Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Long, Quan; Zheng, Peng; Zheng, Xiao; Li, Weiran; Hua, Liangqun; Yang, Zhongqian; Huang, Weiwei; Ma, Yanbing

doi:10.1016/j.addr.2022.114321

Cited by 47 publications

(59 citation statements)

References 334 publications

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“…Based on the sourcing and the manufacturing process, bacteria-derived nanovesicles can be divided into five categories, including membrane vesicles (G + bacteria release), outer membrane vesicles (G − bacteria produce), double-layered membrane vesicles (via chemical/ physical breakdown), protoplast-derived nanovesicles (derived from bacteria inner membranes), and minicells (originate from abnormal bacteria division). 45 Despite their different bio-genesis routes, they all contain membrane proteins, lipoproteins, peptidoglycans, lipopolysaccharides, and nucleic acid, with different composition ratios. 46 Therefore, in this section, we will not strictly distinguish the nanovesicle type, but emphasize the nanotechnology-based engineering strategies for strengthening these bacteria-derived nanovesicles for cancer immunotherapy.…”

Section: Nanotechnologymentioning

confidence: 99%

Engineered bacteria for augmentedin situtumor vaccination

et al. 2023

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Section: Nanotechnologymentioning

confidence: 99%

Engineered bacteria for augmentedin situtumor vaccination

et al. 2023

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“…Bacterium can release these useless or even harmful substances to reduce the pressure in the interest of survival. This effect can be observed by treating Pseudomonas aeruginosa with epoxy floxacin; in the event of DNA damage, the bacteria initiate an emergency rescue mechanism that increases the number of OMVs released so that it is more conducive to fighting the injury and harsh living environment (46).…”

Section: Formation Of Bacterial Outer Membrane Vesiclesmentioning

confidence: 99%

Bacterial outer membrane vesicles as a candidate tumor vaccine platform

et al. 2022

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Cancer represents a serious concern for human life and health. Due to drug resistance and the easy metastasis of tumors, there is urgent need to develop new cancer treatment methods beyond the traditional radiotherapy, chemotherapy, and surgery. Bacterial outer membrane vesicles (OMVs) are a type of double-membrane vesicle secreted by Gram-negative bacteria in the process of growth and life, and play extremely important roles in the survival and invasion of those bacteria. In particular, OMVs contain a large number of immunogenic components associated with their parent bacterium, which can be used as vaccines, adjuvants, and vectors to treat diseases, especially in presenting tumor antigens or targeted therapy with small-molecule drugs. Some OMV-based vaccines are already on the market and have demonstrated good therapeutic effect on the corresponding diseases. OMV-based vaccines for cancer are also being studied, and some are already in clinical trials. This paper reviews bacterial outer membrane vesicles, their interaction with host cells, and their applications in tumor vaccines.

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“…The bacterial vector induces a robust immune response due to its natural components, including lipopolysaccharides (LPSs), peptidoglycan, and flagellin, which are recognized by the immune system [187]. Bacteria have specific features called pathogen-associated molecular patterns (PAMPs), recognized by Toll and Nod-like receptors [188]. This introduction induces the native immune response and enhances the adaptive immune response [136].…”

Section: Archaea Bacteria and Their By-productsmentioning

confidence: 99%

“…In addition to these, bacterial derivatives can be used as potentially useful nanocarriers for antigen delivery, some as "bacterial ghosts" that possess the ability to stimulate immune responses as potent as those of live bacteria [190]. Other components such as S-layer, endospores, and outer membrane vesicles (OMVs) are also applied, but the latter contains LPS which can cause immune toxicity [188].…”

Section: Archaea Bacteria and Their By-productsmentioning

confidence: 99%

Enhancing the Effect of Nucleic Acid Vaccines in the Treatment of HPV-Related Cancers: An Overview of Delivery Systems

et al. 2022

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Prophylactic vaccines against human papillomavirus (HPV) have proven efficacy in those who have not been infected by the virus. However, they do not benefit patients with established tumors. Therefore, the development of therapeutic options for HPV-related malignancies is critical. Third-generation vaccines based on nucleic acids are fast and simple approaches to eliciting adaptive immune responses. However, techniques to boost immunogenicity, reduce degradation, and facilitate their capture by immune cells are frequently required. One option to overcome this constraint is to employ delivery systems that allow selective antigen absorption and help modulate the immune response. This review aimed to discuss the influence of these different systems on the response generated by nucleic acid vaccines. The results indicate that delivery systems based on lipids, polymers, and microorganisms such as yeasts can be used to ensure the stability and transport of nucleic acid vaccines to their respective protein synthesis compartments. Thus, in view of the limitations of nucleic acid-based vaccines, it is important to consider the type of delivery system to be used—due to its impact on the immune response and desired final effect.

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Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Cited by 47 publications

References 334 publications

Engineered bacteria for augmentedin situtumor vaccination

Engineered bacteria for augmentedin situtumor vaccination

Bacterial outer membrane vesicles as a candidate tumor vaccine platform

Enhancing the Effect of Nucleic Acid Vaccines in the Treatment of HPV-Related Cancers: An Overview of Delivery Systems

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