mode and that they have a strong interaction with BSA.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents

et al. 2020

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“…PBAs were utilized as H 2 O 2 -responsive moieties to synthesize ROS-responsive anti-inflammatory materials. Moreover, the ester bonds formed by PBAs and o -diol are easily broken in acidic environments, which is often used to prepare pH-responsive materials 60 - 62 .…”

Section: Resultsmentioning

confidence: 99%

Microenvironment Activatable Nanoprodrug Based on Gripper-like Cyclic Phenylboronic Acid to Precisely and Effectively Alleviate Drug-induced Hepatitis

Zhang¹,

Li²,

Cai³

et al. 2021

Theranostics

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Drug-induced hepatitis (DIH), which seriously interferes with disease treatment, is one of the most common reasons for termination of new drugs during preclinical studies or post-marketing surveillance. Although antioxidants and anti-inflammatory agents are promising, their nonspecific distribution and insolubility limit their application. Therefore, precise drug release at the disease site is an important way to alleviate DIH and avoid side effects. Methods: A gripper-like hydrophilic cyclic phenylboronic acid (cPBA) was synthesized and a nanoprodrug (cPBA-BE) was established by coupling cPBA with hydrophobic baicalein (BE). The stimuli-responsive release properties and therapeutic effect of cPBA-BE on drug-injured hepatocyte were investigated. The biodistribution and therapeutic effect of cPBA-BE both in acetaminophen-induced acute hepatitis model and rifampicin-induced chronic hepatitis model were further evaluated. Results: cPBA-BE conjugate could self-assemble into nanoprodrug with cPBA as the hydrophilic external layer and BE as the hydrophobic core. In HepaRG cells, cPBA-BE showed stronger cellular uptake. Due to the H 2 O 2 - and acid-sensitivity, cPBA-BE could achieve adequate BE release, significantly resist the depletion of GSH, mitochondrial dysfunction, downregulation of inflammation and cell apoptosis in the acetaminophen injured HepaRG cells. Biodistribution showed that cPBA-BE specifically increased the concentration of BE in the liver of DIH mice. cPBA-BE could alleviate acetaminophen-induced acute hepatitis or rifampicin-induced chronic hepatitis more effectively through relieving the oxidative stress, inflammation and block the neutrophil infiltration in liver. Conclusions: cPBA is expected to be a good platform for constructing injectable nanoprodrug with both H 2 O 2 and pH-responsive properties by coupling a wide range of drugs containing o -diol. In this study, the nanoprodrug cPBA-BE was determined to be effective for alleviating the DIH.

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“…As a proof of concept, PNIPAAm was synthesized according to our reported protocol [ 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. The as-generated mercaptothiazoline-activated PNIPAAm (Mn = 9600 g mol −1 , PDI = 1.2, ca.…”

Section: Resultsmentioning

confidence: 99%

Engineering Au Nanoclusters for Relay Luminescence Enhancement with Aggregation-Induced Emission

et al. 2022

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The research of aggregation-induced emission (AIE) has been growing rapidly for the design of highly luminescent materials, as exemplified by the library of AIE-active materials (or AIEgens) fabricated and explored for diverse applications in different fields. Herein, we reported a relay luminescence enhancement of luminescent Au nanoclusters (Au NCs) through AIE. In addition, we demonstrated the emergence of reduced aggregation-caused luminescence by adjusting the temperature of the Au NC solution. The key to induce this effect is to attach a thermosensitive polymer poly(N-isopropylacrylamide) (PNIPAAm) on the surface of Au NCs, which will shrink at high temperature. More interestingly, the as-synthesized Au NCs-PNIPAAm can self-assemble into vesicles, resulting in an obvious decrease in the luminescence intensity in aqueous solution. The combination of relay luminescence enhancement (by AIE) and luminescence decrease (induced by thermosensitive polymers) will be beneficial to the understanding and manipulation of the optical properties of Au NCs, paving the way for their practical applications.

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Engineered borate ester conjugated protein-polymer nanoconjugates for pH-responsive drug delivery

Cited by 29 publications

References 72 publications

Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents

Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents

Microenvironment Activatable Nanoprodrug Based on Gripper-like Cyclic Phenylboronic Acid to Precisely and Effectively Alleviate Drug-induced Hepatitis

Engineering Au Nanoclusters for Relay Luminescence Enhancement with Aggregation-Induced Emission

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