Energy metabolism and nutritional status in hospitalized patients with lung cancer

Takemura, Yumi; Sasaki, Makoto; Gotō, Kenichi; Takaoka, Azusa; Ohi, Akiko; Kurihara, Mika; Nakanishi, Naoko; Nakano, Yasutaka; Hanaoka, Jun

doi:10.3164/jcbn.16-1

Cited by 13 publications

(15 citation statements)

References 45 publications

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“…Tacke et al [44] subjects mainly had heart failure of NYHA functional class II or III, and thus severity of heart failure was similar between their study and ours. REE in our patients with heart failure was similar to that in healthy Japanese individuals reported in previous studies [34,45,46], one of which was carried out by our group, and no increases in energy metabolism were confirmed. Also, there was no correlation between BNP level and mREE/BW; in other words, there was no correlation between severity of heart failure and energy metabolism.…”

Section: Discussion/conclusionsupporting

confidence: 90%

“…2c). However, our previous reports showed positive correlation between energy metabolism and inflammatory cytokines [34,53]. This may be attributed to relatively lower IL-6 levels in heart failure patients as compared with patients with lung cancer or inflammatory bowel disease.…”

Section: Discussion/conclusionmentioning

confidence: 77%

“…Indirect Calorimetry mREE (kcal/kg/day), respiratory quotient (RQ), carbohydrate oxidation, and fat oxidation were measured by computed opencircuit indirect calorimetry (AE-300S, Minato Medical Science Co., Osaka, Japan) [30][31][32][33][34]. Indirect calorimetry was performed in the hospital room after 8 h of fasting.…”

Section: Definitionsmentioning

confidence: 99%

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Energy Metabolism and Nutritional Status in Hospitalized Patients with Chronic Heart Failure

et al. 2020

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Introduction: Malnutrition is a factor that defines vital prognosis in chronic heart failure. Objective: This study investigated nutritional and metabolic disorders in patients with heart failure by examining the association of severity of heart failure with inflammatory cytokines, appetite-regulating hormones, and energy metabolism. Methods: Subjects were 50 patients with heart failure. On admission, nutritional status was assessed, and biochemical blood tests were performed, including for serum tumor necrosis factor-α, interleukin-6, ghrelin, and leptin levels. Resting energy expenditure (REE) was also measured by indirect calorimetry to examine its association with severity of heart failure and levels of inflammatory cytokines and appetite-regulating hormones. Results: There were significant associations between serum brain natriuretic peptide (BNP) level and nutrition indices, indicating that nutritional status was worse when heart failure was more severe. Inflammatory cytokine levels showed significant positive correlations with BNP level. Measured REE/bodyweight was not associated with severity of heart failure, but was negatively correlated with body fat percentage and leptin levels. Conclusions: Energy metabolism was not associated with serum BNP level among patients with heart failure with New York Heart Association functional class up to III. Body fat percentage and leptin levels may be a good predictor of energy metabolism in patients with heart failure.

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Section: Discussion/conclusionsupporting

confidence: 90%

Section: Discussion/conclusionmentioning

confidence: 77%

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Energy Metabolism and Nutritional Status in Hospitalized Patients with Chronic Heart Failure

et al. 2020

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“…2 ). ( 25 – 27 ) Sample size was calculated using significance level (α) of 0.05 and power (1 – β) of 0.80. In results, a sample of 52 was statistical power 0.991 (stress factor) and 0.982 (REE/BW), and it was considered good.…”

Section: Resultsmentioning

confidence: 99%

Energy metabolism during the perioperative period of gastric endoscopic submucosal dissection

Chinda

Shimoyama

Hayamizu

et al. 2017

J. Clin. Biochem. Nutr.

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The aim of this study was to investigate the change in the energy metabolism and invasiveness in the perioperative period of endoscopic submucosal dissection for early gastric cancer. Fifty-two consecutive patients were enrolled into the study between July 2013 and May 2014 and examined resting energy expenditure using an indirect calorimeter, body weight and basal energy expenditure using the Harris–Benedict equation before and after endoscopic submucosal dissection. Resting energy expenditure/body weight and resting energy expenditure/basal energy expenditure were 20.2 ± 3.0 kcal/kg/day and 0.96 ± 0.11 on the day of endoscopic submucosal dissection, whereas one day after the endoscopic submucosal dissection they were 21.7 ± 3.2 kcal/kg/day and 1.03 ± 0.14, showing significant increases (p<0.001, respectively). The stress factor on the postoperative day 1 was computed as 1.07. This increase was low in comparison to that experienced for surgery, suggesting that the degree of perioperative invasiveness in patients receiving endoscopic submucosal dissection is lower in comparison to that during surgery (The study of the resting energy metabolism and stress factor using an indirect calorimeter in the perioperative period of endoscopic operation: UMIN000027135).

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“…A previous study has shown that leptin levels were significantly lower in patients with lung cancer than in healthy control [19]. Leptin is produced in adipose tissue and it has an effect in inhibiting energy intake, so the decrease in secretion of leptin may represent a mechanism of compensatory when there is imbalance in energy [20]. In another study, there was a decrease in leptin level between the groups of patients with lung cancer compared to the healthy control, and the study showed that the decrease level of leptin in lung cancer patients with weight loss is due to decreased production of leptin in advanced stages of cancer due to low fat mass caused by the case of cachexia which is a condition of loss of appetite, weight loss and muscle atrophy [21].…”

Section: Resultsmentioning

confidence: 98%

Estimation of the Leptin Hormone and Some Biochemical Variables in Patients with Lung Cancer in Kirkuk Province

AL-Qarghuli¹,

Laylani²,

Khalil³

2019

KUJSS

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This study aimed to estimate the level of leptin hormone and some biochemical variables in patients with lung cancer. Twenty five patients with lung cancer and 24 healthy control were enrolled in this study. The results showed a significant decrease in the level of leptin in patients with lung cancer compared to healthy control. In group of patients with lung cancer who had BMI ( 20 -23 kg/m 2 ), ( 24-26 kg/m 2 ), ( more than 30 kg/m 2 ) the levels of leptin were (1.42 ± 0.54), (4.35 ± 2.19), (8.75 ± 1.2) ng/ml respectively, comparing with the healthy control (4.89 ± 1.29), (6.85 ± 1.49), (9.85 ± 2.62) ng/ml respectively. The results also showed that there was a significant increase in activity of ALT in patients group (30.8 ± 16.4) U/L compared to healthy control (22.8 ± 6.55), while there was no statistically significant differences in the activity of AST in patients group (25.4 ± 8.9) U/L compared to healthy control (27 ± 9.2). There were no statistically significant correlation between leptin level with ALT ( r = -0.104 ) and AST ( r = 0.092 ).

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Energy metabolism and nutritional status in hospitalized patients with lung cancer

Cited by 13 publications

References 45 publications

Energy Metabolism and Nutritional Status in Hospitalized Patients with Chronic Heart Failure

Energy Metabolism and Nutritional Status in Hospitalized Patients with Chronic Heart Failure

Energy metabolism during the perioperative period of gastric endoscopic submucosal dissection

Estimation of the Leptin Hormone and Some Biochemical Variables in Patients with Lung Cancer in Kirkuk Province

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