With ecological problems and energy crises intensifying today, greening is essential to sustainable development. Compared with other types of buildings, hospital buildings account for a relatively larger proportion of building energy consumption. In order to realize the rapid cycle optimization of a green hospital project in the design stage and improve the green grade of the building, a pre-evaluation Building Information Model (BIM) of green hospital building performance was established in this study. Firstly, the literature review and expert consultation established the building performance pre-evaluation index system for green hospitals. Then, BIM technology is taken to extract data needed for building a performance pre-evaluation system, and the Cloud Model and the Matter–Element Extension Theory are used to build models. The final green grade calculation is realized in MATLAB. Finally, the Maluan Bay Hospital is taken as an example to test the applicability and effectiveness of the proposed model. The results show that the green hospital building performance pre-evaluation model has advantages of simulation, cyclic optimization and fuzzy quantification, which can effectively guide the design and construction of a green hospital.