Energy expenditure, nutrition status, and body composition in children with cystic fibrosis

Marín, Verónica; Velandia, Sylvia; Hunter, B.; Gattás, Vivien; Fielbaum, Oscar; Herrera, Oscar R.; Díaz, Erik

doi:10.1016/j.nut.2003.10.010

Cited by 27 publications

(20 citation statements)

References 48 publications

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“…In a study from Chile, on the other hand, REE and body composition in children with CF with a stable clinical picture without chronic respiratory infection was comparable to that in healthy children [32]. This is consistent with the results of the present study, in which the least disturbance of growth and nutritional status during the course of the disease was found in uncolonized children.…”

Section: Discussionsupporting

confidence: 92%

Effect of Selected Factors Associated with the Clinical Course of the Disease on Nutritional Status in Children with Cystic Fibrosis

Umławska¹,

Krzyzanowska²,

Zielińska³

et al. 2014

Adv Clin Exp Med

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Background. Malnutrition and delayed growth are commonly seen in children with cystic fibrosis and are indicators of poor prognosis. Understanding the factors that affect growth and nutritional status may improve care, treatment and longevity. Objectives. To determine how nutritional status, as estimated using anthropometric measurements, in children with cystic fibrosis is affected by 1) the type of CFTR mutation, 2) colonization by Pseudomonas aeruginosa, and 3) age at diagnosis. The relationship between nutritional status and pulmonary function was also investigated. Material and Methods. Anthropometric data on height, weight, circumferences and skinfold thicknesses were extracted from the medical histories of 41 boys and 48 girls diagnosed with cystic fibrosis who were treated at the Institute of Mother and Child in Warsaw, Poland. Muscle and fat tissue area were calculated from these measurements. The values for children with CF were compared to the Polish national growth reference charts. Multivariate linear regression tested the effect of three factors on nutritional status: colonization with P. aeruginosa, age at diagnosis, and the type of CFTR mutation. Results. All values for children with CF were significantly lower than in the reference population. The results show that, in the children examined, nutritional status is more adversely affected than growth. Of the factors related to the clinical picture of the disease, only the presence of respiratory tract colonization by P. aeruginosa had an effect on physical development in the children examined. Neither the type of mutation present nor age at diagnosis had any significant effect. Conclusions. Chronic colonization by P. aeruginosa interfered with growth and markedly worsened nutritional status, and was also associated with reductions in both total and lean body mass. Early nutritional intervention can improve nutritional state and pulmonary function in children with CF (Adv Clin Exp Med 2014, 23, 5, 775-783).

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Section: Discussionsupporting

confidence: 92%

Effect of Selected Factors Associated with the Clinical Course of the Disease on Nutritional Status in Children with Cystic Fibrosis

Umławska¹,

Krzyzanowska²,

Zielińska³

et al. 2014

Adv Clin Exp Med

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“…5 of the 8 patients with CF needed dietary supplementation by formula diet drinks to achieve the recommended 125% of normal daily energy intake [13], and none of them was fed by a nutrition tube. After LTx, the nutrition of all 46 patients was monitored.…”

Section: Study Populationmentioning

confidence: 99%

Reversibility of cachexia after bilateral lung transplantation

Habedank

Ewert

Hetzer

et al. 2009

International Journal of Cardiology

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“…Growth retardation and undernutrition are often seen in patients with cystic fibrosis (CF) as a result of several factors including malabsorption [1,2], reduced energy intake [3], increased energy expenditure [4,5] and the inflammatory state secondary to chronic pulmonary infection [6]. Such events lead to loss of fat mass and fat-free mass (FFM).…”

Section: Introductionmentioning

confidence: 99%

The influence of body composition on respiratory muscle, lung function and diaphragm thickness in adults with cystic fibrosis

Enright

Chatham

Ionescu

et al. 2007

Journal of Cystic Fibrosis

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Energy expenditure, nutrition status, and body composition in children with cystic fibrosis

Cited by 27 publications

References 48 publications

Effect of Selected Factors Associated with the Clinical Course of the Disease on Nutritional Status in Children with Cystic Fibrosis

Effect of Selected Factors Associated with the Clinical Course of the Disease on Nutritional Status in Children with Cystic Fibrosis

Reversibility of cachexia after bilateral lung transplantation

The influence of body composition on respiratory muscle, lung function and diaphragm thickness in adults with cystic fibrosis

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