Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents

Abstract

Six new zinc(II) complexes were prepared by the reaction of ZnBr2 or ZnI2 with 4′-(substituted-phenyl)-2,2′:6′,2′′-terpyridine compounds, bearing p-methylsulfonyl (L1), p-methoxy (L2) and p-methyl (L3), which were characterized by elemental analysis, FT-IR, NMR and single crystal X-ray diffraction. The antiproliferative properties against Eca-109, A549 and Bel-7402 cell lines and the cytotoxicity test on RAW-264.7 of these compounds were monitored using a CCK-8 assay, and the studies indicate that the complexes show higher antiproliferative activities than cisplatin. The interactions of these complexes with CT-DNA and proteins (BSA) were studied by UV-Vis, circular dichroism (CD) and fluorescent spectroscopy, respectively. The results indicate that the interaction of these zinc(II) complexes with CT-DNA is achieved through intercalative binding, and their strong binding affinity to BSA is fulfilled through a static quenching mechanism. The simulation of the complexes with the CT-DNA fragment and BSA was studied by using molecular docking software. It further validates that the complexes interact with DNA through intercalative binding mode and that they have a strong interaction with BSA.

Antitumoral Properties of a Pincer-Type Isonicotinohydrazone-Hg(II) Complex

“…If DNA and small molecules perform groove bonding or electrostatic attraction between them, a hyperchromic effect showing conformational changes in the structure is observed, and a slight redshift can be observed. The hyperchromic effect and blueshift observed in the figure indicate that PTIH interacts with CT-DNA via groove binding and/or electrostatic attraction (42)(43)(44)(45). Kb value of PTIH indicates that it has a good binding affinity with DNA in comparison with the Kb value for classical intercalator ethidium bromide (Kb=1.4x10 5 M -1 ) (46) and resembles studies in the literature (47,48).…”

A New Concept of Enhancing the Anticancer Activity of Manganese Terpyridine Complex by Oxygen-Containing Substituent Modification

“…In order to clarify the effect of oxygen-containing substituent modification on the anticancer activity of terpyridine complexes, we summarized the anticancer activities of a total of 28 substituted terpyridine complexes against different cancer cells in Figure 7 from this work and previously reported works [ 44 , 65 ]. When the average activity of the non-oxygen-containing substituent-modified terpyridine complexes is compared with that of the terpyridine complexes modified with oxygen-containing substituents, we can clearly find that oxygen-containing substituents brought a significant increase in anticancer activity.…”

“… The in vitro anticancer activity of substituted 2,2′:6′,2″-terpyridine(tpy) complexes 1a – 1c , 2a – 2h , 3a – 3k [ 65 ] and 4a – 4f [ 44 ] against different cancer cell lines, including A549, Bel-7402, Eca-109, HeLa and MCF-7. The heights of the blue and red blocks on the background represent the average performance of the anticancer activity of the non-oxygen-containing substituents and oxygen-containing substituent-modified complexes, respectively.…”

“…Therefore, they have important research and application prospects in the fields of luminescent materials, photodynamic therapy and chemical sensors [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. After the success of cisplatin and carboplatin in cancer chemotherapy, other transition metal ions have been of great interest, since they are involved in many biological processes [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Among them, manganese is used to synthesize new complexes that exhibit excellent antibacterial and antitumor activity [ 46 , 47 , 48 ].…”

Cobalt(ii) terpyridine complexes: synthesis, characterization, antiproliferative activity and molecular docking with proteins and DNA

“…For example, several complexes with Zn(II), Cu(II), Pt(II) and Ru(II) have been reported with high anticancer activity. [18][19][20][21] Particularly, Pt and a School of Chemistry and Chemical Engineering, Guangxi University, 530004…”