Enfermedad tiroidea autoinmunitaria materna: repercusión en el recién nacido

Effects of Isolated Positive Maternal Thyroglobulin Antibodies on Brain Development of Offspring in an Experimental Autoimmune Thyroiditis Model

“…TgAb, which belongs to the immunoglobulin IgG subtype, can cross the placental barrier (12). However, exogenous antibody levels will decrease gradually in offspring (13). This is confirmed, for example, by an epidemiological study from Korea (14).…”

Ascertaining Newborn Nursery Provider Practices Regarding Thyroid Function Testing in Healthy Term Newborns

“… 9 - 13 Other recent studies have demonstrated utility in additional testing in the newborn period, although optimal timing of testing has not been determined. 1 , 3 , 6 , 8 , 14 Additional testing obtained unnecessarily has a significant impact on resource allocation and referrals; moreover, TFTs obtained too early after birth may be affected by the newborn’s physiologic thyroid-stimulating hormone surge and therefore yield false positive results. 8 , 14 This topic is controversial, as some amount of additional testing may be considered acceptable to ensure a diagnosis with preventable developmental implications is not missed.…”

“…In addition to congenital causes of hypothyroidism, maternal autoimmune thyroid disease can lead to transfer of thyrotropin receptor antibodies across the placenta and may cause a transient hyperthyrotropinemia or hypothyroidism in the infant or more rarely neonatal thyrotoxicosis. 1 - 7 The newborn screen is designed to detect congenital hypothyroidism, but testing modality varies state by state. In New York State, a 2-tiered screen with primary free thyroxine and a reflex thyroid-stimulating hormone is used.…”

“…There are currently no guidelines for obtaining additional testing in infants with maternal hypothyroidism apart from the newborn screen, and current literature has yielded mixed results on the topic. 1 , 3 , 8 - 14 Therefore, the question of whether additional screening apart from the newborn screen is warranted in these cases and the optimal timing to do so is controversial.…”

Knowledge regarding teratogens among women of childbearing age at a large tertiary care center in Saudi Arabia

“…Some of the comorbidities that pose a teratogenic risk include gestational diabetes mellitus which is associated with higher risk of congenital malformation,[ 6 7 8 ] thyroid related diseases and medications[ 9 10 ] and epilepsy medications. [ 11 12 13 ] Awareness of women showed insufficient knowledge regarding the teratogenicity of gestational diabetes mellitus,[ 14 ] thyroid diseases and medications[ 15 ] and epileptic medications.…”