Effects of Isolated Positive Maternal Thyroglobulin Antibodies on Brain Development of Offspring in an Experimental Autoimmune Thyroiditis Model

Wang, Xinyi; Liu, Haixia; Zhang, Yuanyuan; Li, Jiashu; Teng, Xiaochun; Liu, Aihua; Yu, Xiao‐Juan; Shan, Zhongyan; Teng, Weiping

doi:10.1089/thy.2014.0310

Cited by 18 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although interesting in light of the iodine fortification program, it is uncertain whether the higher prevalence of pregnant women with low, but positive, levels of TgAbs could have a pregnancy-related clinical significance (25,40). In the thorough meta-analysis by He et al (16), the studies defining antibody positivity at the highest titres did display a higher relative risk of preterm birth in antibodypositive women.…”

Section: Discussionmentioning

confidence: 99%

Increase in thyroglobulin antibody and thyroid peroxidase antibody levels, but not preterm birth-rate, in pregnant Danish women upon iodine fortification

Bliddal¹,

Boas

Hilsted

et al. 2017

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Increase in thyroglobulin antibody and thyroid peroxidase antibody levels, but not preterm birth-rate, in pregnant Danish women upon iodine fortification

Bliddal¹,

Boas

Hilsted

et al. 2017

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Morris water maze (MWM) assessment. Following treatment with naringin (100 and 200 mg/kg) for 16 weeks, MWM assessments were performed, as previously described (26,27). Rats from each group (4/group) were trained to swim freely with a circular Plexiglas platform (14 cm diameter) submerged 1.5 cm beneath the surface of the water prior to performing the MWM test.…”

Section: Animalsmentioning

confidence: 99%

Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model

Liang

et al. 2015

Molecular Medicine Reports

View full text Add to dashboard Cite

Naringenin is a flavonoid polyphenolic compound, which facilitates the removal of free radicals, oxidative stress and inflammation. The present study aimed to obtain a better understanding of the effects of curcumin on the regulation of diabetes‑associated cognitive decline, and its underlying mechanisms. An experimental diabetes mellitus (DM) rat model was induced by streptozoticin (50 mg/kg). Following treatment with naringin (100 and 200 mg/kg) for 16 weeks, the body weight and blood glucose levels of the DM rats were measured. A morris water maze test was used to analyze the effects of naringin on the cognitive deficit of the DM rats. The levels of oxidative stress, proinflammatory factors, caspase‑3 and caspase‑9, and the protein expression of peroxisome proliferator‑activated receptor γ (PPARγ) were quantified in the DM rats using a commercially‑available kit and western blot assay, respectively. In addition, a GW9662 PPARγ inhibitor (0.3 mg/kg) was administered to the DM rats to determine whether PPARγ affected the effects of naringin on the cognitive deficit of the DM rats. The results demonstrated that naringin increased the body weight, blood glucose levels, and cognitive deficits of the DM rats. The levels of oxidative stress and proinflammatory factors in the naringin‑treated rats were significantly lower, compared with those of the DM rats. In addition, naringin activated the protein expression of PPARγ, and administration of the PPARγ inhibitor decreased the protein expression of PPARγ, and attenuated the effects of naringin on cognitive deficit. The results also demonstrated that naringin decreased the expression levels of caspase‑3 and caspase‑9 in the DM rats. These results suggested that naringin ameliorated cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in the type 2 diabetic rat model. Furthermore, oxidative stress, proinflammatory factors and PPARγ signaling may be involved in mediating these effects.

show abstract

“…Matrix metalloproteinases (MMPs) are a family of metalloprotein endonucleases dependent on Zn ++ , which are involved in fibrosis, arthritis, tumor growth, migration, invasion and metastasis in pathological conditions (6)(7)(8). MMP, particularly MMP-9, is an important factor involved in acute spinal cord injury (9).…”

Section: Introductionmentioning

confidence: 99%

Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation

Zhang

2015

Molecular Medicine Reports

View full text Add to dashboard Cite

Rutin has extensive pharmacological activities, including antibacterial and anti-inflammatory activities, cooling of the blood to inhibit bleeding, reducing capillary wall fragility and anti-influenza activities. However, whether rutin can ameliorate neuropathic function in spinal cord injury (SCI) in constriction-induced peripheral nerve injury remains to be elucidated. In the present study, the potential protective effects of rutin on SCI rats were investigated. Neurological function was examined using the Basso, Beattie and Bresnahan (BBB) scoring system and by measuring the water content of the spinal cord tissue in SCI rats. SCI-induced programmed cell death was measured using hematoxylin and eosin staining. In addition, the expression of macrophage inflammatory protein-2 (MIP-2) and the activation of matrix metalloproteinase-9 (MMP-9) in the SCI rats were evaluated using ELISA assay kits and zymographic analysis, respectively. The phosphorylation of protein kinase B (p-Akt) was analyzed using a western blot assay. The results demonstrated that administrating rutin began to increase BBB scores and attenuate the spinal cord water content of the SCI rats. Administrating rutin prevented SCI-induced programmed cell death. The SCI rats of in the rutin-treated group were found to exhibit lower expression levels of MIP-2 and p-Akt, reduced MMP-9 activation, compared with the SCI model rats. In conclusion, rutin was demonstrated as a potential protective agent in SCI and enhances the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt.

show abstract

Effects of Isolated Positive Maternal Thyroglobulin Antibodies on Brain Development of Offspring in an Experimental Autoimmune Thyroiditis Model

Abstract: Isolated positive maternal TgAb did not clearly influence the learning ability and memory of offspring, or nerve cell migration, despite a transient increase in TgAb in immunized mice.

Cited by 18 publications

References 29 publications

Increase in thyroglobulin antibody and thyroid peroxidase antibody levels, but not preterm birth-rate, in pregnant Danish women upon iodine fortification

Increase in thyroglobulin antibody and thyroid peroxidase antibody levels, but not preterm birth-rate, in pregnant Danish women upon iodine fortification

Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model

Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation

Contact Info

Product

Resources

About