Energy Donor Effect on the Sensing Performance for a Series of FRET-Based Two-Photon Fluorescent Hg2+ Probes

Zhang, Yujin; Hu, Wei

doi:10.3390/ma10020108

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Motivated by the results above, we next investigate the probability of the probes as a two-photon fluorescent sensor for β-amyloid imaging. The macroscopic TPA cross-section (σ TPA ) that can be directly compared to the experiment is defined as [40] σ TPA = 4π 2 a 5 0 α 15c…”

Section: β-Amyloid-specific Tpa Propertiesmentioning

confidence: 99%

Sensing Performance Investigations on Two-Photon Fluorescent Probes for Detecting β-Amyloid in Alzheimer’s Disease

Zhang

Luan

et al. 2020

Sensors

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Alzheimer’s disease (AD) is one of the most common forms of senile disease. In recent years, the incidence of AD has been increasing significantly with the acceleration of the aging process of the global population. However, current clinical drugs can only alleviate the symptoms of AD patients without healing the disease fundamentally. Therefore, it is of great significance to develop an effective small molecule diagnostic reagent for the early diagnosis of AD. In this paper, we employ an integrated approach, including molecular docking simulation and quantum mechanics/molecular mechanics calculation, to investigate the sensing performance of a series of donor–acceptor structural probes for the marker protein of AD (β-amyloid). Results show that the probes display evident fluorescence enhancement when bound to the β-amyloid, suggesting the effect of the environment on the molecular properties. Especially, the two-photon absorption cross-section of the probes increase drastically in the β-amyloid compared to that in vacuum, which results from the larger electron delocalization and dipole moment in the fibrillary-like environment. Thus, one can propose that the studied probes are capable of application in two-photon fluorescent imaging, particularly those containing naphthalene rings as the donor or with a longer spacer group. Our calculations elucidate the experimental measurements reasonably, and further establish possible structure–property relationships that can be used to design novel biocompatible two-photon fluorescent probes for the diagnosis of Alzheimer’s.

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Section: β-Amyloid-specific Tpa Propertiesmentioning

confidence: 99%

Sensing Performance Investigations on Two-Photon Fluorescent Probes for Detecting β-Amyloid in Alzheimer’s Disease

Zhang

Luan

et al. 2020

Sensors

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“…In the past decades, developing applicable methods to monitor NO in living cells has become an attractive subject [ 11 ]. Among various approaches that have been employed to detect NO, fluorescent imaging technique is regarded as one of the most promising one in view of its simplicity, high sensitivity, and real-time detection [ 12 , 13 , 14 , 15 , 16 ]. Thus, the design and synthesis of fluorescent probes for NO has drawn great attention.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Design of a Two-Photon Fluorescent Probe for Nitric Oxide with Enhanced Emission Induced by Photoninduced Electron Transfer

Zhang

Leng

2018

Sensors

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In the present work, we systematically investigate the sensing abilities of two recently literature-reported two-photon fluorescent NO probes, i.e., the o-phenylenediamine derivative of Nile Red and the p-phenylenediamine derivative of coumarin. The recognition mechanisms of these probes are studied by using the molecular orbital classifying method, which demonstrates the photoinduced electron transfer process. In addition, we have designed two new probes by swapping receptor units present on fluorophores, i.e., the p-phenylenediamine derivative of Nile Red and the o-phenylenediamine derivative of coumarin. However, it illustrates that only the latter has ability to function as off-on typed fluorescent probe for NO. More importantly, calculations on the two-photon absorption properties of the probes demonstrate that both receptor derivatives of coumarin possess larger TPA cross-sections than Nile Red derivatives, which makes a better two photon fluorescent probe. Our theoretical investigations reveal that the underlying mechanism satisfactorily explain the experimental results, providing a theoretical basis on the structure-property relationships which is beneficial to developing new two-photon fluorescent probes for NO.

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Performance‐Enhancing Selector via Symmetrical Multilayer Design

Sun

Zhao

Song

et al. 2019

Adv Funct Materials

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Two-terminal selectors with high nonlinearity, based on bidirectional threshold switching (TS) behaviors, are considered as a crucial element of crossbar integration for emerging nonvolatile memory and neuromorphic network. Although great efforts have been made to obtain various selectors, existing selectors cannot fully satisfy the rigorous standard of assorted memristive elements and it is in great demand to enhance the performance. Here, a new type of Ag/TaO x /TaO y /TaO x /Ag (x < y) selector based on homogeneous trilayered oxides is developed to attain the required parameters including bidirectional TS operation, a large selectivity of ≈10 10 , a high compliance current up to 1 mA, and ultralow switching voltages under 0.2 V. Tunable operation voltages can be realized by modulating the thickness of inserted TaO y . All-TaO x -based integrated 1S1R (one selector and one memristor) cells, prepared completely by magnetron sputtering and no need of a middle electrode, exhibit a nonlinear feature, which is quite characteristic for the crossbar devices, avoiding undesired crosstalk current issues. The tantalum-oxidebased homojunctions offer high insulation, low ion mobility, and rich interfaces, which is responsible for the modulation of Ag conductive filaments and corresponding high-performance cation-based selector. These findings might advance practical implementation of two-terminal selectors in emerging memories, especially resistive random access memories.tile memory and neuromorphic computing applications. [1] These applications are generally based on the crossbar array structure, where crosstalk current issues notoriously impede the read-write operations. [2] A great deal of efforts have been made to address the critical issue, and the two-terminal selector stands out for their simple structure and no need to compromise the scalability from numerous solutions. [3] Figure 1a illustrates the configuration of 1S1R (one selector and one memristor) integrated crossbar arrays. Recently, various selector elements have been introduced, including Schottky diodes, [4] metal-insulator transition, [5] fieldassisted superlinear threshold, [6] mixedionic-electronic conduction, [7] thermionic/ tunneling emission, [8] and electrochemical-metallization-based (ECM) threshold switching (TS). [9] One Schottky diode cascaded with one memristor (namely, 1D1R) is confined only to unipolar RRAM due to the unilateral conductivity of diodes. Selectors based on transport of ions and electrons are applicable to both unipolar and bipolar RRAM, but the gradually varied voltage-current (I-V) curves predestinates the moderate nonlinearity, [3b] which is not sufficient for the application of RRAM crossbar arrays.The ECM-based selector, which is based on the formation/ diffusion and Rayleigh instability of conductive filaments Nonvolatile MemoryThe ORCID identification number(s) for the author(s) of this article can be found under https://doi.

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Energy Donor Effect on the Sensing Performance for a Series of FRET-Based Two-Photon Fluorescent Hg2+ Probes

Cited by 6 publications

References 34 publications

Sensing Performance Investigations on Two-Photon Fluorescent Probes for Detecting β-Amyloid in Alzheimer’s Disease

Sensing Performance Investigations on Two-Photon Fluorescent Probes for Detecting β-Amyloid in Alzheimer’s Disease

Theoretical Design of a Two-Photon Fluorescent Probe for Nitric Oxide with Enhanced Emission Induced by Photoninduced Electron Transfer

Performance‐Enhancing Selector via Symmetrical Multilayer Design

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