Energy, quiescence and the cellular basis of animal life spans

Stuart, Jeffrey A.; Brown, Melanie F.

doi:10.1016/j.cbpa.2005.11.002

Cited by 38 publications

(30 citation statements)

References 156 publications

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“…Studies on ectothermic species also found that while extending the lifespan of fruit flies and nematodes, DR does not lower metabolic rate after body mass is corrected (Houthoofd et al, 2002;Hulbert et al, 2004;Mair et al, 2003;Partridge et al, 2005;Walker et al, 2005). These findings indicate that lowering metabolic rate, including torpor and quiescence, is not crucial for DR to extend lifespan (Stuart and Brown, 2006), and they have been considered the major challenges of the RLT and OST (e.g., Brys et al, 2007;Speakman et al, 2004;Stuart and Brown, 2006).…”

Section: Explanation Of Controversial Empirical Results With the Concmentioning

confidence: 89%

“…The controversial correlation between energy, metabolic rate, and longevity has been considered a long-standing question (Balaban et al, 2005;Brys et al, 2007;Hughes and Reynolds, 2005;McCarter et al, 1985;Pérez et al, 2009;Speakman et al, 2004;Stuart and Brown, 2006). Here we suggest that in considering this question the detailed energy tradeoffs between life history traits and the efficiency of energy utilization have been largely ignored, which, we hypothesize, are the keys to understanding the complex nature of the energy longevity correlation.…”

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model

Hou

Amunugama

2015

Mechanisms of Ageing and Development

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The relationship between energy expenditure and longevity has been a central theme in aging studies. Empirical studies have yielded controversial results, which cannot be reconciled by existing theories. In this paper, we present a simple theoretical model based on first principles of energy conservation and allometric scaling laws. The model takes into considerations the energy tradeoffs between life history traits and the efficiency of the energy utilization, and offers quantitative and qualitative explanations for a set of seemingly contradictory empirical results. We show that oxidative metabolism can affect cellular damage and longevity in different ways in animals with different life histories and under different experimental conditions. Qualitative data and the linearity between energy expenditure, cellular damage, and lifespan assumed in previous studies are not sufficient to understand the complexity of the relationships. Our model provides a theoretical framework for quantitative analyses and predictions. The model is supported by a variety of empirical studies, including studies on the cellular damage profile during ontogeny; the intra- and inter-specific correlations between body mass, metabolic rate, and lifespan; and the effects on lifespan of (1) diet restriction and genetic modification of growth hormone, (2) the cold and exercise stresses, and (3) manipulations of antioxidant.

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Section: Explanation Of Controversial Empirical Results With the Concmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 89%

On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model

Hou

Amunugama

2015

Mechanisms of Ageing and Development

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show abstract

“…In most animal species, high energy levels in their bodies reveal fast growth, adequate energy storage, effective reproduction strategies and viable descendants with characteristic short life spans; however, reduced energy levels in a biological system results in affected gene expression, low survival rates and reduced metabolic rates and, therefore, a need on the part of physiological mechanisms to slow the ageing rate until environmental conditions are enhanced and higher energy levels are again reached (Stuart & Brown, 2006). In their natural habitat, many invertebrate species must undergo endogenous physiological processes during their life cycle, such as molting, starvation, quiescence and metamorphosis, among others.…”

Section: Invertebrate Challenges and How Marine Species Spend Energymentioning

confidence: 99%

“…Often, metabolic rates have been inversely related to the life span of mammals. Moreover, when mitochondrial respiration has been inhibited by RNAi techniques, the life span extends in C. elegans (Lee et al, 2003), and long-lived mutants of this nematode concomitantly show decreased metabolic rates (Stuart & Brown, 2006). The process by which mitochondrial respiration affects or extends life span has been studied in several organisms, including yeasts, worms, flies and mice (Lee et al, 2010).…”

Section: Invertebrate Challenges and How Marine Species Spend Energymentioning

confidence: 99%

Invertebrates Mitochondrial Function and Energetic Challenges

Martínez‐Cruz¹,

Sánchez‐Paz²,

García‐Carreño³

et al. 2012

Bioenergetics

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“…4 Aerobic cells express ROS defense proteins whose task is to protect cellular macromolecules from damage. 5 When ROS generation increases or when ROS defense mechanisms are compromised, cells are said to be under oxidative stress. As originally proposed by Harman, there is now considerable evidence linking oxidative stress to premature aging, a shortened life span and the development of various types of cancers and neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%